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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.12
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca)
cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)
Anatomy Link Frequency
stroma 1
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
Migraine 24 90.92 High High
Dopamine 159 89.60 High High
Calcium channel 3 83.04 Quite High
Dismenorea 4 79.00 Quite High
Potency 2 62.16 Quite High
long-term potentiation 8 59.04 Quite High
midbrain 9 32.96 Quite Low
Glutamate 31 5.00 Very Low Very Low Very Low
Substantia nigra 19 5.00 Very Low Very Low Very Low
Catecholamine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 13 90.92 High High
Migraine With Aura 10 89.36 High High
Ataxia 1 81.56 Quite High
Dysmenorrhea 4 79.00 Quite High
Epilepsy 18 75.16 Quite High
Congenital Anomalies 5 65.04 Quite High
Aging 6 64.04 Quite High
Parkinson's Disease 36 37.76 Quite Low
Apoptosis 6 25.24 Quite Low
Migraine Without Aura 2 24.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings are supported by our in vivo studies (Figs. 3 and 6), suggesting the possibility that (i) TH inhibition may be caused by an up-regulation of PP2A activity that is triggered by a-Syn overexpression, (ii) PP2A activation and TH inhibition may be independently triggered by a-Syn overexpression leading to interactions that affect both enzymes, or (iii) that TH inhibition may be an additive consequence of a-Syn overexpression and its ability to activate PP2A.
Localization (activation) of PP2A
1) Confidence 0.66 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.06 Pain Relevance 0.04
In experiments utilizing a phosphopeptide substrate (pT), PP2A efficiently cleaved phosphate from pT (362 ± 108 pmol/min/?
Localization (cleaved) of PP2A
2) Confidence 0.66 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.03
Conversely, PP2A was localized to the endometrial stroma.
Localization (localized) of PP2A in stroma
3) Confidence 0.66 Published 2000 Journal Biol. Reprod. Section Abstract Doc Link 10952921 Disease Relevance 0.22 Pain Relevance 0.22
The total concentration of PKA, PP2A, PP2B, and cdk5 were set to 10% of control values, and the dynamics of the PKA system were accelerated, i.e., the rate constants for all reactions involving PKA were increased 100-fold.
Localization (concentration) of PP2A
4) Confidence 0.48 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.10
This is unlikely for the alpha-2 subunit of the Na-K ATPase, of which the gene ATP1A2 is mutated in FHM2 [24], because the alpha-2 isoform is found at intracellular membranes [25] and not at the NMJ, where the major role is played by the alpha-3 isoform [26].
Neg (not) Localization (found) of alpha-2 isoform in NMJ
5) Confidence 0.05 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245992 Disease Relevance 0.83 Pain Relevance 0.54

General Comments

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