INT90289

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Context Info
Confidence 0.17
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 8.07
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gpx1) mitochondrion (Gpx1) oxidoreductase activity (Gpx1)
nucleus (Gpx1) lipid metabolic process (Gpx1) cytoplasm (Gpx1)
Anatomy Link Frequency
liver 8
blood 2
Gpx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Visceral pain 28 100.00 Very High Very High Very High
Pain score 4 90.28 High High
anesthesia 7 88.52 High High
Inflammation 36 79.76 Quite High
cytokine 30 78.72 Quite High
ischemia 18 56.88 Quite High
metalloproteinase 10 29.92 Quite Low
Pain 12 25.00 Low Low
Inflammatory response 10 11.28 Low Low
medulla 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

32 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

28 100.00 Very High Very High Very High
Stress 69 95.08 Very High Very High Very High
Thyroid Disease 27 93.60 High High
Pain 4 90.28 High High
Fracture Healing 128 89.32 High High
Disease 41 89.04 High High
Cognitive Disorder 40 86.00 High High
INFLAMMATION 47 79.76 Quite High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute estradiol injection caused a significant increase in both MDA levels and GPx activity in liver tissue when compared to the controls, (p <0.05 and p <0.02; respectively).
Positive_regulation (increase) of Gene_expression (levels) of GPx in liver
1) Confidence 0.17 Published 1999 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10954129 Disease Relevance 0 Pain Relevance 0.09
Following CRD we observed (1) all rats expressed signs of visceral pain (overall rating was 1.83), (2) SOD and GPx levels were increased in the liver and blood, and decreased in the brain samples and (3) administration of the antioxidant Trolox, a water-soluble derivate of vitamin E, prior to CRD, prevented SOD and GPx changes in the liver, blood and brain, but did not affect pain scores.
Positive_regulation (increased) of Gene_expression (levels) of GPx in liver associated with visceral pain and pain score
2) Confidence 0.11 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417688 Disease Relevance 0.33 Pain Relevance 0.65
Following CRD we observed (1) all rats expressed signs of visceral pain (overall rating was 1.83), (2) SOD and GPx levels were increased in the liver and blood, and decreased in the brain samples and (3) administration of the antioxidant Trolox, a water-soluble derivate of vitamin E, prior to CRD, prevented SOD and GPx changes in the liver, blood and brain, but did not affect pain scores.
Positive_regulation (Following) of Gene_expression (levels) of GPx in liver associated with visceral pain and pain score
3) Confidence 0.11 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417688 Disease Relevance 0.33 Pain Relevance 0.66
Although none of the four GPX genes we tested in RT-PCR were individually statistically significantly overexpressed in the EST analysis, there were no ESTs for any of these GPX genes in normal bone and a total of 85 ESTs for the four GPX genes in the PF7 and PF10 EST libraries.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of GPX
4) Confidence 0.09 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.26 Pain Relevance 0
Although none of the four GPX genes we tested in RT-PCR were individually statistically significantly overexpressed in the EST analysis, there were no ESTs for any of these GPX genes in normal bone and a total of 85 ESTs for the four GPX genes in the PF7 and PF10 EST libraries.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of GPX
5) Confidence 0.08 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.27 Pain Relevance 0
However, our data with resveratrol demonstrated an increase in the levels of GSH, GPx, and SOD levels suggesting that resveratrol in our system is also exhibiting antioxidant signaling properties similar to that observed by Kode et al. [39]
Positive_regulation (increase) of Gene_expression (levels) of GPx
6) Confidence 0.06 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0.31 Pain Relevance 0.16
It has been found that the elevated expression of antioxidant enzymes including CAT, SOD, glutathione peroxidase (GPx) [10-15], and more recently heme oxygenase-1 [16,17], prior to renal oxidant insult, was able to ameliorate renal damage.
Positive_regulation (elevated) of Gene_expression (expression) of GPx
7) Confidence 0.06 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1291371 Disease Relevance 0.43 Pain Relevance 0.03
However, our data with resveratrol demonstrated an increase in the levels of GSH, GPx, and SOD levels suggesting that resveratrol in our system is also exhibiting antioxidant signaling properties similar to that observed by Kode et al. [39]
Positive_regulation (increase) of Gene_expression (levels) of GPx
8) Confidence 0.05 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0.31 Pain Relevance 0.16
Depleted levels of GPx were restored by treatment with both deferoxamine and resveratrol in the MCP230 treated cells, whereas GPx was restored only by resveratrol treatment in the CuO/silica treated cells.


Positive_regulation (restored) of Gene_expression (levels) of GPx
9) Confidence 0.04 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0.07 Pain Relevance 0
Decreases in the levels or activities of anti-oxidant enzymes, such as SOD and GPx, and of both water soluble and lipophilic antioxidant micronutrients such as vitamins A, C and E, and ?
Positive_regulation (as) of Gene_expression (levels) of GPx
10) Confidence 0.04 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1420275 Disease Relevance 0.68 Pain Relevance 0
Following CRD we observed (1) all rats expressed signs of visceral pain (overall rating was 1.83), (2) SOD and GPx levels were increased in the liver and blood, and decreased in the brain samples and (3) administration of the antioxidant Trolox, a water-soluble derivate of vitamin E, prior to CRD, prevented SOD and GPx changes in the liver, blood and brain, but did not affect pain scores.
Positive_regulation (increased) of in blood Gene_expression (levels) of GPx in liver associated with visceral pain and pain score
11) Confidence 0.04 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417688 Disease Relevance 0.33 Pain Relevance 0.65
Following CRD we observed (1) all rats expressed signs of visceral pain (overall rating was 1.83), (2) SOD and GPx levels were increased in the liver and blood, and decreased in the brain samples and (3) administration of the antioxidant Trolox, a water-soluble derivate of vitamin E, prior to CRD, prevented SOD and GPx changes in the liver, blood and brain, but did not affect pain scores.
Positive_regulation (Following) of in blood Gene_expression (levels) of GPx in liver associated with visceral pain and pain score
12) Confidence 0.04 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417688 Disease Relevance 0.33 Pain Relevance 0.66

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