INT90299

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.54
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1a) ATPase activity (Abcb1a) plasma membrane (Abcb1a)
transmembrane transport (Abcb1a)
Abcb1a (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 16 99.70 Very High Very High Very High
antinociception 3 99.64 Very High Very High Very High
Morphine 11 99.32 Very High Very High Very High
tolerance 6 99.08 Very High Very High Very High
agonist 3 96.80 Very High Very High Very High
Opioid 1 94.76 High High
Analgesic 4 94.20 High High
Cannabinoid receptor 2 86.64 High High
Antinociceptive 2 78.68 Quite High
nMDA receptor antagonist 1 76.56 Quite High
Disease Link Frequency Relevance Heat
Leukemia 2 92.96 High High
Cancer 4 74.96 Quite High
Appetite Loss 2 61.88 Quite High
Vomiting 2 60.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was undertaken to assess morphine antinociception in mice lacking the mdr1a gene for expression of P-gp in the CNS.
Negative_regulation (lacking) of Gene_expression (expression) of mdr1a associated with antinociception and morphine
1) Confidence 0.43 Published 2000 Journal Pharm. Res. Section Abstract Doc Link 10955852 Disease Relevance 0 Pain Relevance 0.59
These results imply that oxymatrine prevention of the development of tolerance of morphine may be related to a considerable inhibition of P-gp expression.
Negative_regulation (inhibition) of Gene_expression (expression) of P-gp associated with tolerance and morphine
2) Confidence 0.18 Published 2010 Journal Integr Cancer Ther Section Abstract Doc Link 20587445 Disease Relevance 0 Pain Relevance 1.31
However, in CEM/VLB(100) cells, prolonged 72 h exposure to the cannabinoids, THC and CBD, decreased P-gp expression to a similar extent as the flavonoid, curcumin (turmeric).
Negative_regulation (decreased) of Gene_expression (expression) of P-gp associated with cannabinoid
3) Confidence 0.16 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16458258 Disease Relevance 0.36 Pain Relevance 0.44
Further, plant-derived cannabinoids are moderately effective in reversing MDR in CEM/VLB(100) cells by decreasing P-gp expression.
Negative_regulation (decreasing) of Gene_expression (expression) of P-gp associated with cannabinoid
4) Confidence 0.12 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16458258 Disease Relevance 0.18 Pain Relevance 0.30

General Comments

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