INT90300

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2011
Negated 3
Speculated 1
Reported most in Abstract
Documents 56
Total Number 58
Disease Relevance 11.05
Pain Relevance 22.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1a) ATPase activity (Abcb1a) plasma membrane (Abcb1a)
transmembrane transport (Abcb1a)
Anatomy Link Frequency
brain 7
liver 5
plasma 2
intestine 2
hippocampus 2
Abcb1a (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 104 100.00 Very High Very High Very High
Oxycodone 54 99.92 Very High Very High Very High
qutenza 25 99.92 Very High Very High Very High
induced neuropathy 4 99.80 Very High Very High Very High
Hippocampus 12 99.68 Very High Very High Very High
antinociception 9 99.64 Very High Very High Very High
Cannabinoid 16 99.50 Very High Very High Very High
vincristine 41 99.42 Very High Very High Very High
Bile 141 99.36 Very High Very High Very High
Paracetamol 9 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 6 99.80 Very High Very High Very High
Anxiety Disorder 4 99.64 Very High Very High Very High
Myeloid Leukemia 101 99.14 Very High Very High Very High
Gallstones 83 98.88 Very High Very High Very High
Intrahepatic Cholestasis 10 98.48 Very High Very High Very High
Disease 45 98.12 Very High Very High Very High
Colon Cancer 90 98.00 Very High Very High Very High
Drug Induced Neurotoxicity 17 97.44 Very High Very High Very High
Salivary Gland Disease 1 95.84 Very High Very High Very High
Cancer 466 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was undertaken to assess morphine antinociception in mice lacking the mdr1a gene for expression of P-gp in the CNS.
Gene_expression (expression) of mdr1a associated with antinociception and morphine
1) Confidence 0.78 Published 2000 Journal Pharm. Res. Section Abstract Doc Link 10955852 Disease Relevance 0 Pain Relevance 0.59
This study was undertaken to assess morphine antinociception in mice lacking the mdr1a gene for expression of P-gp in the CNS.
Gene_expression (expression) of P-gp associated with antinociception and morphine
2) Confidence 0.78 Published 2000 Journal Pharm. Res. Section Abstract Doc Link 10955852 Disease Relevance 0 Pain Relevance 0.58
These results suggest that differential expression of P-gp and possibly MRP1 contributes to the gestational-induced changes in brain and fetal uptake of saquinavir.
Gene_expression (expression) of P-gp in brain
3) Confidence 0.75 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19116954 Disease Relevance 0 Pain Relevance 0.46
Using a mouse model, the effects of gestational age on P-gp and MRP expression in the placenta and brain were evaluated.
Gene_expression (expression) of P-gp in brain
4) Confidence 0.75 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19116954 Disease Relevance 0 Pain Relevance 0.29
Potential P-gp inducers (rifampin and morphine) were administered subchorionically to P-gp-competent [mdr1a(+/+)] mice to induce P-gp expression in brain; the impact of rifampin pretreatment on brain penetration of verapamil also was evaluated with an in situ brain perfusion technique.
Gene_expression (expression) of P-gp in brain associated with morphine
5) Confidence 0.75 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721332 Disease Relevance 0 Pain Relevance 0.22
Dietary regulation of P-gp function and expression.
Gene_expression (expression) of P-gp
6) Confidence 0.73 Published 2009 Journal Expert Opin Drug Metab Toxicol Section Title Doc Link 19545213 Disease Relevance 0 Pain Relevance 0.15
Studies on piperine and capsaicin have underscored an often poor correlation between in vivo and in vitro data, whereas experiments involving curcumin highlighted differences between acute and chronic consumption of a dietary component on P-gp function and expression in vivo.
Gene_expression (expression) of P-gp associated with qutenza
7) Confidence 0.73 Published 2009 Journal Expert Opin Drug Metab Toxicol Section Abstract Doc Link 19545213 Disease Relevance 0 Pain Relevance 0.17
This study was undertaken to assess morphine antinociception in mice lacking the mdr1a gene for expression of P-gp in the CNS.
Neg (lacking) Gene_expression (lacking) of mdr1a associated with antinociception and morphine
8) Confidence 0.68 Published 2000 Journal Pharm. Res. Section Abstract Doc Link 10955852 Disease Relevance 0 Pain Relevance 0.59
The aim of the present study was to evaluate the chronicity and reversibility of the modulating effect of capsaicin on both the P-gp expression and activity in the Caco-2 cell monolayers.
Gene_expression (expression) of P-gp in Caco-2 associated with qutenza
9) Confidence 0.61 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.56
Effects of capsaicin on P-gp function and expression in Caco-2 cells.
Gene_expression (expression) of P-gp in Caco-2 associated with qutenza
10) Confidence 0.61 Published 2006 Journal Biochem. Pharmacol. Section Title Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.85
In addition, a multidrug resistance 3 gene mutation in exon 14 has been recently detected in a patient who developed cholelithiasis in adolescence, followed by cholestasis of pregnancy and finally adulthood biliary cirrhosis [31].
Gene_expression (detected) of multidrug resistance 3 associated with biliary liver cirrhosis and gallstones
11) Confidence 0.58 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 1.55 Pain Relevance 0.11
These mice completely lack phospholipids in their bile [67], but the bile PC is fully recovered with the overexpression of h-MDR3 [68].
Gene_expression (overexpression) of h-MDR3 in bile associated with bile
12) Confidence 0.52 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.26 Pain Relevance 0.14
The expression level of the h-MDR3 gene affects the development of hepatobiliary diseases [69].
Gene_expression (expression) of h-MDR3 associated with disease
13) Confidence 0.52 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.26 Pain Relevance 0.13
Mice with RIs of 60–80% were fed a standard laboratory chow containing 0.3% (wt/wt) BF for 7 days, and their livers were analyzed for MDR3 mRNA and protein expression [39].
Spec (analyzed) Gene_expression (expression) of MDR3 in livers
14) Confidence 0.51 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.20 Pain Relevance 0.08
P-glycoprotein (P-gp) and organic anion transporting polypeptides (Oatp) are expressed at the blood-brain barrier (BBB).
Gene_expression (expressed) of P-gp in brain
15) Confidence 0.51 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11257421 Disease Relevance 0 Pain Relevance 0.29
These findings display that oxycodone is a P-gp substrate, induces overexpression of P-gp, and affects paclitaxel's tissue distribution in a manner that may influence its chemotherapeutic activity.
Gene_expression (overexpression) of P-gp associated with oxycodone
16) Confidence 0.27 Published 2007 Journal J Pharm Sci Section Abstract Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.75
The objective of this study was to assess the P-gp affinity status of oxycodone, the P-gp expression, and the paclitaxel's tissue distribution in oxycodone-treated rats.
Gene_expression (expression) of P-gp associated with oxycodone
17) Confidence 0.27 Published 2007 Journal J Pharm Sci Section Abstract Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.58
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Gene_expression (expression) of MDR1a in intestine
18) Confidence 0.27 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.04
Using a mouse model, the effects of gestational age on P-gp and MRP expression in the placenta and brain were evaluated.
Gene_expression (expression) of P-gp in placenta
19) Confidence 0.26 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19116954 Disease Relevance 0 Pain Relevance 0.29
In contrast, the authors' data suggest that the mechanism of oxymatrine enhancement of morphine's analgesic effects is not associated with increase in the level of expression of P-gp.
Gene_expression (expression) of P-gp associated with analgesic and morphine
20) Confidence 0.24 Published 2010 Journal Integr Cancer Ther Section Abstract Doc Link 20587445 Disease Relevance 0 Pain Relevance 1.25

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