INT90313

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 57
Total Number 58
Disease Relevance 22.23
Pain Relevance 26.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
ventral 6
renal tubules 2
ventricles 2
brain 2
cleavage 2
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 145 100.00 Very High Very High Very High
Nucleus accumbens 47 100.00 Very High Very High Very High
cocaine 37 100.00 Very High Very High Very High
Nicotine 32 100.00 Very High Very High Very High
antagonist 59 99.98 Very High Very High Very High
Glutamate 733 99.82 Very High Very High Very High
ischemia 227 99.82 Very High Very High Very High
nMDA receptor 35 99.74 Very High Very High Very High
Ventral tegmentum 25 99.70 Very High Very High Very High
bDMF 6 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 902 100.00 Very High Very High Very High
Cv Unclassified Under Development 182 99.82 Very High Very High Very High
Spinal Cord Injury 204 99.36 Very High Very High Very High
Drug Dependence 6 99.00 Very High Very High Very High
Death 548 98.92 Very High Very High Very High
Cancer 87 98.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 97.24 Very High Very High Very High
Spondylosis 2 97.00 Very High Very High Very High
Injury 172 95.88 Very High Very High Very High
Retina Disease 17 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-apoptotic mechanisms induced by PC are several: induction of Bcl-2, reductions in caspase-3 synthesis and p-53 activation, and reductions in mitochondrial cytochrome c [9,185].


Negative_regulation (reductions) of Gene_expression (synthesis) of caspase-3 associated with apoptosis
1) Confidence 0.57 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.81 Pain Relevance 0.54
After conditioning, CPP expression and locomotion were determined simultaneously in the presence and absence of the respective reward (i.e. food or drug), or after application of 50 mg/kg MPEP (the dose that was most effective in reducing morphine CPP expression in our previous study).
Negative_regulation (reducing) of Gene_expression (expression) of CPP associated with morphine
2) Confidence 0.51 Published 2005 Journal Addict Biol Section Abstract Doc Link 16109585 Disease Relevance 0 Pain Relevance 0.29
Furthermore, only expression of amphetamine CPP was inhibited by MPEP, while expression of food and MDMA CPP was not affected, suggesting that the MPEP-induced inhibition of amphetamine CPP expression was not causally linked to the reduction of locomotion.
Negative_regulation (inhibition) of Gene_expression (expression) of CPP
3) Confidence 0.51 Published 2005 Journal Addict Biol Section Abstract Doc Link 16109585 Disease Relevance 0 Pain Relevance 0.25
The evaluation of the anti-craving-drug effects revealed that neither acamprosate and naloxone given separately nor their combined administration significantly reduced cocaine- or morphine-CPP expression.
Negative_regulation (reduced) of Gene_expression (expression) of CPP associated with narcan, morphine and cocaine
4) Confidence 0.51 Published 2005 Journal Amino Acids Section Abstract Doc Link 15791393 Disease Relevance 0 Pain Relevance 0.62
However, pre-testing injections of diazepam blocked the expression of amphetamine-induced CPP, and co-injections of diazepam blocked the formation of amphetamine CPP.
Negative_regulation (blocked) of Gene_expression (expression) of CPP
5) Confidence 0.51 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10958076 Disease Relevance 0 Pain Relevance 0
A reduction of the expression of morphine-induced CPP was observed on intra-ventral tegmental area injection of GABA(A) receptor antagonist bicuculline (25 microg/rat).
Negative_regulation (reduction) of Gene_expression (expression) of CPP in ventral associated with ventral tegmentum, gaba, antagonist and morphine
6) Confidence 0.51 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.56
Intra-ventral tegmental area administration of the GABA(A) receptor agonist, muscimol (6 microg/rat) reduced the expression of morphine-induced CPP.
Negative_regulation (reduced) of Gene_expression (expression) of CPP in ventral associated with ventral tegmentum, gaba, agonist and morphine
7) Confidence 0.51 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.41
Baclofen (12 microg/rat) increased where as (19 and 25 microg/rat) reduced the expression of morphine-induced CPP.
Negative_regulation (reduced) of Gene_expression (expression) of CPP associated with morphine
8) Confidence 0.51 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.57
On the day following acquisition of morphine CPP, a single administration of SPD at 10 or 20 mg/kg failed to block the expression of CPP.
Negative_regulation (block) of Gene_expression (expression) of CPP associated with morphine
9) Confidence 0.50 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17027045 Disease Relevance 0 Pain Relevance 1.05
The expression of CPP could be significantly inhibited by multiple treatments with EA of either 2 Hz or 100 Hz.


Negative_regulation (inhibited) of Gene_expression (expression) of CPP
10) Confidence 0.43 Published 2003 Journal Beijing Da Xue Xue Bao Section Body Doc Link 12914238 Disease Relevance 0 Pain Relevance 0
The expression of morphine-induced CPP was significantly blocked by mirtazapine (10 or 30 mg/kg, i.p.), while chronic treatment with mirtazapine (1 or 10 mg/kg, i.p. once, daily, for six consecutive days) significantly attenuated the acquisition of morphine CPP.
Negative_regulation (blocked) of Gene_expression (expression) of CPP associated with morphine
11) Confidence 0.43 Published 2008 Journal Am J Drug Alcohol Abuse Section Abstract Doc Link 18618337 Disease Relevance 0.07 Pain Relevance 1.07
Injection of CGP38345 (10, 19, 25 and 50 microg/rat) into the ventral tegmental area significantly reduced the expression of CPP induced by morphine.
Negative_regulation (reduced) of Gene_expression (expression) of CPP in ventral associated with ventral tegmentum and morphine
12) Confidence 0.43 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.53
AIM: To determine the expression of c-Fos, caspase-3 and interleukin-1beta (IL-1beta) in the cervical cord and stomach of rats with cervical spondylosis, to analyze their relationship, and to offer an explanation of one possible cause for functional dyspepsia (FD) and irritable bowel syndrome (IBS) caused by cervical spondylosis.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of caspase-3 in stomach associated with spondylosis, spastic colon and nud
13) Confidence 0.43 Published 2007 Journal World J. Gastroenterol. Section Abstract Doc Link 17552004 Disease Relevance 0.45 Pain Relevance 0.14
Methodologically, the repeated-testing-schedule produced stable CPP expression in both groups over 12 subsequent tests.
Negative_regulation (produced) of Gene_expression (expression) of CPP
14) Confidence 0.43 Published 2005 Journal Amino Acids Section Abstract Doc Link 15791393 Disease Relevance 0 Pain Relevance 0.58
Light-emitting diode pretreatment significantly decreased the expression of caspase-3 elicited by potassium cyanide.
Negative_regulation (decreased) of Gene_expression (expression) of caspase-3
15) Confidence 0.42 Published 2006 Journal Neuroscience Section Abstract Doc Link 16464535 Disease Relevance 0.82 Pain Relevance 0.06
ALCAR reduces cytosolic cytochrome C and caspase 3 active fragments expression in a significant manner with respect to saline treatment.
Negative_regulation (reduces) of Gene_expression (expression) of caspase 3
16) Confidence 0.41 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17714181 Disease Relevance 1.46 Pain Relevance 0.56
Simvastatin improves tissue structure and reduces the expression of caspase-3 in kidney from SCI rats
Negative_regulation (reduces) of Gene_expression (expression) of caspase-3 in kidney associated with spinal cord injury
17) Confidence 0.39 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873501 Disease Relevance 0.24 Pain Relevance 0
Furthermore, only expression of amphetamine CPP was inhibited by MPEP, while expression of food and MDMA CPP was not affected, suggesting that the MPEP-induced inhibition of amphetamine CPP expression was not causally linked to the reduction of locomotion.
Negative_regulation (inhibited) of Gene_expression (expression) of CPP
18) Confidence 0.38 Published 2005 Journal Addict Biol Section Abstract Doc Link 16109585 Disease Relevance 0 Pain Relevance 0.27
It was shown that both nicotinic receptor ligands attenuated the acquisition and expression of nicotine CPP as well as the expression of reinstatement of nicotine CPP provoked by both drugs.
Negative_regulation (attenuated) of Gene_expression (expression) of CPP associated with nicotine
19) Confidence 0.37 Published 2010 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 20217050 Disease Relevance 0.08 Pain Relevance 1.11
It was shown that both nicotinic receptor ligands attenuated the acquisition and expression of nicotine CPP as well as the expression of reinstatement of nicotine CPP provoked by both drugs.
Negative_regulation (attenuated) of Gene_expression (expression) of CPP associated with nicotine
20) Confidence 0.37 Published 2010 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 20217050 Disease Relevance 0.08 Pain Relevance 1.09

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