INT90315

Context Info Confidence 0.55 First Reported 2000 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 4 Total Number 5 Disease Relevance 2.00 Pain Relevance 1.83

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)

Anatomy Link Frequency respiratory 2 Nr3c2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat imagery 36 100.00 antidepressant 12 99.98 5HT 8 99.76 cerebral cortex 1 95.20 antagonist 4 92.24 noradrenaline 5 90.16 Serotonin 1 89.04 corticosteroid 19 87.88 monoamine 2 87.08 fluoxetine 3 85.60

Disease Link Frequency Relevance Heat Stress 108 99.08 Syndrome 4 95.60 Post-traumatic Stress Disorder 54 94.24 Anxiety Disorder 20 93.28 Attention Deficit Hyperactivity Disorder 3 79.24 Depression 5 68.40 Cognitive Disorder 2 68.36 Injury 11 65.20 INFLAMMATION 11 53.56 Vasculitis 9 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MR mRNA expression was induced in hippocampal CA1/CA2 subregions (27-37%) by all antidepressants, while moclobemide and 8-OH-DPAT significantly increased GR gene expression mainly in the CA1 region (31-44%).

Positive_regulation (induced) of Gene_expression (expression) of MR mRNA associated with antidepressant

1) Confidence 0.55 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.32

It is not known whether homodimers, heterodimers, or both caused the decreased expression of MR and GR.

Spec (whether) Positive_regulation (caused) of Gene_expression (expression) of MR

2) Confidence 0.45 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.50 Pain Relevance 0.11

Antidepressants increase expression of hippocampal MR and decrease basal and stress-induced HPA activity.

Positive_regulation (increase) of Gene_expression (expression) of MR associated with stress and antidepressant

3) Confidence 0.39 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.12 Pain Relevance 0.18

Exposure of hippocampal cells to 5HT for 4 days increased both glucocorticoid and mineralocorticoid receptor mRNA and protein expression.

Positive_regulation (increased) of Gene_expression (expression) of mineralocorticoid receptor associated with 5ht

4) Confidence 0.03 Published 2003 Journal Neuroscience Section Abstract Doc Link 12732243 Disease Relevance 0.21 Pain Relevance 0.93

For MR imaging, a respiratory gated T1 weighted FLASH sequence was used with repetition time TR ?

Positive_regulation (used) of Gene_expression (imaging) of MR in respiratory associated with imagery

5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952595 Disease Relevance 0.17 Pain Relevance 0.28

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