INT90315

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Context Info
Confidence 0.55
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.00
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
respiratory 2
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 36 100.00 Very High Very High Very High
antidepressant 12 99.98 Very High Very High Very High
5HT 8 99.76 Very High Very High Very High
cerebral cortex 1 95.20 Very High Very High Very High
antagonist 4 92.24 High High
noradrenaline 5 90.16 High High
Serotonin 1 89.04 High High
corticosteroid 19 87.88 High High
monoamine 2 87.08 High High
fluoxetine 3 85.60 High High
Disease Link Frequency Relevance Heat
Stress 108 99.08 Very High Very High Very High
Syndrome 4 95.60 Very High Very High Very High
Post-traumatic Stress Disorder 54 94.24 High High
Anxiety Disorder 20 93.28 High High
Attention Deficit Hyperactivity Disorder 3 79.24 Quite High
Depression 5 68.40 Quite High
Cognitive Disorder 2 68.36 Quite High
Injury 11 65.20 Quite High
INFLAMMATION 11 53.56 Quite High
Vasculitis 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MR mRNA expression was induced in hippocampal CA1/CA2 subregions (27-37%) by all antidepressants, while moclobemide and 8-OH-DPAT significantly increased GR gene expression mainly in the CA1 region (31-44%).
Positive_regulation (induced) of Gene_expression (expression) of MR mRNA associated with antidepressant
1) Confidence 0.55 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.32
It is not known whether homodimers, heterodimers, or both caused the decreased expression of MR and GR.
Spec (whether) Positive_regulation (caused) of Gene_expression (expression) of MR
2) Confidence 0.45 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.50 Pain Relevance 0.11
Antidepressants increase expression of hippocampal MR and decrease basal and stress-induced HPA activity.
Positive_regulation (increase) of Gene_expression (expression) of MR associated with stress and antidepressant
3) Confidence 0.39 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.12 Pain Relevance 0.18
Exposure of hippocampal cells to 5HT for 4 days increased both glucocorticoid and mineralocorticoid receptor mRNA and protein expression.
Positive_regulation (increased) of Gene_expression (expression) of mineralocorticoid receptor associated with 5ht
4) Confidence 0.03 Published 2003 Journal Neuroscience Section Abstract Doc Link 12732243 Disease Relevance 0.21 Pain Relevance 0.93
For MR imaging, a respiratory gated T1 weighted FLASH sequence was used with repetition time TR ?
Positive_regulation (used) of Gene_expression (imaging) of MR in respiratory associated with imagery
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952595 Disease Relevance 0.17 Pain Relevance 0.28

General Comments

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