INT9032

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Context Info
Confidence 0.60
First Reported 1992
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 11
Total Number 15
Disease Relevance 2.77
Pain Relevance 7.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr2c) nucleus (Htr2c) cytoplasm (Htr2c)
signal transducer activity (Htr2c)
Anatomy Link Frequency
MT2 1
nucleus accumbens 1
choroid plexus 1
striatum 1
lever 1
Htr2c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 73 100.00 Very High Very High Very High
Serotonin 31 100.00 Very High Very High Very High
agonist 24 100.00 Very High Very High Very High
5HT 20 100.00 Very High Very High Very High
antagonist 17 100.00 Very High Very High Very High
Dopamine 6 99.96 Very High Very High Very High
antidepressant 97 99.66 Very High Very High Very High
adenocard 2 99.66 Very High Very High Very High
Migraine 3 98.92 Very High Very High Very High
IPN 3 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 13 100.00 Very High Very High Very High
Headache 25 98.92 Very High Very High Very High
Weight Gain 7 98.76 Very High Very High Very High
Sleep Disorders 22 98.12 Very High Very High Very High
Inflammatory Pain 3 98.04 Very High Very High Very High
Anxiety Disorder 28 95.16 Very High Very High Very High
Reprotox - General 2 8 88.80 High High
Pain 2 84.80 Quite High
Hepatic Insufficiency 10 84.48 Quite High
Depression 104 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These differences in the regulation of the 5-HT2C receptors may lead to pharmacodynamic differences between chronic citalopram and fluoxetine treatments.
Regulation (regulation) of 5-HT2C associated with fluoxetine
1) Confidence 0.60 Published 1996 Journal Neuropsychopharmacology Section Abstract Doc Link 8840350 Disease Relevance 0 Pain Relevance 0.67
When administered chronically, many antidepressants elicit adaptive regulation of 5-HT2C receptors.
Regulation (regulation) of 5-HT2C associated with antidepressant
2) Confidence 0.60 Published 2005 Journal Pharmacol. Res. Section Abstract Doc Link 15749456 Disease Relevance 0 Pain Relevance 0.68
The purpose of the present study was to analyze the influence of stress (24-h cold exposure) on presynaptic 5-HT1A receptors, and on postsynaptic 5-HT1A, 5-HT1C and 5-HT2 receptors.
Spec (analyze) Regulation (influence) of 5-HT1C associated with stress
3) Confidence 0.44 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1385172 Disease Relevance 0.17 Pain Relevance 0.16
Trazodone also has 5HT2A and 5HT2C receptor antagonist effects.
Regulation (effects) of 5HT2C associated with antagonist
4) Confidence 0.44 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 0.76 Pain Relevance 0.44
Therefore, we next examined whether 5-HT2A and 5-HT2C receptors are involved, and from where 5-HT is released in the formalin test.
Spec (whether) Regulation (involved) of 5-HT2C
5) Confidence 0.44 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18656400 Disease Relevance 0.41 Pain Relevance 0.45
The present study was conducted in order to determine the effects of acute and chronic fluoxetine and citalopram treatments on the density and function of 5-HT2C receptors in the rat choroid plexus.
Spec (determine) Regulation (effects) of 5-HT2C in choroid plexus associated with fluoxetine
6) Confidence 0.44 Published 2005 Journal Pharmacol. Res. Section Abstract Doc Link 15749456 Disease Relevance 0 Pain Relevance 0.74
5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum.
Regulation (modulate) of 5-HT2C in nucleus accumbens associated with nucleus accumbens, dopamine and morphine
7) Confidence 0.44 Published 2002 Journal Neuropsychopharmacology Section Title Doc Link 11850146 Disease Relevance 0 Pain Relevance 0.71
The present study evaluated the effects of the selective serotonin (5-hydroxyhyptamine; 5-HT) reuptake inhibitor, fluoxetine, the 5-HT1B receptor agonist, tetrahydro-4-pyridyl[3,2-b]pyridine, CP-94,253 the preferential 5-HT2A receptor agonist, 1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane, DOI and the mixed 5-HT2C/1B receptor agonist, 1-(3-chlorophenyl)piperazine, mCPP, on oral ethanol (10% v/v) self-administration in a two-lever, fixed-ratio:1, water vs. ethanol choice procedure in the rat.
Regulation (effects) of 5-HT2C in lever associated with agonist, serotonin and fluoxetine
8) Confidence 0.44 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10334495 Disease Relevance 0 Pain Relevance 0.36
The pharmacological activity of the metabolites for 5HT-2C, MT1, and MT2 receptors is not clearly established.
Regulation (metabolites) of 5HT-2C in MT2 associated with 5ht
9) Confidence 0.44 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 0.22 Pain Relevance 0.05
We further revealed that altered RNA editing in the LH rats and by antidepressants was not explained by altered expression of RNA editing enzymes or their substrates (adenosine deaminases that act on RNA, HTR2C, and spliced form of HTR2C).
Regulation (act) of HTR2C associated with adenocard and antidepressant
10) Confidence 0.27 Published 2005 Journal Neurosci. Res. Section Abstract Doc Link 16005997 Disease Relevance 0.22 Pain Relevance 0.58
In humans, a bolus dose of mCPP can cause alcohol craving (in abstinent alcoholics) and migraine (in susceptible persons), suggesting that there is a 5-HT2C receptor hyperresponsiveness in these conditions also.
Regulation (hyperresponsiveness) of 5-HT2C associated with migraine and alcohol
11) Confidence 0.26 Published 1997 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 9403358 Disease Relevance 0.49 Pain Relevance 0.70
We further revealed that altered RNA editing in the LH rats and by antidepressants was not explained by altered expression of RNA editing enzymes or their substrates (adenosine deaminases that act on RNA, HTR2C, and spliced form of HTR2C).
Regulation (act) of HTR2C associated with adenocard and antidepressant
12) Confidence 0.24 Published 2005 Journal Neurosci. Res. Section Abstract Doc Link 16005997 Disease Relevance 0.22 Pain Relevance 0.58
Effects of cold stress on some 5-HT1A, 5-HT1C and 5-HT2 receptor-mediated responses.
Regulation (Effects) of 5-HT1C associated with stress
13) Confidence 0.19 Published 1992 Journal Eur. J. Pharmacol. Section Title Doc Link 1385172 Disease Relevance 0.20 Pain Relevance 0.24
5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum.
Regulation (modulate) of 5-HT2C in striatum associated with nucleus accumbens, dopamine and morphine
14) Confidence 0.15 Published 2002 Journal Neuropsychopharmacology Section Title Doc Link 11850146 Disease Relevance 0 Pain Relevance 0.71
At PD28, neither 5-HT2A/2C receptor density nor 5-HT2A/2C receptor-mediated endocrine responses were altered by prenatal exposure to fluoxetine.
Regulation (altered) of 2C receptor associated with fluoxetine
15) Confidence 0.05 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8182530 Disease Relevance 0.08 Pain Relevance 0.74

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