INT9034

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Context Info
Confidence 0.20
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.28
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pcbd1) nucleolus (Pcbd1) nucleus (Pcbd1)
molecular_function (Pcbd1) cellular_component (Pcbd1) biological_process (Pcbd1)
Anatomy Link Frequency
cardiac muscle 1
plasma 1
arms 1
apoptotic cell 1
Pcbd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 29 98.48 Very High Very High Very High
potassium channel 6 90.48 High High
Nicotine 2 90.32 High High
depression 39 50.00 Quite Low
addiction 5 50.00 Quite Low
Opioid 2 50.00 Quite Low
Crohn's disease 2 46.00 Quite Low
agonist 1 45.92 Quite Low
anesthesia 1 25.00 Low Low
Inflammation 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 330 100.00 Very High Very High Very High
Coronary Heart Disease 12 98.52 Very High Very High Very High
Cv Unclassified Under Development 15 97.96 Very High Very High Very High
Encephalopathy 14 97.88 Very High Very High Very High
Death 72 97.28 Very High Very High Very High
Hypoglycemia 2 94.36 High High
Muscle Disease 6 92.12 High High
Neurodegenerative Disease 28 89.12 High High
Calcification 2 88.08 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 38 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There were minimal changes in the ECG and no change in the level of plasma alpha-hydroxy-butyrate-dehydrogenase, a cardiac specific enzyme which increases during ischaemia.
Neg (no) Regulation (change) of alpha-hydroxy-butyrate-dehydrogenase in plasma associated with cv unclassified under development
1) Confidence 0.20 Published 1992 Journal J Auton Pharmacol Section Abstract Doc Link 1385437 Disease Relevance 0.19 Pain Relevance 0.05
Three tissues/organs are affected in PCD: cardiac muscle which leads to progressive cardiomyopathy; central nervous system which is affected by encephalopathy caused by hypoketotic hypoglycaemia, and skeletal muscle which is affected by myopathy [30].
Regulation (affected) of PCD in cardiac muscle associated with hypoglycemia, encephalopathy, muscle disease, central nervous system and coronary heart disease
2) Confidence 0.09 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2861661 Disease Relevance 0.62 Pain Relevance 0.05
The gene responsible for PCD is SLC22A5.
Regulation (responsible) of PCD
3) Confidence 0.06 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2861661 Disease Relevance 0.57 Pain Relevance 0.04
In this review, we shall looked into the molecular protein machineries involved in the execution of AVD in the central nervous system (CNS), and focus on the significance of movements of each cellular component in affecting PCD commitment, thus provide some pharmacological advantages in the global apoptotic cell death.



Regulation (affecting) of PCD in apoptotic cell associated with central nervous system, apoptosis and death
4) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Abstract Doc Link PMC2647147 Disease Relevance 0.68 Pain Relevance 0.14
Programmed cell death (PCD), is a highly regulated and sophisticated cellular mechanism that commits cell to isolated death fate.
Regulation (regulated) of PCD associated with apoptosis and death
5) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Abstract Doc Link PMC2647147 Disease Relevance 0.78 Pain Relevance 0
ASImed, MAP-MHS, MAP-PHS, EQ-VAS, and EQ-5D were all responsive to decreases in illicit drug use.
Regulation (responsive) of MAP-PHS
6) Confidence 0.01 Published 2010 Journal J Clin Epidemiol Section Body Doc Link 20236799 Disease Relevance 0 Pain Relevance 0
There was neither change of PHS across the four time-points (p=0.15) nor between the two arms of randomization (p=0.45) (Fig. 1b).
Neg (neither) Regulation (change) of PHS in arms
7) Confidence 0.01 Published 2009 Journal The Open AIDS Journal Section Body Doc Link PMC2757643 Disease Relevance 0.44 Pain Relevance 0

General Comments

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