INT90351

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.85
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast)
Anatomy Link Frequency
plasma 1
G cell 1
Gast (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 6 98.00 Very High Very High Very High
Inflammation 15 96.64 Very High Very High Very High
imagery 2 93.28 High High
isoflurane 38 90.08 High High
peptic ulcer disease 3 88.00 High High
nMDA receptor 24 77.20 Quite High
antagonist 8 75.00 Quite High
potassium channel 6 72.56 Quite High
analgesia 6 69.32 Quite High
Inflammatory mediators 5 67.36 Quite High
Disease Link Frequency Relevance Heat
Syndrome 1 99.68 Very High Very High Very High
Infection 49 99.30 Very High Very High Very High
INFLAMMATION 23 96.64 Very High Very High Very High
Cancer 11 95.20 Very High Very High Very High
Helicobacter Infection 5 92.32 High High
Toxicity 3 89.80 High High
Stomach Cancer 6 88.72 High High
Disease 4 88.00 High High
Ulcers 3 87.68 High High
Thyroid Neoplasm 1 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single dose administration of RC-3095 at the highest dose level (96 ug/kg) was tested in a clearly hypergastrinemic individual with the Zollingen-Ellison syndrome and produced a decrease in plasma gastrin down to 50% of basal levels in 6 h.
Negative_regulation (decrease) of gastrin in plasma associated with syndrome
1) Confidence 0.59 Published 2006 Journal Invest New Drugs Section Abstract Doc Link 16505950 Disease Relevance 0.67 Pain Relevance 0.07
H. felis infection in C57BL/6 mice leads to an early suppression of G cell number and gastrin mRNA.
Negative_regulation (suppression) of gastrin mRNA in G cell associated with infection
2) Confidence 0.58 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10961708 Disease Relevance 0.67 Pain Relevance 0.20
In H. felis-infected mice, gastrin mRNA declined at four and six weeks after infection to 57% and 23%, respectively, of uninfected control values.
Negative_regulation (declined) of gastrin mRNA associated with infection
3) Confidence 0.43 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10961708 Disease Relevance 0.77 Pain Relevance 0.21
Some of the Cox-2 dependent genes from this study have been previously identified as being influenced by Cox-2 or Cox-2 inhibition (Gast, Icam1, Odc), but the remainder are novel and point to new links between Cox-2 and inflammatory processes, epithelial repair and integrity.
Negative_regulation (inhibition) of Gast associated with inflammation
4) Confidence 0.33 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.61 Pain Relevance 0.18
One is by mutating an amino acid at the putative binding site to Cys, and then measuring the reactivity of sulphydryl reagents in the presence and absence of GAs.
Negative_regulation (absence) of GAs
5) Confidence 0.12 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.05
How are the different receptor subtypes distributed on different pathways, and how does this distribution, and their diverse functions, relate to the different effects of the GAs?
Negative_regulation (effects) of GAs
6) Confidence 0.12 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0.14 Pain Relevance 0.19

General Comments

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