INT90354

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.24
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
skin 1
nucleus 1
Myc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 2 95.80 Very High Very High Very High
Chronic pancreatitis 1 89.68 High High
cytokine 3 88.28 High High
Paracetamol 1 88.08 High High
withdrawal 1 84.88 Quite High
endometriosis 46 58.64 Quite High
addiction 4 55.68 Quite High
agonist 10 52.16 Quite High
pain pelvic 2 34.56 Quite Low
antagonist 2 29.92 Quite Low
Disease Link Frequency Relevance Heat
Repression 5 100.00 Very High Very High Very High
Bullous Skin Disease 608 97.80 Very High Very High Very High
Myocardial Infarction 1 97.60 Very High Very High Very High
Breast Cancer 5 96.88 Very High Very High Very High
Reperfusion Injury 2 96.56 Very High Very High Very High
Coronary Artery Disease 1 95.80 Very High Very High Very High
Disease 45 94.40 High High
Stress 14 93.08 High High
Acantholysis 130 92.68 High High
Apoptosis 123 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In consequence, GSK3 phosphorylation-dependent degradation of plakoglobin is abolished which allows plakoglobin to translocate into the nucleus and to induce growth arrest via suppression of c-Myc (Muller et al. 2008a; Williamson et al. 2006).


Negative_regulation (suppression) of c-Myc in nucleus
1) Confidence 0.57 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.58 Pain Relevance 0.03
Because pharmacologic inhibition of c-Myc as well as of plakoglobin degradation by blocking GSK 3 abrogated pemphigus-IgG-induced skin blistering, these results indicate that this mechanism could also be important to induce acantholysis.
Negative_regulation (inhibition) of c-Myc in skin associated with acantholysis and bullous skin disease
2) Confidence 0.57 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.20 Pain Relevance 0.03
Furthermore, p-ERK1/2 downregulation is followed by a downstream reduction of c-Myc, which might contribute to the aforementioned G1 arrest.
Negative_regulation (reduction) of c-Myc
3) Confidence 0.57 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.48 Pain Relevance 0
plays a central role in maintaining the homeostasis through limitation of growth by repression of growth-promoting transcription factors, such as c-Myc [7].
Negative_regulation (repression) of c-Myc associated with repression
4) Confidence 0.42 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1262771 Disease Relevance 0.37 Pain Relevance 0.12
For example, there is the down-regulation of cyclin D1, cyclin-dependent kinase 4, c-myc and Bcl-2 [19, 24].
Negative_regulation (regulation) of c-myc
5) Confidence 0.42 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0.09 Pain Relevance 0
In addition, c-Myc and PCNA levels were also reduced (Fig 5A).
Negative_regulation (reduced) of c-Myc
6) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.44 Pain Relevance 0
GSPE was also shown to upregulate bcl(2) gene and downregulate the oncogene c-myc.
Negative_regulation (downregulate) of c-myc
7) Confidence 0.41 Published 2000 Journal Toxicology Section Abstract Doc Link 10962138 Disease Relevance 1.08 Pain Relevance 0.23

General Comments

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