INT90364

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.59
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (SDC1) small molecule metabolic process (SDC1) extracellular region (SDC1)
plasma membrane (SDC1) protein complex (SDC1) lipid metabolic process (SDC1)
SDC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 6 99.00 Very High Very High Very High
Crohn's disease 9 98.80 Very High Very High Very High
spastic colon 1 67.92 Quite High
Inflammation 1 52.96 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 16 99.64 Very High Very High Very High
Pancreatitis 6 99.00 Very High Very High Very High
Disease 9 98.80 Very High Very High Very High
Gastrointestinal Neoplasms 2 98.72 Very High Very High Very High
Liver Cancer 4 92.04 High High
Cancer 8 82.48 Quite High
Necrosis 2 75.00 Quite High
Functional Bowel Disorder 1 67.92 Quite High
Adhesions 1 55.20 Quite High
INFLAMMATION 1 52.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Syndecan-1 expression is up-regulated in pancreatic but not in other gastrointestinal cancers.
Positive_regulation (up-regulated) of Gene_expression (expression) of Syndecan-1 associated with gastrointestinal neoplasms
1) Confidence 0.70 Published 2000 Journal Int. J. Cancer Section Title Doc Link 10962434 Disease Relevance 0.65 Pain Relevance 0.14
Pancreatic cancer tissues markedly over-expressed syndecan-1 mRNA in comparison with both chronic pancreatitis (2.4-fold increase, p < 0.01) and normal pancreatic samples (10.6-fold increase, p < 0.01).
Positive_regulation (over-expressed) of Gene_expression (expressed) of syndecan-1 mRNA associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.50 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 10962434 Disease Relevance 0.93 Pain Relevance 0.25
In conclusion, TNFalpha and syndecan-1 expression is increased in the intestinal mucosa of patients with CD.
Positive_regulation (increased) of Gene_expression (expression) of syndecan-1 associated with crohn's disease
3) Confidence 0.05 Published 2006 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 16873088 Disease Relevance 1.01 Pain Relevance 0.44

General Comments

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