INT90370

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 3.71
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mmp14)
Anatomy Link Frequency
brain 1
lung 1
Mmp14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 63 100.00 Very High Very High Very High
Inflammation 1 91.96 High High
anesthesia 6 89.44 High High
halothane 1 89.00 High High
ischemia 3 83.84 Quite High
Pain 2 77.76 Quite High
cytokine 6 75.00 Quite High
dexamethasone 45 50.00 Quite Low
fibrosis 5 47.56 Quite Low
Disease Link Frequency Relevance Heat
Bronchopulmonary Dysplasia 305 100.00 Very High Very High Very High
Necrosis 9 100.00 Very High Very High Very High
Cancer 7 100.00 Very High Very High Very High
Dupuytren's Disease 4 99.64 Very High Very High Very High
Stroke 1 98.48 Very High Very High Very High
Respiratory Disease 10 95.20 Very High Very High Very High
Pulmonary Disease 20 92.64 High High
INFLAMMATION 1 91.96 High High
Lung Cancer 5 91.44 High High
Middle Cerebral Artery Infarction 1 85.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP14 gene expression increased at the time of peak alveolarization but rapidly returned to the basal level as early as 16 days of life [7].
Gene_expression (expression) of MMP14 gene
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0 Pain Relevance 0
The different expression profiles of MMP14 and MMP16 suggest primary involvement of the former in the first step and of the latter in the whole process, including the second step.
Gene_expression (expression) of MMP14
2) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.05 Pain Relevance 0
No significant association was found between the MMP2 or MMP14 genotypes and MMP2 activity in tracheal aspirates (data not shown).


Gene_expression (genotypes) of MMP14
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.35 Pain Relevance 0
We found that the pulmonary MMP16 expression profile differed from that of MMP14 in lung fibroblasts from newborn rats.
Gene_expression (expression) of MMP14 in lung
4) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0 Pain Relevance 0
No association was found between the risk of BPD and SNPs in the MMP2 or MMP14 gene.
Gene_expression (risk) of MMP14 gene associated with bronchopulmonary dysplasia
5) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 1.19 Pain Relevance 0
Stroke index score, infarct volume, cerebral specific gravity, and the endogenous expression of tumor necrosis factor-alpha, matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in the brain tissue were quantified in the ischemic and matched contralateral nonischemic hemisphere.
Gene_expression (expression) of membrane type 1-MMP in brain associated with necrosis, cancer, stroke and metalloproteinase
6) Confidence 0.09 Published 2005 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15729288 Disease Relevance 1.63 Pain Relevance 0.56
The notable exception compared with control and Dupuytren's tissue was the absence of MMP-14, which is known to be a membrane-type MMP required for the activation of MMP-2 (gelatinase A).
Neg (absence) Gene_expression (absence) of MMP-14 associated with dupuytren's disease
7) Confidence 0.05 Published 2000 Journal J Bone Joint Surg Br Section Abstract Doc Link 10963182 Disease Relevance 0.48 Pain Relevance 0.37

General Comments

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