INT90371

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Context Info
Confidence 0.05
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 19.11
Pain Relevance 10.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
microglia 4
T cell 3
lymphocytes 2
shoulders 1
immune cells 1
Hrec (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 743 100.00 Very High Very High Very High
Inflammation 560 100.00 Very High Very High Very High
chemokine 73 100.00 Very High Very High Very High
metalloproteinase 22 99.52 Very High Very High Very High
agonist 28 99.46 Very High Very High Very High
Central nervous system 113 98.64 Very High Very High Very High
Spontaneous pain 5 97.68 Very High Very High Very High
rheumatoid arthritis 185 97.42 Very High Very High Very High
Spinal cord 70 96.82 Very High Very High Very High
medulla 16 96.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 582 100.00 Very High Very High Very High
Asthma 418 99.68 Very High Very High Very High
Cancer 163 99.68 Very High Very High Very High
Alzheimer's Dementia 200 99.56 Very High Very High Very High
Melioidosis 57 99.46 Very High Very High Very High
Necrosis 36 99.44 Very High Very High Very High
Drug Induced Neurotoxicity 7 98.92 Very High Very High Very High
Disease 431 98.04 Very High Very High Very High
Pain 14 97.68 Very High Very High Very High
Targeted Disruption 87 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
asthma, including the secretion of cytokines such as IL-4, IL-5, and IL-13,
Localization (secretion) of cytokines associated with asthma and cytokine
1) Confidence 0.05 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.49 Pain Relevance 0.10
In conclusion, the present study points out a slight potential role for PTPH1 in spontaneous pain sensitivity and it indicates that this phosphatase might play a role in the positive regulation of the LPS-induced cytokines release in vivo, in contrast to previous reports indicating PTPH1 as potential negative regulator of immune response.



Localization (release) of cytokines associated with pain, spontaneous pain and cytokine
2) Confidence 0.04 Published 2010 Journal J Inflamm (Lond) Section Abstract Doc Link PMC2873500 Disease Relevance 0.51 Pain Relevance 0.57
expression and release these cytokines/chemokines [38].
Localization (release) of cytokines associated with chemokine and cytokine
3) Confidence 0.04 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.65 Pain Relevance 0.43
In ALS, in the brainstem and spinal cord of both patient and animal models, increasingly large numbers of activated microglia and astrocytes, IgG, and T lymphocytes [13], [34]–[36] may be capable of secreting the numerous cytokines playing key roles in the inflammatory reaction.
Localization (secreting) of cytokines in astrocytes associated with medulla, inflammation, motor neuron diseases, cytokine and spinal cord
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.72 Pain Relevance 0.39
Supernatants were harvested after 42 h and analyzed for levels of secreted cytokines using standard sandwich ELISA procedures as previously described [16].
Localization (secreted) of cytokines associated with cytokine
5) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.05 Pain Relevance 0.08
Cells of naïve mice did not secrete measurable amounts of cytokines (data not shown).
Neg (not) Localization (secrete) of cytokines associated with cytokine
6) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.86 Pain Relevance 0.22
Moreover, activated NK cells can secrete several cytokines, including IFN-?
Localization (secrete) of cytokines in NK cells associated with cytokine
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938346 Disease Relevance 0.22 Pain Relevance 0.26
TH1 and TH2 cytokines refer to the patterns of cytokines secreted by two different subpopulations of CD4+ T cells that determine the outcome of an antigenic response toward humoral and cell-mediated immunity, respectively.
Localization (secreted) of cytokines in T cells associated with cytokine
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938346 Disease Relevance 0.28 Pain Relevance 0.30
On the other hand, T cell secreted cytokines could be detrimental or protective to the joints, perhaps depending on the phase of the clinical disease.
Localization (secreted) of cytokines in T cell associated with disease and cytokine
9) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.33 Pain Relevance 0.78
B cells can contribute to the disease pathogenesis as antigen presenting cells, through costimulatory functions (surface molecules and secreted cytokines), by supporting neolymphogenesis, as well as through its secretory products, immunoglobulins.
Localization (secreted) of cytokines in B cells associated with disease and cytokine
10) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.01 Pain Relevance 0.39
Effector cells of the innate immune system (neutrophils, macrophages and mast cells) drawn to the inflammatory foci by different chemokines and chemoattractants are actively engaged in these models to induce inflammation, inflict damage on the cartilage and perpetuate the ongoing immune responses by secreting cytokines and proteases.
Localization (secreting) of cytokines in immune system associated with chemokine, inflammation and cytokine
11) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 0.86 Pain Relevance 0.47
Our aim was to determine whether there was an abnormal expression or secretion of cytokines, growth factors and MMPs in tissue samples from 14 patients with frozen shoulder using the reverse transcription/polymerase chain reaction (RT/PCR) technique and to compare the findings with those in tissue from four normal control shoulders and from five patients with Dupuytren's contracture.
Localization (secretion) of cytokines in shoulders associated with dupuytren's disease, metalloproteinase, contracture and cytokine
12) Confidence 0.02 Published 2000 Journal J Bone Joint Surg Br Section Abstract Doc Link 10963182 Disease Relevance 0.32 Pain Relevance 0.47
Together with Ruslan Mezhitov, he originated the concept that these phagocytic innate immune cells recognize pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors, the most notable examples being a set of phylogenetically conserved, germ-line encoded Toll-like receptors (TLRs, currently 11–12 members, [7-10]), resulting in expression of cell-surface activation molecules [for example, major histocompatibility complex (MHC) class I and II, B7.1, B7.2, and CD40] and secretion of innate cytokines [i.e., tumor necrosis factor ?
Localization (secretion) of cytokines in immune cells associated with necrosis, cancer and cytokine
13) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.20 Pain Relevance 0.05
Furthermore, murine microglia respond to the TLR9 agonist, unmethylated CpG-DNA, by secreting numerous pro-inflammatory innate cytokines (probably responsible for neurotoxicity in oganotypic brain slice cultures treated with CpG-DNA [35]), by up-regulating co-stimulatory cell surface molecules, and by promoting adaptive activation by secreting IL-12 to affect T cell activation [36].
Localization (secreting) of cytokines in T cell associated with drug induced neurotoxicity, inflammation, agonist and cytokine
14) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.54 Pain Relevance 0.47
DCs then up-regulate cell-surface co-stimulatory molecules and secrete innate cytokines and chemokines (typically at levels an order of magnitude higher than those secreted by M?
Localization (secrete) of cytokines associated with chemokine and cytokine
15) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.36 Pain Relevance 0.31
In terms of innate responses, PAMP-stimulated microglia clearly secrete pro-inflammatory innate cytokines (i.e., TNF-?
Localization (secrete) of cytokines in microglia associated with inflammation and cytokine
16) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.18 Pain Relevance 0.14
It has been suggested that activated microglia play a key role in AD pathogenesis as they secrete pro-inflammatory innate cytokines such as TNF-?
Localization (secrete) of cytokines in microglia associated with inflammation, alzheimer's dementia and cytokine
17) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 1.98 Pain Relevance 0.35
DCs then up-regulate cell-surface co-stimulatory molecules and secrete innate cytokines and chemokines (typically at levels an order of magnitude higher than those secreted by M?
Localization (secreted) of cytokines associated with chemokine and cytokine
18) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.35 Pain Relevance 0.33
The fetal and maternal placental tissues secrete a variety of cytokines, including “acute-phase” cytokines [interleukin (IL)-6, IL-10] and “anti-TH1” cytokines [IL-4, IL-10, IL-13, tumor growth factor 2 (TGF2)].
Localization (secrete) of cytokines associated with cancer and cytokine
19) Confidence 0.01 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 0.94 Pain Relevance 0.22
The fetal and maternal placental tissues secrete a variety of cytokines, including “acute-phase” cytokines [interleukin (IL)-6, IL-10] and “anti-TH1” cytokines [IL-4, IL-10, IL-13, tumor growth factor 2 (TGF2)].
Localization (secrete) of cytokines associated with cancer and cytokine
20) Confidence 0.01 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 0.94 Pain Relevance 0.23

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