INT90372

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Context Info
Confidence 0.03
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 11.73
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
shoulders 1
glial cells 1
spinal cord 1
brain 1
fibroblast 1
Hrec (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 316 100.00 Very High Very High Very High
Inflammation 190 100.00 Very High Very High Very High
antagonist 14 99.96 Very High Very High Very High
Arthritis 175 99.72 Very High Very High Very High
cINOD 4 99.54 Very High Very High Very High
Spinal cord 105 99.28 Very High Very High Very High
chemokine 30 98.64 Very High Very High Very High
rheumatoid arthritis 174 98.28 Very High Very High Very High
Inflammatory mediators 5 98.12 Very High Very High Very High
Inflammatory response 14 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 184 100.00 Very High Very High Very High
Birth Weight 2 99.96 Very High Very High Very High
Death 20 99.88 Very High Very High Very High
Systemic Lupus Erythematosus 119 99.84 Very High Very High Very High
Arthritis 184 99.72 Very High Very High Very High
Cancer 59 99.24 Very High Very High Very High
Necrosis 20 98.64 Very High Very High Very High
Disease Progression 42 98.44 Very High Very High Very High
Adhesions 12 98.38 Very High Very High Very High
Apoptosis 12 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most beneficial effect on decreasing pro-inflammatory cytokines in the brain and spinal cord was found in this group of mice.
Negative_regulation (decreasing) of cytokines in brain associated with inflammation, spinal cord and cytokine
1) Confidence 0.03 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2429976 Disease Relevance 0.78 Pain Relevance 0.27
way of reducing these cytokines.
Negative_regulation (reducing) of cytokines associated with cytokine
2) Confidence 0.02 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.70 Pain Relevance 0.44
Since proinflammatory cytokines may be indirect mediators for glial cells' contribution to motoneuron death, the decrease of these macrophage-cytokines might be due to a reduction of activated microglia and astrocytes by administration of the 25×106 MNC hUCB cells.
Negative_regulation (decrease) of cytokines in glial cells associated with death and cytokine
3) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.10 Pain Relevance 0.37
downregulates the proinflammatory cytokines IL-1?
Negative_regulation (downregulates) of cytokines associated with cytokine
4) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416442 Disease Relevance 0.65 Pain Relevance 0.41
and IL-1 are critical mediators in the inflammatory process of arthritis [57,58], and neutralizing these effector cytokines has proven successful in the treatment of RA.
Negative_regulation (neutralizing) of cytokines associated with inflammation, rheumatoid arthritis, cytokine and arthritis
5) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.88 Pain Relevance 0.92
The most beneficial effect on decreasing pro-inflammatory cytokines in the brain and spinal cord was found in this group of mice.
Negative_regulation (decreasing) of cytokines in spinal cord associated with inflammation, spinal cord and cytokine
6) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2429976 Disease Relevance 0.78 Pain Relevance 0.27
Tissue from frozen shoulders demonstrated the presence of mRNA for a large number of cytokines and growth factors although the frequency was only slightly higher than in the control tissue.
Negative_regulation (number) of cytokines in shoulders associated with cytokine
7) Confidence 0.01 Published 2000 Journal J Bone Joint Surg Br Section Abstract Doc Link 10963182 Disease Relevance 0.47 Pain Relevance 0.47
The adverse outcomes include decreased birth weight, decreased cord blood cytokines levels (both TH1 and TH2), increased collagen deposition in airway and alveolar walls, abnormal lung function at birth, and suppressed ventilatory responses to postnatal hypoxia (Sekhon et al. 2002; Ueda et al. 1999).
Negative_regulation (decreased) of cytokines in lung associated with birth weight, hypoxia and cytokine
8) Confidence 0.01 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 1.05 Pain Relevance 0.22
These are (1) “B lymphocyte (BL)” inhibitors such as anti-CD20 monoclonal antibody, anti-CD22 monoclonal antibody, B-lymphocyte stimulator (BlyS) antagonists, tolerogenic peptide [hCDR1: Edratide, which is based on the sequence of the complementary-determining region (CDR)1 of a human anti-DNA monoclonal antibody that bears the major idiotype designated 16/6Id] [7], and LJP 394 (abetimus sodium) which selectively reduces antibodies to dsDNA and their parent B cells via antigen-specific tolerance [1]; (2) “Inhibitors of the costimulation” between antigen-presenting cells and T lymphocyte by monoclonal anti-CD40 ligand antibody or CTLA-4-Ig; (3) “Cytokine antagonists” inhibiting key cytokines of SLE: IL-10 [8], interferon (IFN)-?
Negative_regulation (inhibiting) of cytokines in T lymphocyte associated with antagonist, tolerance, systemic lupus erythematosus and cytokine
9) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 1.10 Pain Relevance 0.27
The pro-survival and proliferative effects of these cytokines may be important in the development of the expanded fibroblast network, which occurs during early disease and which characterizes established RA [46].
Negative_regulation (effects) of cytokines in fibroblast associated with rheumatoid arthritis, disease and cytokine
10) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 1.49 Pain Relevance 0.51
Although the etiopathogenesis of CC is poorly understood, multiple biologic pathways are known to be involved, including pro-inflammatory cytokines [6–8], neuroendocrine hormones [4, 9•], downregulation of IGF-1 [2•] and tumor-specific factors such as proteolysis inducing factor (PIF) [10, 11••].
Negative_regulation (downregulation) of cytokines associated with appetite loss, inflammation, cancer and cytokine
11) Confidence 0.01 Published 2010 Journal Curr Treat Options Oncol Section Body Doc Link PMC3016925 Disease Relevance 1.83 Pain Relevance 0.17
These methods include nonspecific inhibition of pro-inflammatory mediators and adhesion molecules by nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids, inhibition of cytokines and cytokine receptors, and inhibition of specific types of cell adhesion molecules, with inhibitors such as peptides and antibodies to beta2 integrins, and inhibitors of selectins, ICAMs, and vascular cell adhesion molecule-1 (VCAM-1).
Negative_regulation (inhibition) of cytokines associated with inflammatory mediators, inflammation, cinod, adhesions and cytokine
12) Confidence 0.00 Published 2001 Journal J. Vet. Intern. Med. Section Abstract Doc Link 11817056 Disease Relevance 0.90 Pain Relevance 0.42

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