INT90374

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.12
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2)
proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)
Anatomy Link Frequency
lateral 6
monocytes 2
colon 2
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 184 100.00 Very High Very High Very High
ischemia 84 99.98 Very High Very High Very High
dexamethasone 112 98.66 Very High Very High Very High
COX-2 inhibitor 19 97.96 Very High Very High Very High
cINOD 54 95.24 Very High Very High Very High
rheumatoid arthritis 80 94.76 High High
cytokine 29 93.80 High High
Inflammation 150 93.44 High High
cva 72 92.48 High High
Pain 4 85.20 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 60 99.98 Very High Very High Very High
Death 60 99.28 Very High Very High Very High
Prostate Cancer 3 98.72 Very High Very High Very High
Dupuytren's Disease 8 98.44 Very High Very High Very High
Colon Cancer 4 98.00 Very High Very High Very High
Apoptosis 28 97.40 Very High Very High Very High
Stroke 100 97.28 Very High Very High Very High
Rheumatoid Arthritis 80 94.76 High High
Cancer 39 93.72 High High
INFLAMMATION 187 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both C. yanhusuo extract and its active compound berberine significantly suppressed the VEGF-induced upregulation of matrix metalloproteinase 2 (MMP2) at both mRNA and protein levels.
Positive_regulation (induced) of Positive_regulation (upregulation) of MMP2 associated with metalloproteinase
1) Confidence 0.50 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19806782 Disease Relevance 0.07 Pain Relevance 0.12
Both C. yanhusuo extract and its active compound berberine significantly suppressed the VEGF-induced upregulation of matrix metalloproteinase 2 (MMP2) at both mRNA and protein levels.
Positive_regulation (induced) of Positive_regulation (upregulation) of matrix metalloproteinase 2 associated with metalloproteinase
2) Confidence 0.50 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19806782 Disease Relevance 0.07 Pain Relevance 0.12
The notable exception compared with control and Dupuytren's tissue was the absence of MMP-14, which is known to be a membrane-type MMP required for the activation of MMP-2 (gelatinase A).
Positive_regulation (required) of Positive_regulation (activation) of gelatinase A associated with dupuytren's disease
3) Confidence 0.49 Published 2000 Journal J Bone Joint Surg Br Section Abstract Doc Link 10963182 Disease Relevance 0.47 Pain Relevance 0.37
Increased expression and activation of matrix metalloproteinase 2 (MMP-2) is associated with neuroinflammation [37].
Positive_regulation (Increased) of Positive_regulation (activation) of matrix metalloproteinase 2 associated with metalloproteinase
4) Confidence 0.30 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1557842 Disease Relevance 1.39 Pain Relevance 0.65
Recently, we reported that HCSM cells increase their expression and activation of MMP-2 in response to treatment with pathogenic A?
Positive_regulation (increase) of Positive_regulation (activation) of MMP-2
5) Confidence 0.30 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1557842 Disease Relevance 1.18 Pain Relevance 0.41
accumulation it effectively reduces the subsequent pathologic responses including elevated levels of IL-6, MMP-2 activation, and depletion of HCSM ?
Positive_regulation (elevated) of Positive_regulation (activation) of MMP-2
6) Confidence 0.30 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1557842 Disease Relevance 0.42 Pain Relevance 0.39
Similarly, we found that dexamethasone, which reduced HCSM cell death (Figure 1), effectively suppressed increased expression and activation of MMP-2 in response to Dutch mutant A?
Positive_regulation (increased) of Positive_regulation (activation) of MMP-2 associated with dexamethasone and death
7) Confidence 0.26 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1557842 Disease Relevance 1.11 Pain Relevance 0.39
The densitometric analysis revealed also that intra-peritoneal minocycline 45 mg/kg treatment twice a day (first dose immediately after reperfusion), significantly reduced the ischemia-induced increments in both MMP-2 and MMP-9 active gelatinolytic forms (n = 6 for control and 8 for treated animals) (p < 0.0003) (Fig. 2).
Positive_regulation (induced) of Positive_regulation (increments) of MMP-2 associated with ischemia
8) Confidence 0.21 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.61 Pain Relevance 0.20
The 3 hour ischemia followed by 21 hour survival after reperfusion caused increased activity of MMP-2 and MMP-9 in the ischemic hemisphere (Fig. 1) as compared to the contra-lateral hemisphere (n = 8, p < 0.0001 for MMP-9, MMP-2 activity was increased, but not significantly).
Positive_regulation (increased) of Positive_regulation (activity) of MMP-2 in lateral associated with ischemia
9) Confidence 0.19 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.94 Pain Relevance 0.28
The 3 hour ischemia followed by 21 hour survival after reperfusion caused increased activity of MMP-2 and MMP-9 in the ischemic hemisphere (Fig. 1) as compared to the contra-lateral hemisphere (n = 8, p < 0.0001 for MMP-9, MMP-2 activity was increased, but not significantly).
Positive_regulation (caused) of Positive_regulation (activity) of MMP-2 in lateral associated with ischemia
10) Confidence 0.19 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.94 Pain Relevance 0.28
The 3 hour ischemia followed by 21 hour survival after reperfusion caused increased activity of MMP-2 and MMP-9 in the ischemic hemisphere (Fig. 1) as compared to the contra-lateral hemisphere (n = 8, p < 0.0001 for MMP-9, MMP-2 activity was increased, but not significantly).
Positive_regulation (caused) of Positive_regulation (increased) of MMP-2 in lateral associated with ischemia
11) Confidence 0.19 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.94 Pain Relevance 0.28
Our in vitro functional assays of a co-culture of human monocytes or THP-1 cells and fibroblasts reveal a significantly elevated production of MMP-9 and/or MMP-2 and a significant increase in the number of cells invading through the Matrigel layer and filter compared with those in the respective cultures of these cells alone.
Positive_regulation (elevated) of Positive_regulation (increase) of MMP-2 in monocytes associated with metalloproteinase
12) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.63 Pain Relevance 0.67
Tsuji et al. [16] observed an increase in MMP-2 activation and increase in MMP-14 mRNA expression by Caco-2 colon cancer cells, which showed high levels of COX-2.
Positive_regulation (increase) of Positive_regulation (activation) of MMP-2 in colon associated with colon cancer and metalloproteinase
13) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.90 Pain Relevance 0.57
The notable exception compared with control and Dupuytren's tissue was the absence of MMP-14, which is known to be a membrane-type MMP required for the activation of MMP-2 (gelatinase A).
Positive_regulation (required) of Positive_regulation (activation) of MMP-2 associated with dupuytren's disease
14) Confidence 0.08 Published 2000 Journal J Bone Joint Surg Br Section Abstract Doc Link 10963182 Disease Relevance 0.47 Pain Relevance 0.37

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