INT90377

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 7.34
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
endothelial cells 4
T cell 3
blood vessels 2
muscle 1
tube 1
HBA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 7 95.92 Very High Very High Very High
cva 10 92.92 High High
tolerance 20 91.76 High High
Nicotine 237 83.84 Quite High
positron emission tomography 51 79.16 Quite High
Opioid 1 78.56 Quite High
Inflammatory response 35 77.56 Quite High
anesthesia 35 73.92 Quite High
imagery 147 71.56 Quite High
Enkephalin 4 62.48 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 142 100.00 Very High Very High Very High
Adhesions 12 99.68 Very High Very High Very High
Hematuria 16 96.24 Very High Very High Very High
Angina 3 95.92 Very High Very High Very High
Benign Prostatic Hypertrophy 52 95.32 Very High Very High Very High
Cancer 687 93.84 High High
Hemorrhage 17 92.92 High High
Coronary Artery Disease 33 92.48 High High
Impaired Glucose Tolerance 10 92.40 High High
Hemangiosarcoma 5 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical staining demonstrated an intense expression of CD 31, CD 34, factor VIII related antigen and keratin.
Gene_expression (expression) of CD 31
1) Confidence 0.75 Published 2000 Journal Virchows Arch. Section Abstract Doc Link 10963385 Disease Relevance 0.54 Pain Relevance 0.06
In the EPO-treated fat grafts, there were well-vascularized areas with increased expression of CD31, and numerous endothelial islets (Figure 2C and 2D middle).
Gene_expression (expression) of CD31 in fat
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.62 Pain Relevance 0.24
Diabetes, HbA1c, and homoeostasis model assessment
Gene_expression (Diabetes) of HbA1 associated with diabetes mellitus
3) Confidence 0.65 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2806945 Disease Relevance 0.65 Pain Relevance 0.14
Along with ROS, VEGF, and a large number of mature and immature CD31/vWF positive blood vessels were present in the adhesion tissue.
Gene_expression (present) of CD31 in blood vessels associated with adhesions
4) Confidence 0.65 Published 2004 Journal World J Surg Section Abstract Doc Link 14961185 Disease Relevance 1.30 Pain Relevance 0
Donohue and associates published their experience with 64 men scheduled to undergo TURP who were randomized to receive either 5 mg of finasteride or placebo daily for 2 weeks prior to surgery.23 Sections of prostatic urothelium were stained for VEGF expression and for CD31 to assess microvessel density (MVD) (an indicator of prostatic angiogenesis in patients with hematuria secondary to BPH).
Gene_expression (expression) of CD31 associated with benign prostatic hypertrophy and hematuria
5) Confidence 0.39 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710385 Disease Relevance 0.94 Pain Relevance 0
Furthermore, flow cytometric analyses of T-MPCs confirmed the non-hematopoietic and non-endothelial nature of T-MPCs, based on their lack of expression of CD45 and CD31, respectively.
Gene_expression (expression) of CD31
6) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.15 Pain Relevance 0
Cell engraftment was confirmed by identification of GFP and human-specific CD31 expression under fluorescent microscopy.
Gene_expression (expression) of CD31
7) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.18 Pain Relevance 0.23
In order to study the phenotype of CD31+ cells thus obtained, we confirmed the endothelial phenotype of our CD31+ twice-purified hESC-ECs by flow cytometry analysis for the expression of vWF, CD31, and VE-cadherin (BD Biosciences), DiI-ac-LDL uptake assay, and Matrigel tube formation assay as previously described [15].


Gene_expression (expression) of CD31 in tube
8) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.08 Pain Relevance 0
As expected, CD31 and CD144 were upregulated during the two-step differentiation and expressed robustly after sorting (Figure 2A).
Gene_expression (expressed) of CD31
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
CD31/CD144 expression increased swiftly to 10–15% after subculture in collagen as confirmed by FACS analysis, as compared to only 1–2% using the conventional EB culturing technique (Figure 1D).
Gene_expression (expression) of CD31
10) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
After isolation, these hESC-ECs expressed endothelial specific markers such as vWF (96.3±1.4%), CD31 (97.2±2.5%), and VE-cadherin (93.7±2.8%), form vascular-like channels, and incorporated DiI-labeled acetylated low-density lipoprotein (DiI-Ac-LDL).
Spec (like) Gene_expression (expressed) of CD31
11) Confidence 0.25 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2737633 Disease Relevance 0.31 Pain Relevance 0.21
Surface epitope analysis revealed that T-MPCs were negative for CD14, CD31, CD34, and CD45 expression and positive for CD29, CD44, CD90, and CD105 expression, a characteristic phenotype of BM-MPCs.
Gene_expression (expression) of CD31
12) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575631 Disease Relevance 0.06 Pain Relevance 0.06
In order to define at a molecular level the changes occurring at each stage of hESC differentiation into endothelial cells, we next performed transcriptional profiling using whole human genome microarrays on (i) undifferentiated hESCs, (ii) day-12 EBs, (iii) hESC-ECs after CD31/CD144 sort, and (iv) HUVECs as positive control (n?
Gene_expression (sort) of CD31 in endothelial cells
13) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
When CD31+/CD144+ cells were cultured in endothelial growth medium, the majority of cells were adherent and expressed endothelial markers (CD31, CD144) at the endothelial cell adherent junctions as well as von Willebrand factor (vWF) located within the cytoplasm (Figure 2B).
Gene_expression (expressed) of CD31 in endothelial cell
14) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
To track GFP+ hESC-ECs in hearts, rabbit anti-GFP antibody (Invitrogen), rat anti-mouse CD31 antibody (BD Pharmingen), anti-?
Gene_expression (antibody) of CD31 in hearts
15) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0.13 Pain Relevance 0.07
Gating on populations of CD3+CD8+ and CD3+CD4+ T cells, expression of Ki67 or bcl-2 was determined on T cell subsets defined by the following antibody expression patterns: RTEs as CD4+/CD45RA+/CD31+, naive CD4 or CD8 T cells as CD27+ CD45RA+, memory as CD27+CD45RA?
Gene_expression (/) of CD31 in T cell
16) Confidence 0.20 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0.14 Pain Relevance 0
In our separate study, we had generated cell type-specific transcriptomes for prostate CD26+ luminal cells, CD104+ basal cells, CD49a+ stromal cells, and CD31+ endothelial cells through cell sorting and DNA array analysis (unpublished).
Gene_expression (endothelial cells) of CD31 in stromal cells
17) Confidence 0.19 Published 2005 Journal BMC Urol Section Body Doc Link PMC1327674 Disease Relevance 0 Pain Relevance 0.17
Similarly, CD4+ RTEs defined by coexpression of CD45RA and CD31 substantially increased both in frequency and number after rhIL-7 therapy.
Gene_expression (coexpression) of CD31
18) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
CD31 and CD133 were negative in both populations (data not shown).


Neg (negative) Gene_expression (negative) of CD31
19) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.20 Pain Relevance 0
In the open group, CD31 expression was found to be significantly decreased from preoperative baseline levels on the PODs 1 and 3.
Gene_expression (expression) of CD31
20) Confidence 0.12 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2814196 Disease Relevance 0.15 Pain Relevance 0.06

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