INT90387

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Context Info
Confidence 0.32
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.35
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) cell differentiation (ROS1) mitochondrion (NFKB1)
cytoplasm (NFKB1) cell proliferation (ROS1) cytosol (NFKB1)
Anatomy Link Frequency
keratinocytes 2
ROS1 (Homo sapiens)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 98.64 Very High Very High Very High
Inflammatory marker 1 96.44 Very High Very High Very High
Inflammatory response 2 94.88 High High
cINOD 4 83.68 Quite High
cytokine 10 77.68 Quite High
aspirin 1 77.48 Quite High
Osteoarthritis 2 76.44 Quite High
Inflammation 21 75.00 Quite High
metalloproteinase 2 69.52 Quite High
Nicotine 1 56.72 Quite High
Disease Link Frequency Relevance Heat
Atherosclerosis 39 98.70 Very High Very High Very High
INFLAMMATION 22 98.64 Very High Very High Very High
Diabetes Mellitus 53 98.38 Very High Very High Very High
Calcification 98 88.48 High High
Metabolic Syndrome 7 87.28 High High
Atherosclerotic Plaque 3 78.16 Quite High
Injury 8 78.12 Quite High
Osteoarthritis 2 76.44 Quite High
Dermatitis 2 75.00 Quite High
Osteoporosis 7 69.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that ROS, generated during pulmonary metabolism of NNK could act as signal transduction messengers and activate NF-kappaB, which will subsequently induce COX-1 activity and increase PGE(2) synthesis.
ROS Positive_regulation (activate) of NF-kappaB
1) Confidence 0.32 Published 2000 Journal Carcinogenesis Section Abstract Doc Link 10964107 Disease Relevance 0.19 Pain Relevance 0.36
Capsiate-pretreated human keratinocytes inhibited intracellular reactive oxygen species (ROS), which activate the mitogen-activated protein kinase and nuclear factor-kappaB (NF-kappaB) pathways.
ROS Positive_regulation (activate) of NF-kappaB in keratinocytes
2) Confidence 0.08 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20123015 Disease Relevance 0.17 Pain Relevance 0.19
Capsiate-pretreated human keratinocytes inhibited intracellular reactive oxygen species (ROS), which activate the mitogen-activated protein kinase and nuclear factor-kappaB (NF-kappaB) pathways.
ROS Positive_regulation (activate) of nuclear factor-kappaB in keratinocytes
3) Confidence 0.08 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20123015 Disease Relevance 0.17 Pain Relevance 0.18
In atheroscleropathy and non-diabetic atherosclerosis, the multiple metabolic toxicities and the resultant – parallel ROS, via stimulation of the essential and omnipotent nuclear factor (NFkappaB), which activates the downstream inflammatory mediators TNFalpha, IL-1, IL-6, and other inflammatory markers such as C-reactive protein (CRP).
ROS Positive_regulation (stimulation) of NFkappaB associated with inflammatory mediators, atherosclerosis, diabetes mellitus and inflammatory marker
4) Confidence 0.01 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 1.82 Pain Relevance 0.14

General Comments

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