INT90388

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Context Info
Confidence 0.32
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (NFKB1, CPOX) cytoplasm (NFKB1, CPOX) nucleoplasm (NFKB1)
small molecule metabolic process (CPOX) cytosol (NFKB1) signal transduction (NFKB1)
NFKB1 (Homo sapiens)
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 86.56 High High
aspirin 1 73.20 Quite High
Nicotine 1 52.44 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 60.88 Quite High
Nicotine Addiction 2 58.28 Quite High
Lung Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that ROS, generated during pulmonary metabolism of NNK could act as signal transduction messengers and activate NF-kappaB, which will subsequently induce COX-1 activity and increase PGE(2) synthesis.
NF-kappaB Positive_regulation (induce) of COX
1) Confidence 0.32 Published 2000 Journal Carcinogenesis Section Abstract Doc Link 10964107 Disease Relevance 0.18 Pain Relevance 0.35

General Comments

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