INT9039

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 69
Total Number 69
Disease Relevance 9.56
Pain Relevance 41.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
raphe nucleus 4
dorsal 3
hippocampus 2
Pfc 2
frontal cortex 2
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 161 100.00 Very High Very High Very High
antagonist 91 100.00 Very High Very High Very High
Serotonin 89 100.00 Very High Very High Very High
Raphe 69 100.00 Very High Very High Very High
Spinal cord 22 100.00 Very High Very High Very High
fluoxetine 275 99.98 Very High Very High Very High
anesthesia 3 99.98 Very High Very High Very High
GABAergic 54 99.96 Very High Very High Very High
hyperexcitability 3 99.96 Very High Very High Very High
Pyramidal cell 19 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 8 100.00 Very High Very High Very High
Ganglion Cysts 3 99.98 Very High Very High Very High
Depression 99 99.80 Very High Very High Very High
Impotence 14 99.74 Very High Very High Very High
Urological Neuroanatomy 155 99.30 Very High Very High Very High
Injury 11 97.56 Very High Very High Very High
Frailty 5 96.20 Very High Very High Very High
Epilepsy 4 94.44 High High
Pain 20 94.40 High High
Panic Disorder 6 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, in vitro electrophysiological recordings of serotonergic neurons in the dorsal raphe nucleus allowed the demonstration of a clearcut functional desensitization of somatodendritic 5-HT1A autoreceptors.
Negative_regulation (desensitization) of 5-HT1A in raphe nucleus associated with raphe
1) Confidence 0.57 Published 1995 Journal Encephale Section Abstract Doc Link 7781583 Disease Relevance 0 Pain Relevance 0.69
Chronic injections of fluoxetine inhibited the ACTH, corticosterone and oxytocin responses to 8-OH-DPAT, suggesting reduced 5-HT1A receptor function.
Negative_regulation (reduced) of 5-HT1A associated with fluoxetine
2) Confidence 0.57 Published 1993 Journal Brain Res. Section Abstract Doc Link 8118681 Disease Relevance 0.09 Pain Relevance 1.18
Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors.
Negative_regulation (blockade) of 5-HT1A associated with impotence and fluoxetine
3) Confidence 0.57 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9085055 Disease Relevance 0.42 Pain Relevance 0.46
The increase in 5-HT stimulated AC activity in cortex may be due to the significant downregulation of 5-HT1A sites in cortex after fluoxetine exposure as these sites are negatively coupled to AC.
Negative_regulation (downregulation) of 5-HT1A in cortex associated with fluoxetine
4) Confidence 0.57 Published 2000 Journal J Neural Transm Section Abstract Doc Link 10821446 Disease Relevance 0 Pain Relevance 0.65
CONCLUSION: These data demonstrate that the behavioral effects of fluoxetine are modified by 5-HT-1A receptor blockade.


Negative_regulation (blockade) of 5-HT-1A
5) Confidence 0.57 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10928318 Disease Relevance 0 Pain Relevance 0
A significant, non-parallel shift in the dose-response curve of serotonergic neurons to the serotonin-1A (5-HT1A) agonist 8-OH-DPAT occurred over the 21 days of treatment with fluoxetine, indicating a desensitization of the 5-HT1A receptor during this period.
Negative_regulation (desensitization) of 5-HT1A in serotonergic neurons associated with agonist, serotonin and fluoxetine
6) Confidence 0.57 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10997729 Disease Relevance 0 Pain Relevance 0.97
It is concluded that 5-HT1A receptors are down-regulated in the hypothalamus of U-50,488H-abstinent rats but the hypothermic response to 5-HT1A agonist is intensified.
Negative_regulation (down-regulated) of 5-HT1A in hypothalamus associated with agonist
7) Confidence 0.57 Published 1992 Journal Neuropharmacology Section Abstract Doc Link 1470300 Disease Relevance 0 Pain Relevance 0.49
Evidence from animal and clinical studies has suggested that desensitization of HTR1A is implicated in the antidepressant therapeutic mechanism of selective serotonin reuptake inhibitors (SSRIs).
Negative_regulation (desensitization) of HTR1A associated with antidepressant and ssri
8) Confidence 0.53 Published 2006 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16458487 Disease Relevance 0.14 Pain Relevance 0.44
One hour after treatment, there was a 36% decrease in 5-HT1A immunogold labeling of the plasma membrane of NRD dendrites, and a concomitant increase in their cytoplasmic labeling, without any change in hippocampal dendrites.
Negative_regulation (decrease) of 5-HT1A in dendrites
9) Confidence 0.42 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15190115 Disease Relevance 0 Pain Relevance 0.71
Chronic fluoxetine induces a gradual desensitization of 5-HT1A receptors: reductions in hypothalamic and midbrain Gi and G(o) proteins and in neuroendocrine responses to a 5-HT1A agonist.
Negative_regulation (desensitization) of 5-HT1A in midbrain associated with agonist, midbrain and fluoxetine
10) Confidence 0.42 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8930214 Disease Relevance 0.06 Pain Relevance 0.53
Reduced 5-HT1A- and GABAB receptor function in dorsal raphé neurons upon chronic fluoxetine treatment of socially stressed rats.
Negative_regulation (Reduced) of 5-HT1A in dorsal associated with fluoxetine
11) Confidence 0.42 Published 2007 Journal J. Neurophysiol. Section Title Doc Link 17460100 Disease Relevance 0.39 Pain Relevance 0.61
Fluoxetine-induced desensitization of somatodendritic 5-HT1A autoreceptors is independent of glucocorticoid(s).
Negative_regulation (desensitization) of 5-HT1A associated with fluoxetine
12) Confidence 0.42 Published 1997 Journal Synapse Section Title Doc Link 9372553 Disease Relevance 0 Pain Relevance 0.53
In the present study, we investigated whether a link might exist between these effects, i.e., whether glucocorticoid receptor activation could be responsible for the fluoxetine-induced desensitization of 5-HT1A autoreceptors.
Negative_regulation (desensitization) of 5-HT1A associated with fluoxetine
13) Confidence 0.42 Published 1997 Journal Synapse Section Abstract Doc Link 9372553 Disease Relevance 0 Pain Relevance 0.60
The suppressant effects on the firing activity of 5-HT neurons of the 5-HT autoreceptor agonist lysergic acid diethylamide (LSD), injected intravenously, and of both 5-HT and the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), applied by microiontophoresis, were attenuated in rats treated with befloxatone for 2 days, suggesting an early desensitization of the somatodendritic 5-HT1A receptors.
Negative_regulation (desensitization) of 5-HT1A in 5-HT neurons associated with agonist
14) Confidence 0.42 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9570466 Disease Relevance 0 Pain Relevance 0.42
However, an antagonist of 5-HT1A receptors, WAY100635, subsequently injected (s.c.) at 1 mg/kg brought the 5-HT concentrations to similar levels in the Pfc (332%) and Dhp (308%).
Negative_regulation (antagonist) of 5-HT1A in Pfc associated with antagonist and hippocampus
15) Confidence 0.42 Published 1999 Journal Chin J Physiol Section Abstract Doc Link 10513599 Disease Relevance 0 Pain Relevance 0.81
Behavioral evidence indicates that sensitization of 5-HT1A and 5-HT2A receptors in the dorsal periaqueductal gray (DPAG) may underlie the therapeutic effect of serotonin reuptake inhibitors (SRIs) in panic disorder.
Negative_regulation (sensitization) of 5-HT1A in dorsal associated with panic disorder, serotonin and central grey
16) Confidence 0.42 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17313964 Disease Relevance 0.51 Pain Relevance 0.40
These results indicate that bupropion, unlike 5-HT reuptake inhibitors, promptly increased 5-HT neuronal activity, due to early desensitization of the 5-HT1A autoreceptor.
Negative_regulation (desensitization) of 5-HT1A in neuronal
17) Confidence 0.42 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18708076 Disease Relevance 0 Pain Relevance 0.54
Finally, pretreatment with a specific antagonist of 5-HT1A receptors, 4-iodo-N-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-benzamide (3 mg/kg, i.p.; n = 3) given 20 min before 8-OH-DPAT, prevented 8-OH-DPAT from restoring respiration to normal.
Negative_regulation (antagonist) of 5-HT1A associated with antagonist
18) Confidence 0.42 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764106 Disease Relevance 0.65 Pain Relevance 0.33
Finally in fluoxetine, corticosterone, and corticosterone plus fluoxetine groups, there was marked 5-HT1A receptor desensitization, evidenced by attenuation of the decrease in 5-HT release following systemic fluoxetine injection.
Negative_regulation (desensitization) of 5-HT1A associated with fluoxetine
19) Confidence 0.42 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12784107 Disease Relevance 0.15 Pain Relevance 1.13
Chronic fluoxetine increased the basal concentrations of extracellular 5-HT only when a substantial amount of its metabolite was present in the brain and during the desensitization of presynaptic 5-HT1A autoreceptors (24 h after the last dose).
Negative_regulation (desensitization) of 5-HT1A in brain associated with fluoxetine
20) Confidence 0.42 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8728551 Disease Relevance 0.21 Pain Relevance 0.72

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