INT904

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Context Info
Confidence 0.49
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 23
Total Number 25
Disease Relevance 7.98
Pain Relevance 5.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgfr) plasma membrane (Ptgfr) signal transducer activity (Ptgfr)
Anatomy Link Frequency
blood 2
uterine 2
myometrium 1
eye 1
nerves 1
Ptgfr (Mus musculus)
Pain Link Frequency Relevance Heat
allodynia 11 99.96 Very High Very High Very High
Dismenorea 21 99.64 Very High Very High Very High
Serotonin 6 99.52 Very High Very High Very High
COX-2 inhibitor 6 98.98 Very High Very High Very High
Pain 6 98.46 Very High Very High Very High
Angina 4 98.20 Very High Very High Very High
adenocard 9 97.84 Very High Very High Very High
Spinal cord 12 96.64 Very High Very High Very High
Trigeminal neuralgia 5 95.84 Very High Very High Very High
anticonvulsant 1 94.80 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 11 99.96 Very High Very High Very High
Hypertension 12 99.84 Very High Very High Very High
Bradycardia 2 99.80 Very High Very High Very High
Dysmenorrhea 12 99.64 Very High Very High Very High
Convulsion 10 99.60 Very High Very High Very High
Pressure Volume 2 Under Development 1 99.52 Very High Very High Very High
Myocardial Infarction 8 99.18 Very High Very High Very High
Targeted Disruption 12 99.08 Very High Very High Very High
Pressure And Volume Under Development 2 98.80 Very High Very High Very High
Pain 4 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The large tonic contractions also occurred in PGF(2alpha) receptor (FP) knockout mice in 19.0 G despite a small amount of OTR.
Positive_regulation (occurred) of PGF associated with targeted disruption
1) Confidence 0.49 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17148756 Disease Relevance 0.10 Pain Relevance 0.05
In summary, pre- or post-treatment with COX-2 inhibitors aggravates KA-induced seizures, which suggests to change the endogenous PGF(2alpha).
Positive_regulation (change) of PGF associated with convulsion and cox-2 inhibitor
2) Confidence 0.45 Published 2008 Journal Brain Res. Section Abstract Doc Link 18178179 Disease Relevance 0.70 Pain Relevance 0.39
Conversely, PGF(2 alpha)- and AMPA-induced allodynia were observed in GluR epsilon 1(-/-) mice, but not in GluR epsilon 4(-/-) mice.
Positive_regulation (induced) of PGF associated with allodynia
3) Confidence 0.30 Published 2001 Journal Brain Res. Section Abstract Doc Link 11259776 Disease Relevance 1.14 Pain Relevance 1.41
Baseline a-PGF2 alpha was elevated in EH patients with a sudden rise in blood pressure, and in MI patients without hypertension and unstable angina.
Positive_regulation (elevated) of a-PGF2 in blood associated with pressure and volume under development, angina, hypertension and myocardial infarction
4) Confidence 0.26 Published 1988 Journal Kardiologiia Section Abstract Doc Link 3164790 Disease Relevance 1.12 Pain Relevance 0.17
MI patients with bradyarrhythmias also had elevated a-PGF2 alpha levels.
Positive_regulation (elevated) of a-PGF2 associated with bradycardia and myocardial infarction
5) Confidence 0.26 Published 1988 Journal Kardiologiia Section Abstract Doc Link 3164790 Disease Relevance 1.10 Pain Relevance 0.19
Significant elevation of prostaglandin E (PGE) and F (PGF) levels in amniotic fluid was noted with the progress of cervical dilatation.
Positive_regulation (elevation) of PGF in amniotic fluid
6) Confidence 0.25 Published 1983 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 6873748 Disease Relevance 0 Pain Relevance 0.08
Using the FPEP2 cells as a model system, we showed that Butaprost stimulation of FPEP2 cells gave a robust intracellular accumulation of cAMP while PGF-mediated FP receptor activation by its own had no effect on cAMP production.
Positive_regulation (activation) of FP receptor
7) Confidence 0.08 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.04
Measurement of uterine activity and progesterone and total unconjugated oestrogen concentrations indicated that neither uterine contractions nor a decreased uterine blood flow accounted for the elevated PGF levels stimulated by oxytocin.
Positive_regulation (elevated) of PGF in uterine associated with dismenorea
8) Confidence 0.07 Published 1975 Journal Prostaglandins Section Abstract Doc Link 1135426 Disease Relevance 0.10 Pain Relevance 0.10
Pretreatment with anesthetic doses of pentobarbital supported increased accumulation of PGF2 alpha in postischemic cerebra, increased accumulation of 6-keto-PGF1 alpha during the ischemic episode, and decreased accumulation of PGE2 at 120 min of reperfusion.
Positive_regulation (accumulation) of PGF2
9) Confidence 0.06 Published 1988 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 3392120 Disease Relevance 0.31 Pain Relevance 0.24
Introduction of the EP2 receptor had no effect on the expression profile of the other E-series receptors and of FP receptor which could be activated by prostanoid ligands in our study.
Positive_regulation (activated) of FP receptor
10) Confidence 0.06 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.07 Pain Relevance 0.03
activation of the FP receptor via the calcium-calmodulin pathway
Positive_regulation (activation) of FP receptor
11) Confidence 0.06 Published 2010 Journal Cell Signal Section Title Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.16
In the puerperal animals oxytocin caused 3.7 - 17.2-fold increases in PGF concentrations with a marked latency in the response.
Positive_regulation (increases) of PGF
12) Confidence 0.05 Published 1975 Journal Prostaglandins Section Abstract Doc Link 1135426 Disease Relevance 0 Pain Relevance 0.09
However, as observed for the PGE2-mediated effects on second messenger production and intracellular signaling reported herein, the PGE2-mediated increase in COX-2 expression via the FP receptor is also less than that produced by the native ligand PGF2?.
Positive_regulation (increase) of FP receptor
13) Confidence 0.05 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.10
The mean time to onset of pain was shorter and more patients experienced blood loss over 100 ml during the induction in the PGF2 alpha group than in the gemeprost group (p less than 0.02).
Positive_regulation (induction) of PGF2 in blood associated with pain and pressure volume 2 under development
14) Confidence 0.05 Published 1989 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 2653893 Disease Relevance 0.36 Pain Relevance 0.10
In addition to elevated FP receptor, Ishikawa FPS cells also express basal levels of EP2 and EP4 receptor, but not detectable EP1 receptor (data not shown), which couple to Gs and mobilize intracellular cAMP.
Positive_regulation (elevated) of FP receptor
15) Confidence 0.04 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.20
activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element
Positive_regulation (activate) of FP receptor
16) Confidence 0.04 Published 2008 Journal Molecular and Cellular Endocrinology Section Title Doc Link PMC2694994 Disease Relevance 0.18 Pain Relevance 0
We conclude that: (i) continuous E2 infusion results in a pattern of uterine activity characterized by alternating high activity and quiescence, and increased frequency of occasional rises in basal IUP; (ii) E2 induced increases in OT and PGF2 alpha responses are consistent with other reports that E2 increases OT and PGF2 alpha binding to myometrium; (iii) the E2 effect on OT response is probably independent of enhanced PG synthesis.
Positive_regulation (increases) of PGF2 in myometrium associated with dismenorea
17) Confidence 0.02 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6311384 Disease Relevance 0.39 Pain Relevance 0.39
All 9 women with elevated PGF2 alpha-metabolite levels responded favourably to treatment of dysmenorrhea with prostaglandin synthetase inhibitors.
Positive_regulation (elevated) of PGF2 associated with dismenorea
18) Confidence 0.01 Published 1979 Journal Acta Obstet Gynecol Scand Suppl Section Abstract Doc Link 111466 Disease Relevance 0.25 Pain Relevance 0.25
Administration of Isop at 0.08 microgram.kg-1.min-1 produced no effects on uterine contractile activity but was associated with a significant elevation in plasma PGE2 (but not PGF2 alpha or PGFM) concentrations.
Positive_regulation (elevation) of PGF2 in uterine
19) Confidence 0.01 Published 1987 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2896537 Disease Relevance 0.13 Pain Relevance 0.23
Ibuprofen effectively suppressed endotoxin-induced increases in the plasma levels of TxB2, 6-keto-PGF1 alpha, PGF2 alpha, and serotonin and body temperature.
Positive_regulation (increases) of PGF2 in body associated with serotonin
20) Confidence 0.01 Published 1985 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 3867760 Disease Relevance 0.15 Pain Relevance 0.26

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