INT90402

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Context Info
Confidence 0.31
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.83
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
spinal 8
macrophage 2
aorta 2
epithelial cells 2
stomach 2
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 99 99.98 Very High Very High Very High
cINOD 25 97.92 Very High Very High Very High
Hyperalgesia 5 95.48 Very High Very High Very High
allodynia 2 94.80 High High
COX-2 inhibitor 7 93.92 High High
Analgesic 8 91.52 High High
alcohol 7 80.72 Quite High
withdrawal 7 79.44 Quite High
antagonist 1 77.40 Quite High
Thermal hyperalgesia 8 77.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 117 99.98 Very High Very High Very High
Hemophilus Infection 89 99.98 Very High Very High Very High
Injury 10 99.98 Very High Very High Very High
Abdominal Aortic Aneurysm 2 99.44 Very High Very High Very High
Lung Cancer 6 99.16 Very High Very High Very High
Stress 13 98.78 Very High Very High Very High
Malignant Neoplastic Disease 2 98.36 Very High Very High Very High
Nociception 4 97.48 Very High Very High Very High
Hyperalgesia 13 95.48 Very High Very High Very High
Pulmonary Disease 3 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase (COX) enzyme expression is elevated in human and rodent lung tumors, and non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin reduce lung tumor formation in mice.
Positive_regulation (elevated) of Gene_expression (expression) of Cyclooxygenase in lung associated with inflammation, lung cancer and cinod
1) Confidence 0.31 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12376474 Disease Relevance 0.58 Pain Relevance 0.35
Recent studies have shown that chronic ethanol administration up-regulates cyclooxygenase expression.
Positive_regulation (up-regulates) of Gene_expression (expression) of cyclooxygenase
2) Confidence 0.21 Published 2005 Journal Addict Biol Section Abstract Doc Link 16318954 Disease Relevance 0.08 Pain Relevance 0.25
Systemic inflammation leads to increased expression of spinal cyclooxygenase (COX)-2 and to a subsequent increase of prostaglandin (PG) biosynthesis, which contribute to the development of hyperalgesia and allodynia.
Positive_regulation (leads) of Gene_expression (expression) of cyclooxygenase in spinal associated with hyperalgesia, allodynia and inflammation
3) Confidence 0.09 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.29 Pain Relevance 0.28
The aqueous extract of corni fructus suppressed PGE(2) synthesis and NO production by inhibiting the lipopolysaccharide-induced expression of cyclooxygenase (COX)-2 and inducible NO synthase (iNOS) in murine RAW 264.7 macrophage cells.
Positive_regulation (induced) of Gene_expression (expression) of cyclooxygenase in macrophage
4) Confidence 0.08 Published 2009 Journal J Med Food Section Abstract Doc Link 19735178 Disease Relevance 0.30 Pain Relevance 0.55
Taken together, these results provide evidence for cholinergic regulation of transepithelial transport of macromolecules, mainly mediated by activation of M3 receptors with subsequent involvement of phospholipase A(2) and cyclooxygenase products.
Positive_regulation (involvement) of Gene_expression (products) of cyclooxygenase
5) Confidence 0.07 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17187588 Disease Relevance 0 Pain Relevance 0.14
It is widely accepted that peripheral injury increases spinal inducible cyclooxygenase (COX-2) expression and prostaglandin E(2) (PGE(2)) formation as key mediators of nociceptive sensitization.
Positive_regulation (inducible) of Gene_expression (expression) of cyclooxygenase in spinal associated with nociception and injury
6) Confidence 0.06 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10964977 Disease Relevance 0.49 Pain Relevance 0.22
It is widely accepted that peripheral injury increases spinal inducible cyclooxygenase (COX-2) expression and prostaglandin E(2) (PGE(2)) formation as key mediators of nociceptive sensitization.
Positive_regulation (increases) of Gene_expression (expression) of cyclooxygenase in spinal associated with nociception and injury
7) Confidence 0.06 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10964977 Disease Relevance 0.49 Pain Relevance 0.22
Systemic inflammation leads to increased expression of spinal cyclooxygenase (COX)-2 and to a subsequent increase of prostaglandin (PG) biosynthesis, which contribute to the development of hyperalgesia and allodynia.
Positive_regulation (increased) of Gene_expression (expression) of cyclooxygenase in spinal associated with hyperalgesia, allodynia and inflammation
8) Confidence 0.06 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.29 Pain Relevance 0.28
PK (20 mg/kg, p. o. × 3 days) could effectively heal indomethacin-induced stomach ulceration in mice by reducing oxidative stress, and promoting mucin secretion, prostaglandin synthesis and augmenting expressions of cyclooxygenase enzymes and growth factors.



Positive_regulation (augmenting) of Gene_expression (expressions) of cyclooxygenase in stomach associated with stress
9) Confidence 0.06 Published 2008 Journal BMC Complement Altern Med Section Abstract Doc Link PMC2266895 Disease Relevance 0.16 Pain Relevance 0
OBJECTIVE: Inflammation plays an integral role in the development of abdominal aortic aneurysms (AAAs), and the expression of cyclooxygenase (COX)-2 is increased in aneurysmal tissue compared with normal aorta.
Positive_regulation (increased) of Gene_expression (expression) of cyclooxygenase in aorta associated with inflammation and abdominal aortic aneurysm
10) Confidence 0.04 Published 2006 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 16514081 Disease Relevance 0.37 Pain Relevance 0.18
This increased prostaglandin E2 is due to enhanced expression of inducible cyclooxygenase [80].
Positive_regulation (enhanced) of Gene_expression (expression) of cyclooxygenase
11) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.40 Pain Relevance 0.26
As it was postulated before, the inducible cyclooxygenase isoenzyme, COX-2, is significantly overexpressed at sites of inflammation and in various malignant tissues, with concomitant overproduction of the major arachidonate metabolite, PGE2 [43].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of cyclooxygenase isoenzyme associated with malignant neoplastic disease and inflammation
12) Confidence 0.02 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3004002 Disease Relevance 0.84 Pain Relevance 0.17
Herein, we tested that the hypothesis that NTHi induces the expression of cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) via activation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappa B in pulmonary alveolar epithelial cells.


Positive_regulation (induces) of Gene_expression (expression) of cyclooxygenase in epithelial cells associated with hemophilus infection
13) Confidence 0.01 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2270828 Disease Relevance 0.53 Pain Relevance 0

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