INT90406

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Context Info
Confidence 0.38
First Reported 2000
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 15.74
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6R) extracellular region (IL6R) plasma membrane (IL6R)
enzyme binding (IL6R)
Anatomy Link Frequency
plasma 2
adipose tissue 2
blood 1
hip 1
skin 1
IL6R (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 100.00 Very High Very High Very High
agonist 51 99.40 Very High Very High Very High
Inflammatory marker 5 98.06 Very High Very High Very High
withdrawal 6 97.08 Very High Very High Very High
Pain 17 97.00 Very High Very High Very High
metalloproteinase 18 93.60 High High
Inflammation 317 92.56 High High
cytokine 280 90.80 High High
rheumatoid arthritis 364 90.16 High High
methotrexate 221 80.88 Quite High
Disease Link Frequency Relevance Heat
Overweight 158 99.46 Very High Very High Very High
Obesity 169 99.14 Very High Very High Very High
Keloid Scars 310 98.72 Very High Very High Very High
Intervertebral Disk Displacement 4 98.68 Very High Very High Very High
Coronary Artery Disease 26 98.66 Very High Very High Very High
INFLAMMATION 361 97.90 Very High Very High Very High
Disease 257 97.84 Very High Very High Very High
Pain 11 97.00 Very High Very High Very High
Carcinoma 33 96.84 Very High Very High Very High
Repression 5 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other inflammatory markers that were expressed at higher level in adipose tissue from overweight subjects included leptin, complement factor D (CFD), interleukin receptor 6 (IL6R), interleukin receptor 10 alpha (IL10RA), interleukin 1 receptor antagonist (IL1RN) and a number of interleukins (IL15, IL17D, IL18) (data not shown).
Gene_expression (antagonist) of IL6R in adipose tissue associated with antagonist, inflammatory marker, obesity and overweight
1) Confidence 0.38 Published 2008 Journal Genes Nutr Section Body Doc Link PMC2593008 Disease Relevance 1.48 Pain Relevance 0.13
Other inflammatory markers that were expressed at higher level in adipose tissue from overweight subjects included leptin, complement factor D (CFD), interleukin receptor 6 (IL6R), interleukin receptor 10 alpha (IL10RA), interleukin 1 receptor antagonist (IL1RN) and a number of interleukins (IL15, IL17D, IL18) (data not shown).
Gene_expression (complement) of IL6R in adipose tissue associated with antagonist, inflammatory marker, obesity and overweight
2) Confidence 0.38 Published 2008 Journal Genes Nutr Section Body Doc Link PMC2593008 Disease Relevance 1.64 Pain Relevance 0.13
The presence of soluble IL-6R allows cell activation through gp130, a process known as trans-signaling, in tissues that do not constitutively express IL-6R (Rose-John 2003).
Neg (not) Gene_expression (express) of IL-6R
3) Confidence 0.11 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.49 Pain Relevance 0.18
IL-6R is expressed on several cell types.
Gene_expression (expressed) of IL-6R
4) Confidence 0.11 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.51 Pain Relevance 0.19
The presence of soluble IL-6R allows cell activation through gp130, a process known as trans-signaling, in tissues that do not constitutively express IL-6R (Rose-John 2003).
Gene_expression (presence) of IL-6R
5) Confidence 0.09 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.43 Pain Relevance 0.17
Tocilizumab humanized anti-interleukin-6 receptor antibody
Gene_expression (antibody) of anti-interleukin-6 receptor
6) Confidence 0.09 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638601 Disease Relevance 0.36 Pain Relevance 0.29
Interestingly, the same treatment reduced he expression of IL-6R in normal cells resulting in a response pattern as found in the corresponding carcinoma cells from the same patient (Fig. 6).


Gene_expression (expression) of IL-6R associated with carcinoma
7) Confidence 0.05 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.48 Pain Relevance 0.03
Possible mechanisms are genetic and epigenetic changes [1,28] that lead to the inactivation of receptor genes such as silencing LIFR by DNA methylation [29] or enhanced expression of LIFR, OSMR, but reduced expression of IL-6R by acetylation of histone and transcription-controlling factors [22].
Gene_expression (expression) of IL-6R
8) Confidence 0.05 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0 Pain Relevance 0.12
In contrast, sIL-6R could not be detected in cells treated with or without IL-1 beta.
Neg (not) Gene_expression (detected) of sIL-6R
9) Confidence 0.05 Published 2002 Journal J. Oral Pathol. Med. Section Body Doc Link 12190816 Disease Relevance 0.07 Pain Relevance 0
These results demonstrated the production of factors such as TGF-beta1, IGF-1, IL-6, IL-6R and fibronectin at the site of lumbar disc herniation.
Gene_expression (production) of IL-6R
10) Confidence 0.04 Published 2002 Journal Eur Spine J Section Abstract Doc Link 11956921 Disease Relevance 0.25 Pain Relevance 0.11
After forming a complex with IL-6, soluble (s) IL-6R can also combine with gp130 on the cell membrane and enables signaling (Ward et al 1994). s IL-6R is present in the blood of healthy individuals at a concentration of several tens of ng/mL, and if the cells express gp130, IL-6 signaling can take place, even in the absence of IL-6R expression on the cell membrane.
Gene_expression (expression) of IL-6R in blood
11) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.28 Pain Relevance 0.13
In this study we used immunohistochemistry to investigate the presence of transforming growth factor-beta1 (TGF-beta1), insulin-like growth factor-1 (IGF-1), interleukin-6 (IL-6), IL-6-receptor (IL-6R) and fibronectin in lumbar disc bioptic specimens from 30 patients with disc herniation (protrusion type).
Spec (investigate) Gene_expression (presence) of IL-6R
12) Confidence 0.04 Published 2002 Journal Eur Spine J Section Abstract Doc Link 11956921 Disease Relevance 0.25 Pain Relevance 0.13
In cells expressing IL-6R on their cell surface, IL-6 binds to mIL-6R, and by associating with the gp130 protein transmits a signal into the cells.
Gene_expression (expressing) of IL-6R
13) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857613 Disease Relevance 0.69 Pain Relevance 0.11
Tocilizumab inhibits the induction of biological activity due to IL-6 in cells that have expressed both membrane-bound IL-6R and gp130 molecules, and also inhibits the induction of biological activity due to IL-6/IL-6R complex formation in cells that express gp130 alone.
Gene_expression (expressed) of IL-6R
14) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.24 Pain Relevance 0.08
Decreased expression of angiogenic proteins such as IL-6R, ADAM family genes, CD44, IL-8, Rho family genes, integrin-?
Gene_expression (expression) of IL-6R
15) Confidence 0.03 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.48 Pain Relevance 0.11
Both IL-6 and IL-6R were expressed in SKPs and KPCs, with a relatively higher level in KPCs as compared to the matched SKPs, as determined by Western blot, RT-PCR and flow cytometry (Figures 3G and 3H; Figure S4C).
Gene_expression (expressed) of IL-6R
16) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.84 Pain Relevance 0.26
Consistent with previous reports [5], [6], we have demonstrated that IL-6 is significantly up-regulated in keloid scars versus their normal skin counterparts, and KPCs constitutively express a higher level of IL-6 and IL-6R compared to SKPs.
Gene_expression (express) of IL-6R in skin associated with keloid scars
17) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 1.47 Pain Relevance 0.31
Since KPCs constitutively expressed a higher level of IL-6 and IL-6R than SKPs (Figures 3G and 3H; Figure S4C), we next tested whether the intrinsically secreted IL-6 might contribute to the elevated telomerase expression and activity in KPCs.
Gene_expression (expressed) of IL-6R
18) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.28 Pain Relevance 0.03
Serum levels of sIL-6R, acting as an agonist to IL-6, were suppressed significantly in the HRT group after 12 and 24 months.
Gene_expression (levels) of sIL-6R associated with agonist
19) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0 Pain Relevance 0.13
Levels of serum MRA, IL-6, sIL-6R and anti-MRA antibodies were screened during the follow up period by contract laboratories of the sponsor.
Gene_expression (Levels) of sIL-6R
20) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297576 Disease Relevance 0.88 Pain Relevance 0.03

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