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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.77
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100A8) extracellular region (S100A8) plasma membrane (S100A8)
cytoskeleton (S100A8) cytoplasm (S100A8)
Anatomy Link Frequency
upper 1
S100A8 (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 8 91.00 High High
Inflammation 4 75.00 Quite High
medulla 1 51.32 Quite High
ischemia 4 49.52 Quite Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastritis 6 100.00 Very High Very High Very High
Gastrointestinal Disease 2 97.68 Very High Very High Very High
Prostate Cancer 55 93.60 High High
Duodenal Ulcer 1 91.64 High High
Cancer 36 91.24 High High
Ulcers 8 91.00 High High
Disease 14 90.48 High High
Stomach Cancer 2 89.72 High High
Adenocarcinoma 1 78.40 Quite High
Metastasis 51 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In H. pylori, disruption of the virulence factors vacA, cagA, and cagE did not alter adherence, but deletion of DAF complement control protein (CCP) domains 1-4 or the heavily O-glycosylated serine-threonine-rich COOH-terminal domain reduced binding.
Negative_regulation (disruption) of cagA
1) Confidence 0.57 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16543227 Disease Relevance 0.60 Pain Relevance 0.15
Of the Malay, Chinese and Indian patients, 76.6%, 86.4% and 86.8%, respectively, were cagA positive, and 70.0%, 39.0% and 81.6%, respectively, were cagE positve.
Negative_regulation (positive) of cagA
2) Confidence 0.42 Published 2005 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 15836708 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Most H. pylori strains found in patients with PUD possess the vacA s1 genotype and the cagA gene.
Negative_regulation (possess) of cagA
3) Confidence 0.41 Published 2000 Journal Z Gastroenterol Section Body Doc Link 10965552 Disease Relevance 0.06 Pain Relevance 0
Prevalence of Helicobacter pylori cagA, iceA and babA2 alleles in Brazilian patients with upper gastrointestinal diseases.
Negative_regulation (Prevalence) of cagA in upper associated with gastrointestinal disease and gastritis
4) Confidence 0.41 Published 2006 Journal Acta Trop. Section Title Doc Link 17181989 Disease Relevance 1.10 Pain Relevance 0.09
Our analysis has also identified a number of additional genes, such as KLK11,STC1 and S100A8 that are uniformly regulated in all metastatic patients.
Negative_regulation (number) of S100A8
5) Confidence 0.33 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.01 Pain Relevance 0.03

General Comments

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