INT90461

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Context Info
Confidence 0.53
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 8.35
Pain Relevance 6.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (DRD2) plasma membrane (DRD2) signal transducer activity (DRD2)
Anatomy Link Frequency
striatum 3
basal ganglia 2
SH-SY5Y 1
brains 1
DRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 1149 100.00 Very High Very High Very High
dopamine receptor 68 100.00 Very High Very High Very High
antagonist 49 100.00 Very High Very High Very High
positron emission tomography 389 99.96 Very High Very High Very High
Serotonin 128 99.80 Very High Very High Very High
Cannabinoid 23 99.68 Very High Very High Very High
imagery 197 99.22 Very High Very High Very High
mu opioid receptor 8 95.80 Very High Very High Very High
agonist 148 95.36 Very High Very High Very High
Nicotine 201 94.16 High High
Disease Link Frequency Relevance Heat
Disease 576 99.56 Very High Very High Very High
Parkinsonian Disorders 312 99.04 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 726 99.00 Very High Very High Very High
Neuroblastoma 4 99.00 Very High Very High Very High
Congenital Anomalies 131 98.70 Very High Very High Very High
Liver Disease 96 98.26 Very High Very High Very High
Hypersensitivity 5 95.00 High High
Nicotine Addiction 353 94.16 High High
Coronary Artery Disease 1 94.00 High High
Toxicity 11 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A decrease in D2R levels measured by PET also has been noted in another case report (Kessler et al. 2003) (Table 2).
Negative_regulation (decrease) of D2R associated with positron emission tomography
1) Confidence 0.53 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.93 Pain Relevance 0.46
In general, these occupationally exposed workers with Mn-induced movement abnormalities had normal [18F]-fluoro-dopa PET, normal DAT SPECT, and a small decrease in D2R PET.
Negative_regulation (decrease) of D2R associated with congenital anomalies and positron emission tomography
2) Confidence 0.53 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.92 Pain Relevance 0.46
Positron emission tomography with C-11 raclopride revealed a mild decrease in the dopamine D 2 receptor numbers in the bilateral striatum.
Negative_regulation (decrease) of dopamine D 2 receptor in striatum associated with dopamine and positron emission tomography
3) Confidence 0.51 Published 2000 Journal Rinsho Shinkeigaku Section Abstract Doc Link 10967655 Disease Relevance 0.75 Pain Relevance 0.41
This was accompanied by a decrease in the level of D2 receptor messenger RNA in the striatum as measured by northern blotting.
Negative_regulation (decrease) of D2 receptor in striatum
4) Confidence 0.42 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.50 Pain Relevance 0.37
Taken together, these results suggest that the down-regulation of D2 dopamine receptor and D2 receptor messenger RNA is the result of the persistent stimulation of D2 receptors and that the up-regulation of mu opioid receptors may be a compensatory response to a decreased biosynthesis of enkephalin.
Negative_regulation (regulation) of D2 receptor associated with dopamine receptor, mu opioid receptor and enkephalin
5) Confidence 0.42 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.12 Pain Relevance 0.53
There was a main effect of DRD2 TaqI A genotype (F (1,164) = 7.65, p = .006, ?
Negative_regulation (effect) of DRD2 TaqI
6) Confidence 0.41 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.45 Pain Relevance 0
These results were opposite to what Eriksson et al. (1992b) and Guilarte et al. (2008) reported with in vivo PET imaging and in vitro autoradiography¬óthat is, decreased D2R and no effect on D1R.
Negative_regulation (decreased) of D2R associated with positron emission tomography and imagery
7) Confidence 0.39 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.15 Pain Relevance 0.37
Neurochemical studies of the brains of patients with liver disease have confirmed for the most part the results from neuroimaging studies: a significant decrease in D2R levels in the basal ganglia and no observed decrease in dopamine levels (Table 1).
Negative_regulation (decrease) of D2R in brains associated with liver disease and dopamine
8) Confidence 0.39 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.35 Pain Relevance 0.23
Further, in Mn-induced parkinsonism, Huang (2007) observed small but significantly decreased D2R signals, which is the opposite of what is observed in PD.
Negative_regulation (decreased) of D2R associated with disease and parkinsonian disorders
9) Confidence 0.39 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.88 Pain Relevance 0.44
The effect of Mn on in vivo dopamine release was observed in the absence of a change in DAT levels and with a small but significant decrease on D2R levels in the striatum (Guilarte et al. 2008).
Negative_regulation (decrease) of D2R in striatum associated with dopamine
10) Confidence 0.39 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.16 Pain Relevance 0.69
Consistent evidence has shown that D2R levels are decreased, and one study indicated no change in D1R.
Negative_regulation (decreased) of D2R
11) Confidence 0.39 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.27 Pain Relevance 0.27
In one study, Mousseau et al. (1993) used in vitro autoradiography and found decreased D2R levels in the globus pallidus and putamen with no change in D1-dopamine receptors (D1Rs) in the basal ganglia of patients with liver disease (Table 3).
Negative_regulation (decreased) of D2R in basal ganglia associated with liver disease and dopamine receptor
12) Confidence 0.39 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.29 Pain Relevance 0.28
Specific RNA changes in htt171-82Q-expressing striatal cells accurately recapitulated those observed in human HD caudate and included decreases in PENK (proenkephalin), RGS4 (regulator of G-protein signaling 4), dopamine D(1) receptor (DRD1), DRD2, CNR1 (cannabinoid CB(1) receptor), and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein-32; also known as PPP1R1B) mRNAs.
Negative_regulation (decreases) of DRD2 associated with dopamine, cannabinoid and disease
13) Confidence 0.35 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18815258 Disease Relevance 0.84 Pain Relevance 0.15
The hypothesis that people with altered transport or a reduced D2 receptor density have a deficit in their reward system and feel an enhanced reward when exposed to dopaminergic agents, thereby making them more prone to nicotine addiction, has been supported by epidemiologic studies (Table 2) [27,85,86,98-105].
Negative_regulation (reduced) of D2 receptor associated with addiction and nicotine
14) Confidence 0.17 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.16 Pain Relevance 0.30
The hypothesis that people with altered transport or a reduced D2 receptor density have a deficit in their reward system and feel an enhanced reward when exposed to dopaminergic agents, thereby making them more prone to nicotine addiction, has been supported by epidemiologic studies (Table 2) [27,85,86,98-105].
Negative_regulation (reduced) of D2 receptor associated with addiction and nicotine
15) Confidence 0.17 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.16 Pain Relevance 0.30
In a different PET study, Farde et al (1997) observed a significant decrease in dopamine D2 receptor density in individuals with detachment, social isolation, and lack of intimate friendships.


Negative_regulation (decrease) of dopamine D2 receptor associated with dopamine and positron emission tomography
16) Confidence 0.14 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0 Pain Relevance 0.26
Noble and Blum and associates had previously shown that Taq I D2A1 carriers had a significantly decreased dopamine D2 receptor in the basal ganglia.
Negative_regulation (decreased) of dopamine D2 receptor in basal ganglia associated with dopamine
17) Confidence 0.10 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0 Pain Relevance 0.29
Although typical neuroleptics act via dopamine-D2 receptor blockade, they all (including haloperidol) affect both dopaminergic and serotonergic receptors [5].
Negative_regulation (blockade) of dopamine-D2 receptor associated with dopamine
18) Confidence 0.09 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1888684 Disease Relevance 0.45 Pain Relevance 0.34
In SH-SY5Y neuroblastoma cells co-stimulation of A2AR and D2R accelerated D2R desensitization, probably by causing or enhancing D2R internalization [78].
Negative_regulation (desensitization) of D2R in SH-SY5Y associated with neuroblastoma
19) Confidence 0.05 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.38 Pain Relevance 0.15
Itopride is a dopamine D2 antagonist with acetylcholinesterase inhibitory activity that has prokinetic effects and probably effects on gastric accommodation and hypersensitivity (Longstreth, 2010).
Negative_regulation (antagonist) of dopamine D2 associated with dopamine, antagonist and hypersensitivity
20) Confidence 0.03 Published 2010 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2984130 Disease Relevance 0.10 Pain Relevance 0.10

General Comments

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