INT90491

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 9.75
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
smooth muscle cells 2
blood 1
neuronal 1
plasma 1
nucleus 1
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 16 98.76 Very High Very High Very High
anesthesia 17 98.44 Very High Very High Very High
Bioavailability 5 97.60 Very High Very High Very High
Somatostatin 128 87.00 High High
Demyelination 27 86.88 High High
cytokine 46 86.80 High High
dorsal root ganglion 1 83.80 Quite High
ischemia 45 80.68 Quite High
Hippocampus 31 76.08 Quite High
cerebral cortex 24 75.28 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 482 99.80 Very High Very High Very High
Hypoglycemia 20 99.44 Very High Very High Very High
Retinal Neovascularization 7 99.12 Very High Very High Very High
Diabetes Mellitus 101 98.80 Very High Very High Very High
Hyperinsulinism 17 98.36 Very High Very High Very High
Toxicity 37 98.08 Very High Very High Very High
Stress 228 97.06 Very High Very High Very High
Targeted Disruption 169 96.84 Very High Very High Very High
Aging 184 96.10 Very High Very High Very High
Lifespan 130 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among IGFBPs, IGFBP-3 is very important since it binds more than 95% of IGF-I in blood circulation.[22]
IGF-I Binding (binds) of in blood
1) Confidence 0.44 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.20 Pain Relevance 0.05
The actions of Igf1 depend largely on its binding to extracellular proteins such as Igfbp2 and Igfbp3 [29-31].
Igf1 Binding (binding) of
2) Confidence 0.40 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.55 Pain Relevance 0.13
Last but not least, IGF1 plasma levels decline with age in humans and rodents [52–54].
IGF1 Binding (decline) of in plasma
3) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 0.91 Pain Relevance 0
-ATGGGCTTCCCGTTGATGA); Igf1-F (5?
Igf1 Binding (ATGGGCTTCCCGTTGATGA) of
4) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0 Pain Relevance 0
From the data presented above and despite limitations in design, it would appear that lanreotide Autogel® and octreotide LAR are equipotent in normalizing GH and IGF-I concentrations.
IGF-I Binding (normalizing) of
5) Confidence 0.35 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0 Pain Relevance 0.04
In some but not all studies normal IGF-I was also associated with improved mortality (Ayuk et al 2004; Biermasz et al 2004a; Holdaway et al 2004; Kauppinen et al 2005).
IGF-I Binding (associated) of
6) Confidence 0.35 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.46 Pain Relevance 0.08
Results indicated that in cultures supplemented (48 h) with either TGF-beta, TGF-beta + IGF-1 or with GH, an increased height and area of TB-positive staining as well as increased incorporation of (35)S-SO(4) into sulfated PG were observed.
IGF-1 Binding (supplemented) of
7) Confidence 0.34 Published 2000 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 10971036 Disease Relevance 0.20 Pain Relevance 0.18
In this regard, a polymorphism in the promoter region of the IGF-I gene was associated with low levels of IGF-I and increased risk of type-2 diabetes mellitus.[21] In addition to this, IGF-I binding proteins (IGFBPs) were not measured, which play an important role in regulating the bioavailability of IGF-I.
IGF-I Binding (associated) of associated with diabetes mellitus and bioavailability
8) Confidence 0.34 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.33 Pain Relevance 0.05
An interaction between VEGF and IGF-1 was characterized in retinal neovascularization in diabetic patients [37].
IGF-1 Binding (interaction) of associated with diabetes mellitus and retinal neovascularization
9) Confidence 0.34 Published 2003 Journal Crit Care Section Body Doc Link PMC374373 Disease Relevance 0.57 Pain Relevance 0.17
IGF-1, IGF-1 binding protein 3 (IGF-BP3, also known as GH-dependent binding protein), and acid-labile subunit (ALS) form a ternary complex in the serum and are all reduced in GH insensitivity disorders in proportion to the severity of GH resistance [38].
IGF-1 Binding (binding) of
10) Confidence 0.33 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.52 Pain Relevance 0
IGF-1, IGF-1 binding protein 3 (IGF-BP3, also known as GH-dependent binding protein), and acid-labile subunit (ALS) form a ternary complex in the serum and are all reduced in GH insensitivity disorders in proportion to the severity of GH resistance [38].
IGF-1 Binding (binding) of
11) Confidence 0.33 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.52 Pain Relevance 0
Mice with extended lifespans that do not exhibit a direct link to GH/IGF-1/insulin signaling are far fewer in number.
IGF-1 Neg (not) Binding (link) of
12) Confidence 0.32 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.84 Pain Relevance 0.03
Treatments with IGF-1 and Pharmacological Inhibitors
IGF-1 Binding (Treatments) of
13) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.19 Pain Relevance 0
Untreated cells (Fig. 4A) contained both nuclear and cytoplasmic ASF/SF2, whereas after treatment with IGF-1, ASF/SF2 localized specifically to the nucleus (Fig. 4B).
IGF-1 Binding (treatment) of in nucleus
14) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
Mean litter size was calculated from matings between bIGF1RKO+/?
bIGF1RKO Binding (matings) of
15) Confidence 0.23 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.24 Pain Relevance 0.10
This may apply to bIGF1RKO+/?
bIGF1RKO Binding (apply) of
16) Confidence 0.23 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.59 Pain Relevance 0
Recombinant human IGF-I (Chiron Corp., Emeryville, CA, USA) was used as radioligand and unlabeled ligand.
IGF-I Binding (radioligand) of
17) Confidence 0.19 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.14 Pain Relevance 0.06
The receptor for IGF1 is structurally similar to the insulin receptor; both are tyrosine kinases that phosphorylate similar insulin receptor substrate proteins [72].
IGF1 Binding (receptor) of
18) Confidence 0.18 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.33 Pain Relevance 0.10
Insulin-like growth factor-1, through its binding to the insulin-like growth factor-1 receptor, is known to play a vital role in oligodendrocyte development, survival and myelination (McMorris et al., 1986).
Insulin-like growth factor-1 Binding (binding) of in oligodendrocyte
19) Confidence 0.18 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.45 Pain Relevance 0.15
Serum concentrations of IGF-II, IGF-I and IGFBP-2 were determined by radioimmunoassays (RIAs), which were standardized in the hormone laboratory of the Children's Hospital, University of Tübingen as previously described [24].


IGF-I Binding (concentrations) of
20) Confidence 0.18 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.25 Pain Relevance 0.09

General Comments

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