INT90496

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.44
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Dnmt1) nucleus (Dnmt1) DNA binding (Dnmt1)
protein complex (Dnmt1) transcription factor binding (Dnmt1) cytoplasm (Dnmt1)
Anatomy Link Frequency
colon 1
tails 1
muscle 1
lung 1
heart 1
Dnmt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Root ganglion neuron 1 98.88 Very High Very High Very High
Nicotine 2 98.82 Very High Very High Very High
tetrodotoxin 1 97.48 Very High Very High Very High
sodium channel 4 91.36 High High
Peripheral nervous system 1 82.64 Quite High
gABA 13 82.20 Quite High
agonist 1 81.88 Quite High
antidepressant 3 79.04 Quite High
Hippocampus 18 77.00 Quite High
addiction 18 76.88 Quite High
Disease Link Frequency Relevance Heat
Aging 83 99.18 Very High Very High Very High
Ganglion Cysts 1 98.72 Very High Very High Very High
Schizophrenia 17 98.34 Very High Very High Very High
Nicotine Addiction 171 97.58 Very High Very High Very High
Urological Neuroanatomy 11 97.20 Very High Very High Very High
Fatigue 7 97.12 Very High Very High Very High
Thrombocytopenia 15 96.60 Very High Very High Very High
Colon Cancer 11 96.16 Very High Very High Very High
Cancer 292 94.28 High High
Solid Tumor 44 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This agent has shown an ability to inhibit DNMT1 gene expression without affecting other DNMTs and to cause demethylation with p16 re-expression in bladder and colon cancer cell lines, as well as to produce tumor growth inhibition in nude mice bearing human lung and colon xenografts [57].
Gene_expression (expression) of DNMT1 in colon associated with cancer and colon cancer
1) Confidence 0.60 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 1.07 Pain Relevance 0
MG98's molecular efficacy was demonstrated by producing a DNMT mRNA level decrease in the peripheral blood cells in six of 10 patients [58].
Gene_expression (producing) of DNMT in blood cells
2) Confidence 0.41 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.84 Pain Relevance 0
In addition, both DNMT1 and methyl-binding proteins (MBP), such as methyl-CpG-binding protein 2 (MeCP2) recruit histone deacetylases which deacetilate histone core tails leading to tighter chromatin packaging, reducing the access of transcriptional factors to DNA [11,12].
Gene_expression (deacetylases) of DNMT1 in tails
3) Confidence 0.40 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1131894 Disease Relevance 0.20 Pain Relevance 0
Although the expression of DNMT1 and DNMT3a showed some tissue and regional differences, we did not observe major aging-associated alterations in the mRNA levels of these two enzymes, with the only exception that there was lower DNMT3a mRNA content in the heart of old mice.
Gene_expression (expression) of DNMT1 in heart associated with aging
4) Confidence 0.40 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.49 Pain Relevance 0.04
Senescence has been associated with alterations in DNMT activity [41] and expression [28].
Gene_expression (expression) of DNMT associated with aging
5) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.49 Pain Relevance 0.04
This agent has shown an ability to inhibit DNMT1 gene expression without affecting other DNMTs and to cause demethylation with p16 re-expression in bladder and colon cancer cell lines, as well as to produce tumor growth inhibition in nude mice bearing human lung and colon xenografts [57].
Gene_expression (expression) of DNMT1 in lung associated with cancer and colon cancer
6) Confidence 0.20 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 1.07 Pain Relevance 0
In addition, it has been shown that valproic acid downregulates expression of proteins essential for chromatin maintenance: SMCs 1-6 (Structural Maintenance of chromatin 1 to 6), DNMT1 (DNA methyl transferase-1), and HP1 (Heterochromatin Protein-1) [25].
Gene_expression (expression) of DNMT1
7) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.08 Pain Relevance 0
Hypermethylation of the promoter, usually corresponding to inhibition of gene expression, is controlled by DNA methytransferase (DNMT).
Gene_expression (methytransferase) of DNMT
8) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.07 Pain Relevance 0
More specifically, keeping in mind that smoking is frequently abused by schizophrenia patients [49], nicotine (injected sub-cutaneously) was recently found to decrease DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in the mouse frontal cortex [50].
Gene_expression (expression) of DNA methyltransferase 1 in frontal cortex associated with nicotine addiction, nicotine, urological neuroanatomy and schizophrenia
9) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.88 Pain Relevance 0.24
In the periphery, both toxins inhibit tetrodotoxin-sensitive sodium current inactivation in dorsal root ganglion neurons, and are strongly active directly on the muscle and on expressed muI channels.
Gene_expression (expressed) of muI in muscle associated with ganglion cysts, tetrodotoxin and root ganglion neuron
10) Confidence 0.00 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10971624 Disease Relevance 0.25 Pain Relevance 0.39

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