INT90528

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.25
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
viscera 2
brain 2
LEK 2
dorsal horn 2
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 79 98.28 Very High Very High Very High
Dorsal horn 4 95.80 Very High Very High Very High
antagonist 2 95.44 Very High Very High Very High
withdrawal 2 94.84 High High
agonist 2 94.84 High High
orphanin 4 91.32 High High
Spinal cord 47 89.08 High High
Intracerebroventricular 1 84.40 Quite High
Opioid 2 83.40 Quite High
narcan 1 78.56 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 1 75.00 Quite High
Pain 4 64.12 Quite High
Pressure And Volume Under Development 4 58.08 Quite High
Ganglion Cysts 4 34.28 Quite Low
Nociception 5 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Ulcers 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also evaluated c-Fos immunoreactivity in those areas of the brain which have been shown to exhibit altered c-Fos expression upon N/OFQ administration.
Negative_regulation (evaluated) of c-Fos Binding (immunoreactivity) of in brain
1) Confidence 0.41 Published 2000 Journal Brain Res. Section Abstract Doc Link 10973597 Disease Relevance 0 Pain Relevance 0.57
Since laminae III and IV do not seem to receive direct input from the viscera [17,32], we hypothesize that the reduction of c-fos mRNA formation in these laminae is an indirect effect of capsaicin.
Negative_regulation (reduction) of c-fos mRNA Binding (formation) of in viscera associated with qutenza
2) Confidence 0.40 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0.11 Pain Relevance 0.55
Pretreatment with the c-fos antisense ODN significantly decreased the CFA-induced expression of c-Fos protein dose-dependently in ipsilateral laminae I/II (LI/II) of the dorsal horn (mean +/- SEM per section: 10 nM ODN, 43.9+/-1.3; 25 nM ODN, 19.4+/-4.1) compared with pretreatment with the mismatch ODN (63.6+/-2.9; 60.6+/-4.0) or saline (56.6+/-5.5).
Negative_regulation (decreased) of c-fos antisense ODN Binding (Pretreatment) of in dorsal horn associated with dorsal horn
3) Confidence 0.35 Published 2001 Journal Exp Brain Res Section Abstract Doc Link 11521152 Disease Relevance 0.07 Pain Relevance 0.24
RESULTS: Compared with group A, the pain score, systolic pressure, the activity of AChE, the content of SP, and the positive index of c-Fos protein and GFAP of group B increased significantly (all P < 0.05); compared with group B, the pain score, AChE activity, the content of SP and the positive index of c-Fos protein and GFAP of both group C and group D decreased significantly (all P < 0.05); compared with group B, the content of LEK increased and systolic pressure decreased significantly in group C (both P < 0.05).
Negative_regulation (positive) of c-Fos protein Binding (index) of in LEK
4) Confidence 0.11 Published 2010 Journal Zhongguo Zhen Jiu Section Body Doc Link 20886795 Disease Relevance 0.06 Pain Relevance 0

General Comments

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