INT90566

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.46
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
retina 2
neurons 2
Gad1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 15 100.00 Very High Very High Very High
narcan 2 100.00 Very High Very High Very High
Dopamine 5 98.80 Very High Very High Very High
Enkephalin 3 98.66 Very High Very High Very High
Central grey 6 98.52 Very High Very High Very High
substance P 2 98.36 Very High Very High Very High
GABAergic 22 97.60 Very High Very High Very High
Opioid 6 97.44 Very High Very High Very High
withdrawal 7 97.16 Very High Very High Very High
Hippocampus 1 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 55 99.12 Very High Very High Very High
Urological Neuroanatomy 6 98.52 Very High Very High Very High
Opiate Addiction 5 97.44 Very High Very High Very High
Aids-related Complex 1 89.72 High High
Ganglion Cysts 64 70.20 Quite High
Disease 1 68.08 Quite High
Parkinson's Disease 1 62.00 Quite High
Attention Deficit Hyperactivity Disorder 1 42.96 Quite Low
Umbilical Hernia 24 5.00 Very Low Very Low Very Low
Cleft Palate 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The generation of the GAD67-GFP (?
Positive_regulation (generation) of Gene_expression (generation) of GAD67
1) Confidence 0.48 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.36 Pain Relevance 0.04
Striatal expression of substance P and enkephalin mRNAs was reduced by about 50% and 30%, respectively, whereas the expression of GAD67 and GAD65 mRNAs was slightly increased and unaltered, respectively.
Positive_regulation (increased) of Gene_expression (expression) of GAD67 associated with enkephalin and substance p
2) Confidence 0.45 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11432985 Disease Relevance 0.09 Pain Relevance 0.66
Enhanced Fos expression in glutamic acid decarboxylase immunoreactive neurons of the mouse periaqueductal grey during opioid withdrawal.
Positive_regulation (Enhanced) of Gene_expression (expression) of glutamic acid decarboxylase in neurons associated with narcan, withdrawal, opioid and central grey
3) Confidence 0.44 Published 2006 Journal Neuroscience Section Title Doc Link 16359817 Disease Relevance 0.75 Pain Relevance 1.21
The expression of GAD67 and GAT-1 were evaluated in the thy1-CFP mouse retina.
Positive_regulation (evaluated) of Gene_expression (expression) of GAD67 in retina
4) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.13 Pain Relevance 0.09
This reduction contrasts with the lack of change or increase in glutamate decarboxylase-67 messenger RNA expression found in animals depleted of dopamine after lesions of the mesostriatal dopaminergic system.
Positive_regulation (increase) of Gene_expression (expression) of decarboxylase-67 associated with dopamine and glutamate
5) Confidence 0.10 Published 2000 Journal Neuroscience Section Abstract Doc Link 10974427 Disease Relevance 0.13 Pain Relevance 0.43

General Comments

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