INT90567

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.88
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
brain 2
basal ganglia 2
Gad1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 21 100.00 Very High Very High Very High
gABA 37 98.76 Very High Very High Very High
Enkephalin 3 92.40 High High
imagery 4 88.64 High High
dopamine receptor 2 85.48 High High
antagonist 10 82.72 Quite High
Dopamine 3 82.32 Quite High
GABAergic 2 72.64 Quite High
substance P 1 71.36 Quite High
hyperexcitability 1 69.84 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 19 99.92 Very High Very High Very High
Aggression 8 98.30 Very High Very High Very High
Ataxia 5 96.96 Very High Very High Very High
Syndrome 17 95.36 Very High Very High Very High
Stiff-person Syndrome 2 95.12 Very High Very High Very High
Obesity 57 91.48 High High
Urological Neuroanatomy 1 90.32 High High
Anorexia 14 83.64 Quite High
Muscle Rigidity 2 82.56 Quite High
Epilepsy 10 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In SI male mice, aggression can be prevented by treatment with L-methionine (MET), which has also been shown to decrease reelin and GAD67 mRNA expression and maintain normal brain Allo content.
Negative_regulation (decrease) of Gene_expression (expression) of GAD67 in brain associated with aggression
1) Confidence 0.41 Published 2004 Journal Crit Rev Neurobiol Section Abstract Doc Link 15581402 Disease Relevance 0.66 Pain Relevance 0.07
GABA-mediated synaptic transmission is thought to be functionally impaired by the production of autoantibodies to GAD65 and GAD67 [35-37].
Negative_regulation (impaired) of Gene_expression (production) of GAD67 associated with gaba
2) Confidence 0.36 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 1.60 Pain Relevance 0.46
In addition, D(2) receptor-deficient mice display a reduced expression of glutamate decarboxylase-67 messenger RNA in the globus pallidus, as the basal ganglia model predicts.
Negative_regulation (reduced) of Gene_expression (expression) of decarboxylase-67 in basal ganglia associated with glutamate
3) Confidence 0.09 Published 2000 Journal Neuroscience Section Abstract Doc Link 10974427 Disease Relevance 0.08 Pain Relevance 0.42
Also, approximately one-third of POMC/CART neurones express glutamic acid decarboxylase (GAD) mRNA [47].
Negative_regulation (neurones) of Gene_expression (express) of glutamic acid decarboxylase associated with generalized anxiety disorder
4) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.54 Pain Relevance 0.41

General Comments

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