INT90568

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Context Info
Confidence 0.27
First Reported 2000
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.46
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
neurons 2
basal ganglia 2
primary visual cortex 2
Gad1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 40 100.00 Very High Very High Very High
Glutamate 20 99.98 Very High Very High Very High
GABAergic 8 96.88 Very High Very High Very High
substance P 1 95.80 Very High Very High Very High
Dopamine 2 90.20 High High
Pyramidal cell 35 88.24 High High
Somatosensory cortex 3 76.40 Quite High
Enkephalin 1 71.52 Quite High
dopamine receptor 2 64.60 Quite High
Neurotransmitter 7 42.64 Quite Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 1 96.04 Very High Very High Very High
Generalized Anxiety Disorder 17 82.48 Quite High
Convulsion 3 74.16 Quite High
Attention Deficit Hyperactivity Disorder 1 73.04 Quite High
Disease 10 54.24 Quite High
Cerebral Palsy 43 50.00 Quite Low
Syndrome 14 50.00 Quite Low
Cleft Palate 4 23.60 Low Low
Movement Disorders 2 13.28 Low Low
Angelman Syndrome 1 6.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bond et al. [27] showed that GAD25 is expressed in a temporally controlled manner, in the developing striatum and cortex in rodents, suggesting this may provide a mechanism of regulating GABA production in differentiating neurons.
Regulation (controlled) of Gene_expression (expressed) of GAD25 in neurons associated with gaba
1) Confidence 0.27 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.24 Pain Relevance 0.27
Interestingly, in adult monkeys monocular deprivation modifies the expression of GABA and glutamic acid decarboxylase in the primary visual cortex in an eye-specific manner [49], suggesting that GABAergic transmission is sensitive to activity-dependent plasticity in the adult.
Regulation (modifies) of Gene_expression (expression) of glutamic acid decarboxylase in primary visual cortex associated with gaba and gabaergic
2) Confidence 0.09 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1318477 Disease Relevance 0 Pain Relevance 0.22
Finally, glutamate decarboxylase-67 messenger RNA expression in the basal ganglia output nuclei was not affected by mutations in the D(2) receptor gene, a fact that could probably be related to the absence of a parkinsonian locomotor phenotype in D(2) receptor-deficient mice.
Neg (not) Regulation (affected) of Gene_expression (expression) of decarboxylase-67 in basal ganglia associated with parkinson's disease and glutamate
3) Confidence 0.06 Published 2000 Journal Neuroscience Section Abstract Doc Link 10974427 Disease Relevance 0.22 Pain Relevance 0.40

General Comments

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