INT90603

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 103
Total Number 105
Disease Relevance 58.65
Pain Relevance 7.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Anatomy Link Frequency
lung 6
neurons 4
CAR 2
liver 2
brain 2
Ahr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1011 100.00 Very High Very High Very High
agonist 177 99.72 Very High Very High Very High
qutenza 3 99.60 Very High Very High Very High
cytokine 587 99.30 Very High Very High Very High
anesthesia 69 98.40 Very High Very High Very High
fibrosis 41 97.96 Very High Very High Very High
Paracetamol 12 97.56 Very High Very High Very High
withdrawal 35 97.52 Very High Very High Very High
chemokine 101 95.84 Very High Very High Very High
Neurotransmitter 100 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 2055 100.00 Very High Very High Very High
INFLAMMATION 1041 100.00 Very High Very High Very High
Hypersensitivity 378 100.00 Very High Very High Very High
Rhinitis 108 100.00 Very High Very High Very High
Eosinophilia 102 100.00 Very High Very High Very High
Aspergillus Infection 176 99.98 Very High Very High Very High
Infection 178 99.88 Very High Very High Very High
Respiratory Syncytial Virus 437 99.68 Very High Very High Very High
Sprains And Strains 227 99.64 Very High Very High Very High
Cancer 743 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AhR is activated not only by halogenated aromatic hydrocarbons (for example, dioxins) but also by polycyclic aromatic hydrocarbons.
Positive_regulation (activated) of AhR
1) Confidence 0.69 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.08 Pain Relevance 0
Transcriptional activation of exogenous AhR
Positive_regulation (activation) of AhR
2) Confidence 0.67 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.22 Pain Relevance 0
Effect of AhR activation on catecholaminergic differentiation
Positive_regulation (activation) of AhR
3) Confidence 0.67 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.09 Pain Relevance 0.07
Therefore, we attempted to analyze the participation of AhR activation following exposure of the developing neuron to TCDD, by producing and using N2a-R?
Spec (analyze) Positive_regulation (activation) of AhR in neuron
4) Confidence 0.67 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.36 Pain Relevance 0
We performed a preliminary screening of the inhibitory effects of vegetable constituents on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced activation of AhR using the AhR-based bioassay for dioxins, the Ah-Immunoassay.
Positive_regulation (activation) of AhR
5) Confidence 0.65 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 14646185 Disease Relevance 0 Pain Relevance 0.07
Curcumin, carnosol, and capsaicin also inhibited the activation of AhR in this assay, although to a lesser degree.
Positive_regulation (activation) of AhR associated with qutenza
6) Confidence 0.65 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 14646185 Disease Relevance 0 Pain Relevance 0.10
AhR activation in basal and atrophic cells may therefore be viewed as an anticancer mechanism.
Positive_regulation (activation) of AhR
7) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 1.11 Pain Relevance 0.12
-catenin stabilization and the AhR mRNA upregulation upon ?
Positive_regulation (upregulation) of AhR
8) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.49 Pain Relevance 0
We found that AhR is normally expressed at low levels in the prostatic epithelium basal cells (cytoplasmic and nuclear staining, Figure 6A) and is substantially upregulated in areas of proliferative inflammatory atrophy (PIA), considered a precursor lesion to cancer (Figure 6B).
Positive_regulation (upregulated) of AhR in basal cells associated with inflammation, cancer and frailty
9) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 1.09 Pain Relevance 0.12
Together these observations suggest that AhR activation may be a cancer counteracting mechanism in the prostate.
Positive_regulation (activation) of AhR associated with cancer
10) Confidence 0.62 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816705 Disease Relevance 0.64 Pain Relevance 0
-TrCP modulation is mediated via AhR upregulation.
Positive_regulation (upregulation) of AhR
11) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0 Pain Relevance 0
-TrCP inhibition, we carried a cDNA array analysis and observed an additive upregulation of the AhR (Figure 4).
Positive_regulation (upregulation) of AhR
12) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.86 Pain Relevance 0
RSV infection also induced AHR in both strains as evidenced by a greater difference between pre- and post-methacholine Penh values (delta Penh) compared with controls.
Positive_regulation (induced) of AHR associated with sprains and strains, infection and respiratory syncytial virus
13) Confidence 0.57 Published 2005 Journal Virol J Section Body Doc Link PMC1183251 Disease Relevance 2.37 Pain Relevance 0.03
The Penh increase was higher in the HDM-sensitized mice than in the non-sensitized mice, revealing the induction of AHR in the HDM-sensitized animals.
Positive_regulation (induction) of AHR associated with asthma
14) Confidence 0.54 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.44 Pain Relevance 0.05
Observing AhR upregulation upon ?
Positive_regulation (upregulation) of AhR
15) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.84 Pain Relevance 0.03
In contrast, using the in vitro DRESSA bioassay, we demonstrated that cigarette smoke has high levels of the dioxin-like potential for triggering the AhR–DRE pathway (Kasai et al. 2006a).
Positive_regulation (triggering) of AhR
16) Confidence 0.50 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.07 Pain Relevance 0
It is, in part, consistent with our result that activation of the AhR–DRE pathway was observed mainly in the liver in TCDD-exposed DRESSA mice.
Positive_regulation (activation) of AhR in liver
17) Confidence 0.50 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.10 Pain Relevance 0
Using the in vitro DRESSA bioassay (Kasai et al. 2004, 2005), we recently reported that cigarette smoke contains high levels of AhR agonists and strongly activates the AhR–DRE pathway (Kasai et al. 2006a).
Positive_regulation (activates) of AhR associated with agonist
18) Confidence 0.50 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.07 Pain Relevance 0.05
However, these mice have been used only to investigate activation of AhR or the Cyp1a1 promoter in specific organs or tissues after oral or ip administration of halogenated and polycyclic aromatic hydrocarbons.
Spec (investigate) Positive_regulation (activation) of AhR
19) Confidence 0.50 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.47 Pain Relevance 0
Significantly increased AHR was persistently present for 42 days post-inoculation in BALB/c mice, while C57BL/6 mice showed significantly increased AHR for up to 28 days post-inoculation (Figure 2).

2.

Positive_regulation (increased) of AHR
20) Confidence 0.50 Published 2005 Journal Virol J Section Body Doc Link PMC1183251 Disease Relevance 2.32 Pain Relevance 0.11

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