INT90604

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.52
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Anatomy Link Frequency
1A2 4
lung 4
Ahr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 100.00 Very High Very High Very High
Paracetamol 12 97.56 Very High Very High Very High
nMDA receptor 2 95.60 Very High Very High Very High
Action potential 1 93.80 High High
tetrodotoxin 4 92.80 High High
Inflammation 44 82.32 Quite High
fibrosis 3 62.96 Quite High
chemokine 6 54.72 Quite High
cytokine 45 53.52 Quite High
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilia 8 99.76 Very High Very High Very High
Prostate Cancer 168 99.60 Very High Very High Very High
Drug Induced Neurotoxicity 3 99.04 Very High Very High Very High
Cataract 12 98.44 Very High Very High Very High
Nicotine Addiction 68 85.84 High High
Hyperplasia 4 85.24 High High
Cancer 107 84.40 Quite High
INFLAMMATION 45 82.32 Quite High
Targeted Disruption 15 80.52 Quite High
Disease 39 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-TrCP modulation is mediated via AhR upregulation.
Positive_regulation (mediated) of Positive_regulation (upregulation) of AhR
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0 Pain Relevance 0
We therefore hypothesized that the upregulation of the AhR could be mediating the growth inhibitory effect of ?
Positive_regulation (mediating) of Positive_regulation (upregulation) of AhR
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.77 Pain Relevance 0
Observing AhR upregulation upon ?
Positive_regulation (Observing) of Positive_regulation (upregulation) of AhR
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.84 Pain Relevance 0.03
Our results show that activation of AhR by the selective agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin induced dioxin-responsive gene expression and calcium entry, which were attenuated by AhR small interfering RNA, the NMDA receptor channel blocker MK801, and the action potential blocker tetrodotoxin (TTX).
Positive_regulation (induced) of Positive_regulation (activation) of AhR associated with tetrodotoxin, action potential, nmda receptor and agonist
4) Confidence 0.29 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 17973980 Disease Relevance 0.17 Pain Relevance 0.51
Although we did not observe changes of the AHR at the gene expression level, Martey et al. (2005) recently reported that cigarette smoke extract led to an activation of the AHR in cultured human lung fibroblasts based on induced nuclear translocation of the AHR (Martey et al. 2005).
Positive_regulation (led) of Positive_regulation (activation) of AHR in lung
5) Confidence 0.28 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.22 Pain Relevance 0
These results support the hypothesis that the aromatic hydrocarbon receptor-independent induction of cytochrome P450 1A2 enzyme leads to accumulation of sufficient N-acetyl-p-benzoquinone in the liver and cataract development in the eye.
Positive_regulation (leads) of Neg (independent) Positive_regulation (induction) of aromatic hydrocarbon receptor in 1A2 associated with cataract
6) Confidence 0.20 Published 2000 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10977129 Disease Relevance 0.46 Pain Relevance 0.36
Aromatic hydrocarbons, such as beta-naphthoflavone, induce cytochrome P450 1A2 in C57BL6 mice via the mediation of the aromatic hydrocarbon receptor and render the animals susceptible to cataract formation by acetaminophen administration but not in DBA2 mice which do not respond to cytochrome P450 1A2 induction by these compounds.
Positive_regulation (induce) of Positive_regulation (mediation) of aromatic hydrocarbon receptor in 1A2 associated with paracetamol and cataract
7) Confidence 0.20 Published 2000 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10977129 Disease Relevance 0.33 Pain Relevance 0.43
Instillation of recombinant mouse IL-9 into the airways of B6 mice for up to 10 days resulted in time-dependent and dose-dependent increases in AHR, BAL eosinophilia, elevated IgE levels, increased lung proteases, and submucosal membrane thickening [51].
Positive_regulation (resulted) of Positive_regulation (increases) of AHR in lung associated with eosinophilia
8) Confidence 0.19 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.72 Pain Relevance 0.13

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