INT90611

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Context Info
Confidence 0.63
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.89
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
neurons 2
hippocampus 2
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 138 100.00 Very High Very High Very High
long-term potentiation 47 99.46 Very High Very High Very High
depression 47 99.40 Very High Very High Very High
Hippocampus 20 99.40 Very High Very High Very High
Periaqueductal grey 1 98.88 Very High Very High Very High
Ventral tegmentum 1 97.92 Very High Very High Very High
Spinal cord 36 96.40 Very High Very High Very High
Inflammation 36 92.80 High High
substance P 7 92.52 High High
Intracerebroventricular 2 91.84 High High
Disease Link Frequency Relevance Heat
Depression 47 99.40 Very High Very High Very High
Urological Neuroanatomy 1 98.88 Very High Very High Very High
INFLAMMATION 34 92.80 High High
Nociception 29 89.04 High High
Pain 22 85.44 High High
Nervous System Injury 2 82.04 Quite High
Drug Dependence 5 80.88 Quite High
Injury 26 80.00 Quite High
Stress 8 79.64 Quite High
Frailty 5 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicated that the heptapeptide induced a dose-dependent upregulation of the NR2A transcript in hippocampus, periaqueductal grey and ventral tegmental area, already within a few hours.
Positive_regulation (induced) of Positive_regulation (upregulation) of NR2A in hippocampus associated with ventral tegmentum, periaqueductal grey and hippocampus
1) Confidence 0.63 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10978586 Disease Relevance 0.26 Pain Relevance 1.08
From our findings we may conclude that the NR2A mRNA increases may not translate into increased levels of NR2A protein.
Positive_regulation (increased) of Positive_regulation (levels) of NR2A protein
2) Confidence 0.40 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.87 Pain Relevance 0.50
Inhibition of NMDA receptors blocks LTP and LTD induction, although recent studies using pharmacological NMDA receptor subtype blockade approach has proposed that LTP induction is specifically dependent on activation of NR2A-containing receptors and LTD requires activation of NR2B-containg receptors [39], [40].
Positive_regulation (dependent) of Positive_regulation (activation) of NR2A-containing associated with depression, nmda receptor and long-term potentiation
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.63 Pain Relevance 0.90
Additionally, ethanol (50 mM) - induced upregulation of NMDA receptor protein (NR1, NR2A and NR2B) in cultured rat hippocampal neurons, was completely prevented by memantine (10 ┬ÁM for 5 days; [160]).
Positive_regulation (induced) of Positive_regulation (upregulation) of NR2A in neurons associated with nmda receptor
4) Confidence 0.18 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.14 Pain Relevance 0.52

General Comments

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