INT90612

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 15.11
Pain Relevance 18.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
forebrain 3
hippocampus 2
spinal cord 1
caudate putamen 1
brain 1
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 521 100.00 Very High Very High Very High
Hippocampus 107 100.00 Very High Very High Very High
amygdala 27 100.00 Very High Very High Very High
antagonist 94 99.96 Very High Very High Very High
Inflammation 152 99.76 Very High Very High Very High
Morphine 52 99.70 Very High Very High Very High
Dorsal horn 41 99.68 Very High Very High Very High
cerebral cortex 6 99.68 Very High Very High Very High
long-term potentiation 458 99.46 Very High Very High Very High
depression 402 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 149 99.76 Very High Very High Very High
Brain Hemorrhage 78 99.56 Very High Very High Very High
Depression 402 99.40 Very High Very High Very High
Urological Neuroanatomy 6 98.88 Very High Very High Very High
Death 36 98.40 Very High Very High Very High
Diabetes Mellitus 95 97.84 Very High Very High Very High
Parkinson's Disease 8 97.80 Very High Very High Very High
Anxiety Disorder 103 97.76 Very High Very High Very High
Spinal Injuries 2 97.46 Very High Very High Very High
Cognitive Disorder 44 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NR2A mRNA was significantly decreased in the CA1 and CA3 of hippocampus in tolerant rats and increased in the cerebral cortex and dentate gyrus in butorphanol withdrawal rats.
Positive_regulation (increased) of NR2A in hippocampus associated with butorphanol, hippocampus, withdrawal and cerebral cortex
1) Confidence 0.65 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.61
The increase in the NR1, NR2A, and NR2B receptor mRNAs started at 5 h, maintained for 1-7 days (P < 0.05-0.001) and returned to the control level at 14 days after inflammation.
Positive_regulation (increase) of NR2A associated with inflammation
2) Confidence 0.63 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11826044 Disease Relevance 0.80 Pain Relevance 0.84
The results indicated that the heptapeptide induced a dose-dependent upregulation of the NR2A transcript in hippocampus, periaqueductal grey and ventral tegmental area, already within a few hours.
Positive_regulation (upregulation) of NR2A in hippocampus associated with ventral tegmentum, periaqueductal grey and hippocampus
3) Confidence 0.63 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10978586 Disease Relevance 0.26 Pain Relevance 1.08
From our findings we may conclude that the NR2A mRNA increases may not translate into increased levels of NR2A protein.
Neg (not) Positive_regulation (increases) of NR2A protein
4) Confidence 0.60 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.88 Pain Relevance 0.50
From our findings we may conclude that the NR2A mRNA increases may not translate into increased levels of NR2A protein.
Neg (not) Positive_regulation (increases) of NR2A
5) Confidence 0.60 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.86 Pain Relevance 0.48
However, Gaunitz et al. did find a modest increase in NR2A and NR2C mRNA.
Positive_regulation (increase) of NR2A
6) Confidence 0.60 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.86 Pain Relevance 0.45
MDMA increased mRNA expression levels of glutamatergic NMDA receptor subunits NR1, NR2A and NR2B in the forebrain cortex, NR2A and 2B in the CPU, and NR1 and NR2A (lower dose) in the hypothalamus.
Positive_regulation (increased) of NR2A in forebrain associated with nmda receptor
7) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0.29
These results suggest that region-specific changes of NMDA receptor subunit mRNA (NR1 and NR2) as well as NMDA receptor binding ([3H]MK-801) are involved in the development of tolerance to and withdrawal from butorphanol.
Positive_regulation (changes) of NR2 associated with nmda receptor, butorphanol, tolerance and withdrawal
8) Confidence 0.47 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.58
We also found significant increases in NR2C and NR2D subunits, but not in NR2A or NR2B.
Positive_regulation (increases) of NR2A
9) Confidence 0.46 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.03 Pain Relevance 0.10
Significant increase of NR2A 3 h after focal cerebral ischemia might couple with the compensatory response to diminish the Ca2+ which is associated with lower affinity for glutamate and considerably shorter offset decay time for Ca2+ compared with those of NR2B-containing NMDA receptors.
Positive_regulation (increase) of NR2A associated with brain hemorrhage, glutamate, nmda receptor and ischemia
10) Confidence 0.46 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.51 Pain Relevance 0.57
Moreover, it was reported that the transcript levels for GluR1, GluR2, GluR3, NR2A, and NR2B subunits are significantly upregulated in the dorsal horn of the spinal cord in STZ-induced diabetic rats [21].
Positive_regulation (upregulated) of NR2A in spinal cord associated with diabetes mellitus, dorsal horn and spinal cord
11) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 1.19 Pain Relevance 0.45
When it comes to the role of NR2A and NR2B subunits, we found that the NMDA-induced depotentiation was largely blocked by NVP but was little influenced by Ro/Ife, suggesting predominant involvement of NR2A-containing NMDARs.
Positive_regulation (involvement) of NR2A-containing
12) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.68 Pain Relevance 0.33
Western blot analysis indicated that the protein translation products of the NR2A subunit were also increased (P < 0.01).
Positive_regulation (increased) of NR2A subunit
13) Confidence 0.42 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11826044 Disease Relevance 0.86 Pain Relevance 0.94
We also investigated the effect of intra-CA1 blockade of NR2A-NMDARs, using the relatively selective NR2A-NMDAR antagonist NVP-AAM077.
Positive_regulation (selective) of NR2A-NMDAR associated with antagonist
14) Confidence 0.42 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.33 Pain Relevance 0.17
In the genetic section of the study, results of quantitative real-time RT-PCR clearly indicated that morphine sensitization increased the expression of NMDA receptor subunits mRNA in the amygdala (NR1 by 104% and NR2A by 85%), while the other areas of the brain were unaffected.
Positive_regulation (increased) of NR2A in brain associated with nmda receptor, amygdala and morphine
15) Confidence 0.41 Published 2008 Journal Pharmacology Section Abstract Doc Link 18391508 Disease Relevance 0 Pain Relevance 1.21
Real-time RT-PCR showed that NR2B and NR2D were expressed at higher levels than NR2A and NR2C in DRG.
Positive_regulation (levels) of NR2A in DRG
16) Confidence 0.40 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11954032 Disease Relevance 0.09 Pain Relevance 0.25
The signals for NMDA subunits, NR2A, -2B and -2C, in the gracile nucleus neurons were not prominent, suggesting a low level expression of functional NMDA receptor complex.
Neg (not) Positive_regulation (prominent) of NR2A in gracile nucleus associated with nmda receptor
17) Confidence 0.40 Published 2002 Journal Pain Section Abstract Doc Link 11790478 Disease Relevance 0.56 Pain Relevance 0.68
From our findings we may conclude that the NR2A mRNA increases may not translate into increased levels of NR2A protein.
Positive_regulation (increased) of NR2A protein
18) Confidence 0.40 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.87 Pain Relevance 0.50
From our findings we may conclude that the NR2A mRNA increases may not translate into increased levels of NR2A protein.
Positive_regulation (levels) of NR2A protein
19) Confidence 0.40 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.86 Pain Relevance 0.49
This was explained by assuming that LTP-inducing stimuli normally activate both NR2A- and NR2B-type receptors, and so might induce both LTP and LTD, but yielding potentiation as net result.
Positive_regulation (activate) of NR2A associated with depression and long-term potentiation
20) Confidence 0.40 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.67 Pain Relevance 0.62

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