INT90639

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 10.95
Pain Relevance 10.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
striatum 8
nucleus accumbens 1
neuroblasts 1
cortex 1
prefrontal 1
Slc6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1782 100.00 Very High Very High Very High
cocaine 444 99.64 Very High Very High Very High
Ventral tegmentum 35 99.64 Very High Very High Very High
monoamine 76 99.60 Very High Very High Very High
imagery 19 99.40 Very High Very High Very High
midbrain 209 98.72 Very High Very High Very High
Nucleus accumbens 129 98.68 Very High Very High Very High
Eae 139 97.60 Very High Very High Very High
Central nervous system 15 96.36 Very High Very High Very High
Enkephalin 12 91.24 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 218 100.00 Very High Very High Very High
Parkinson's Disease 467 99.66 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1039 99.36 Very High Very High Very High
Drug Induced Neurotoxicity 39 99.12 Very High Very High Very High
Apoptosis 50 98.32 Very High Very High Very High
Urological Neuroanatomy 16 96.64 Very High Very High Very High
Congenital Anomalies 24 95.52 Very High Very High Very High
Disease 343 91.08 High High
Stress 38 87.48 High High
Aging 56 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the extent of basal DA elevation in DAT-CI mice is between those in heterozygous DAT-KO and DAT-KD mice [17], it is reasonable to assume that the adaptive changes in DAT-CI mice are also moderate and do not interrupt the drug reward pathway.
Positive_regulation (elevation) of DAT-CI associated with dopamine
1) Confidence 0.61 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.53
The present findings suggest that the neurotoxicity of MPTP to neuroblasts in the SVZ does not require DAT or other monoamine transporters, and the apoptosis it induces may be executed through other unknown pathways.
Neg (not) Positive_regulation (require) of DAT in neuroblasts associated with parkinson's disease, drug induced neurotoxicity, apoptosis and monoamine
2) Confidence 0.51 Published 2009 Journal Neurotoxicology Section Abstract Doc Link 19616025 Disease Relevance 1.28 Pain Relevance 0.39
Although the elevated basal DA tone is due to reduced DAT activity in all mouse lines, the causes of the reduction are different; reduced expression of wild type DAT, in heterozygous DAT-KO and DAT-KD mice, versus normal expression of a mutant DAT with lower uptake activity in DAT-CI mice.
Positive_regulation (due) of DAT associated with dopamine
3) Confidence 0.50 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.47
Here, we show that DADLE was able to block the protein as well as the functional loss of dopamine transporter (DAT) and tyrosine hydroxylase (TH) induced by methamphetamine.
Positive_regulation (induced) of dopamine transporter associated with dopamine
4) Confidence 0.48 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10980266 Disease Relevance 0 Pain Relevance 0.30
Here, we show that DADLE was able to block the protein as well as the functional loss of dopamine transporter (DAT) and tyrosine hydroxylase (TH) induced by methamphetamine.
Positive_regulation (induced) of DAT associated with dopamine
5) Confidence 0.48 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10980266 Disease Relevance 0 Pain Relevance 0.30
However, several lines of evidence support a predominant role of DAT-mediated recycling of DA for the maintenance of the large storage pool in DA terminals.
Positive_regulation (role) of DAT-mediated associated with dopamine
6) Confidence 0.46 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.12 Pain Relevance 0.74
To minimize interference with DAT function by preservation of both DAT alleles, Cre recombinase expression was driven from the 3?
Positive_regulation (preservation) of DAT
7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.16 Pain Relevance 0.24
The fact that cocaine retains these effects in both heterozygous DAT-KO mice and DAT-KD mice indicates that the reduction of DAT expression and thus DAT activity to 50% and 10% of wild type mice does not by itself lead to adaptive changes that abolish the stimulating effect of cocaine and in fact, 10% DAT activity seems to be sufficient for the preservation of many normal functions, such as some cocaine responses.
Positive_regulation (sufficient) of DAT associated with cocaine
8) Confidence 0.44 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.71
For instance, both 5 and 10 mg/kg cocaine produced stronger locomotor stimulation in DAT-KD mice than it did in wild type mice (Fig. 1D).
Positive_regulation (stimulation) of DAT-KD associated with cocaine
9) Confidence 0.44 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.61
In DAT-Cre conditional transgenic mice, Cre recombinase activity is induced shortly after DAT induction.
Positive_regulation (induction) of DAT associated with targeted disruption
10) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.33 Pain Relevance 0.39
By contrast, in mice fed with HCT1026, TH and DAT mRNAs (Figure 2A, B, C and 2D) and DAT mRNA (Figure 2E, F, G and 2H) levels were significantly increased compared with those measured in MPTP mice fed with a control diet, thus supporting HCT1026-induced striatal DAergic neuroprotection was maintained at long time intervals.
Positive_regulation (increased) of DAT mRNA associated with parkinson's disease
11) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.48 Pain Relevance 0.09
In DAT-Cre conditional transgenic mice, Cre recombinase activity is induced shortly after DAT induction.
Positive_regulation (induced) of DAT-Cre associated with targeted disruption
12) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.35 Pain Relevance 0.40
ADHD patients have also been found to show higher levels of DAT1 in the striatum [45].
Positive_regulation (levels) of DAT1 in striatum associated with attention deficit hyperactivity disorder
13) Confidence 0.39 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.66 Pain Relevance 0.26
Gene expression, measured using quantitative real-time PCR, revealed a significant approximately 3- to 10-fold up-regulation of dopamine reuptake transporter (DAT) in the ventral tegmental area, nucleus accumbens, and prefrontal cortex and a down-regulation of DAT in the hypothalamus.
Positive_regulation (up-regulation) of DAT in prefrontal associated with nucleus accumbens, ventral tegmentum and dopamine
14) Confidence 0.39 Published 2010 Journal Endocrinology Section Abstract Doc Link 20685869 Disease Relevance 0.21 Pain Relevance 0.67
While peak HTO frequencies increase in WT and DAT-KO mice following novelty-induced hyperactivity as well, the changes in baseline HTO's observed in DAT-KO mice are unlikely to be due to gross locomotor behavioral changes.
Positive_regulation (increase) of DAT-KO associated with targeted disruption and attention deficit hyperactivity disorder
15) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668764 Disease Relevance 0.65 Pain Relevance 0.15
By contrast, in mice fed with HCT1026, TH and DAT mRNAs (Figure 2A, B, C and 2D) and DAT mRNA (Figure 2E, F, G and 2H) levels were significantly increased compared with those measured in MPTP mice fed with a control diet, thus supporting HCT1026-induced striatal DAergic neuroprotection was maintained at long time intervals.
Positive_regulation (increased) of DAT associated with parkinson's disease
16) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.49 Pain Relevance 0.10
They measured the expression and activity of the dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT2) in presynaptic terminals of dopaminergic neurons in the striatum.
Positive_regulation (activity) of DAT in striatum associated with dopamine and monoamine
17) Confidence 0.22 Published 2010 Journal Neurology Research International Section Body Doc Link PMC2989867 Disease Relevance 0.51 Pain Relevance 0.31
They measured the expression and activity of the dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT2) in presynaptic terminals of dopaminergic neurons in the striatum.
Positive_regulation (activity) of dopamine transporter in striatum associated with dopamine and monoamine
18) Confidence 0.22 Published 2010 Journal Neurology Research International Section Body Doc Link PMC2989867 Disease Relevance 0.51 Pain Relevance 0.31
were observed in the striatum of dopamine transporter (DAT) KO mice [16].
Positive_regulation (striatum) of dopamine transporter in striatum associated with targeted disruption and dopamine
19) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.89 Pain Relevance 0.08
Gene expression, measured using quantitative real-time PCR, revealed a significant approximately 3- to 10-fold up-regulation of dopamine reuptake transporter (DAT) in the ventral tegmental area, nucleus accumbens, and prefrontal cortex and a down-regulation of DAT in the hypothalamus.
Positive_regulation (up-regulation) of DAT in nucleus accumbens associated with nucleus accumbens, ventral tegmentum and dopamine
20) Confidence 0.13 Published 2010 Journal Endocrinology Section Abstract Doc Link 20685869 Disease Relevance 0.21 Pain Relevance 0.67

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