INT9064

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Context Info
Confidence 0.62
First Reported 1982
Last Reported 2008
Negated 2
Speculated 2
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 0.61
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt2b)
Anatomy Link Frequency
liver 5
intestine 1
Ugt2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 22 100.00 Very High Very High Very High
Morphine 13 95.76 Very High Very High Very High
alcohol 5 85.52 High High
anticonvulsant 1 50.56 Quite High
agonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Malaria 3 100.00 Very High Very High Very High
Infection 3 100.00 Very High Very High Very High
Injury 2 95.80 Very High Very High Very High
Acute-phase Reaction 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of dietary lipids on levels of UDP-glucuronosyltransferase in liver.
Regulation (Effect) of UDP-glucuronosyltransferase in liver
1) Confidence 0.62 Published 1992 Journal Biochem. Pharmacol. Section Title Doc Link 1642647 Disease Relevance 0.10 Pain Relevance 0.19
UGT1A and UGT2B family isoforms were differentially affected by endotoxin treatment.
Regulation (affected) of UGT2B
2) Confidence 0.57 Published 2008 Journal Drug Metab Lett Section Abstract Doc Link 19356101 Disease Relevance 0.07 Pain Relevance 0.31
The effect of pregnenolone-16 alpha-carbonitrile (PCN) on UDP-glucuronosyltransferase (UDP-GT) activity was comprehensively examined in Wistar (JJ), heterozygous (Jj) and Gunn (jj) rats with eleven different acceptors for glucuronic acid.
Spec (examined) Regulation (effect) of UDP-glucuronosyltransferase
3) Confidence 0.53 Published 1982 Journal Drug Metab. Dispos. Section Abstract Doc Link 6130905 Disease Relevance 0 Pain Relevance 0
The effect of malaria infection on UDP-glucuronosyltransferase (UDPGT) activity was investigated in rat liver microsomes using 3'-azido-3'-deoxythymidine and paracetamol.
Regulation (effect) of UDP-glucuronosyltransferase in liver associated with malaria, paracetamol and infection
4) Confidence 0.52 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1449539 Disease Relevance 0.35 Pain Relevance 0.17
In rats, these changes were associated with a 30-fold elevation in the Vmax for microsomal ethoxyresorufin O-deethylase and a moderate increase in the Vmax for microsomal ethylmorphine N-demethylase, but no change in either the rate of aniline p-hydroxylation, 4-hydroxybiphenyl- or 4-methylumbelliferone UDP-glucuronosyltransferase, or the activity of the flavoprotein reductase component.
Neg (no) Regulation (change) of UDP-glucuronosyltransferase
5) Confidence 0.32 Published 1987 Journal Drug Metab. Dispos. Section Abstract Doc Link 2888633 Disease Relevance 0 Pain Relevance 0.28
Differential effects of perfluorodecanoic acid (PFDA) on rat liver UDP-glucuronosyltransferase isoenzymes have been observed after a single i.p. administration of the compound to young male Sprague-Dawley rats. (1) Bilirubin glucuronidation was induced 2-fold.
Regulation (effects) of UDP-glucuronosyltransferase in liver
6) Confidence 0.31 Published 1991 Journal Chem. Biol. Interact. Section Abstract Doc Link 1898504 Disease Relevance 0 Pain Relevance 0.08
We therefore have determined how the amount and type of lipid in the diet affect the activity of liver microsomal UDP-glucuronosyltransferase activity.
Regulation (affect) of UDP-glucuronosyltransferase in liver
7) Confidence 0.27 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1642647 Disease Relevance 0.09 Pain Relevance 0.18
Microsomal UDP-glucuronosyltransferase activities towards a third group of substrates (including oestrone, phenolphthalein, paracetamol and oxazepam) are not markedly altered by treatment with either 3-methylcholanthrene or phenobarbital.
Neg (not) Regulation (altered) of UDP-glucuronosyltransferase associated with paracetamol
8) Confidence 0.27 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6422942 Disease Relevance 0 Pain Relevance 0.10
The alteration in nutritional status affected hepatic cytochrome P450 and UDP-glucuronosyltransferase (UGT) levels.
Regulation (affected) of UDP-glucuronosyltransferase
9) Confidence 0.27 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0
The effect of cytotoxic drug administration, as a single dose i.p. to rats (six rats/treatment group), on hepatic microsomal UDP-glucuronosyltransferase (UGT) activity was investigated.
Spec (investigated) Regulation (effect) of UDP-glucuronosyltransferase
10) Confidence 0.24 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1510722 Disease Relevance 0 Pain Relevance 0.18
Effects of microsomal enzyme inducers upon UDP-glucuronic acid concentration and UDP-glucuronosyltransferase activity in the rat intestine and liver.
Regulation (Effects) of UDP-glucuronosyltransferase in intestine
11) Confidence 0.22 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 1386480 Disease Relevance 0 Pain Relevance 0.36
Effects of microsomal enzyme inducers upon UDP-glucuronic acid concentration and UDP-glucuronosyltransferase activity in the rat intestine and liver.
Regulation (Effects) of UDP-glucuronosyltransferase in liver
12) Confidence 0.07 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 1386480 Disease Relevance 0 Pain Relevance 0.36

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