INT90675

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Context Info
Confidence 0.46
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 11.11
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Anatomy Link Frequency
heart 4
fat 2
sciatic nerves 2
umbilical vein 2
pulmonary artery 2
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 8 100.00 Very High Very High Very High
Sciatic nerve 7 100.00 Very High Very High Very High
Etanercept 6 99.38 Very High Very High Very High
aspirin 11 99.14 Very High Very High Very High
Bioavailability 11 98.92 Very High Very High Very High
ischemia 90 97.84 Very High Very High Very High
lidocaine 1 97.00 Very High Very High Very High
Inflammation 26 96.04 Very High Very High Very High
diabetic neuropathy 47 91.76 High High
Calcium channel 6 84.48 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 150 100.00 Very High Very High Very High
Apoptosis 14 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 8 100.00 Very High Very High Very High
Toxicity 1 100.00 Very High Very High Very High
Hypoxia 60 99.76 Very High Very High Very High
Chronic Renal Failure 10 99.24 Very High Very High Very High
Hypertension 52 99.04 Very High Very High Very High
Hypertrophy 37 98.92 Very High Very High Very High
Congenital Anomalies 25 98.56 Very High Very High Very High
Arthritis 9 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelial nitric oxide synthase expression, measured to assess ANTU-related endothelial toxicity, decreased significantly in ANTU-treated rats and fell even more sharply when G-CSF was given.
Negative_regulation (decreased) of Gene_expression (expression) of Endothelial nitric oxide synthase associated with toxicity
1) Confidence 0.46 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12524378 Disease Relevance 0.85 Pain Relevance 0.10
The mucosal expression levels of eNOS and iNOS but not nNOS mRNAs were enhanced in arthritic rats compared with normal rats.
Negative_regulation (levels) of Gene_expression (expression) of eNOS associated with arthritis
2) Confidence 0.41 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19881222 Disease Relevance 1.14 Pain Relevance 0.20
Therefore, the goals of the present study were to 1) demonstrate that rats fed a high sucrose or high fat diet gain more adiposity compared to Chow fed controls, 2) show that ROS levels were increased in the plasma as well as in small mesenteric resistance arterioles of high sucrose as well as high fat fed rats, 3) determine if eNOS protein expression is reduced in rats fed either diet thereby contributing to impaired vasodilation, and 4) test whether ROS or inflammatory pathways are involved in the impaired endothelium-dependent vasodilation that occurs after 6 weeks of high sucrose or high fat intake.


Negative_regulation (reduced) of Gene_expression (expression) of eNOS in fat associated with inflammation and increased venous pressure under development
3) Confidence 0.37 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0.79 Pain Relevance 0.09
Western blot analysis showed that both eNOS and iNOS expressions in the sciatic nerves of rats increased significantly during the peak stage of EAN, but declined thereafter.
Negative_regulation (declined) of Gene_expression (expressions) of eNOS in sciatic nerves associated with sciatic nerve and neuritis
4) Confidence 0.37 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12020959 Disease Relevance 0.75 Pain Relevance 0.91
These alterations with the exception of eNOS expression were significantly blocked by benidipine treatment.
Neg (exception) Negative_regulation (exception) of Gene_expression (expression) of eNOS
5) Confidence 0.37 Published 2002 Journal Diabetologia Section Body Doc Link 11914746 Disease Relevance 0.06 Pain Relevance 0
Here we show that EDTA is able to maintain the expression of eNOS on the glomerular and interstitial capillaries after Isc and Isc/R.
Negative_regulation (maintain) of Gene_expression (expression) of eNOS associated with ischemia
6) Confidence 0.34 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 0.92 Pain Relevance 0.25
High-dose aspirin, etanercept and high-dose meloxicam, each suppressed the retinal expression of eNOS and the DNA-binding capacity of retinal nuclear factor-kappaB.
Negative_regulation (suppressed) of Gene_expression (expression) of eNOS associated with aspirin and etanercept
7) Confidence 0.27 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 0.78 Pain Relevance 0.76
Pravastatin reduced the development of MCT-induced PAH and improved endothelium-dependent pulmonary artery relaxation through reduced apoptosis and a restored eNOS expression of endothelial cells [37].
Negative_regulation (reduced) of Gene_expression (expression) of eNOS in pulmonary artery associated with pulmonary hypertension and apoptosis
8) Confidence 0.24 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 1.60 Pain Relevance 0.11
The expression of endothelial NO synthase (eNOS) has been shown to be reduced in both rats (Comini et al., 1996) and dogs (Smith et al., 1996) with experimental heart failure.


Negative_regulation (reduced) of Gene_expression (expression) of endothelial NO synthase in heart associated with myocardial infarction
9) Confidence 0.22 Published 2008 Journal Microvasc Res Section Body Doc Link PMC2666799 Disease Relevance 0.88 Pain Relevance 0.05
In endothelial cells from human umbilical vein, hypoxic incubation inhibits eNOS expression (11) whereas it is associated with increase in both eNOS protein and mRNA (12) in endothelial cells from bovine aorta.
Negative_regulation (inhibits) of Gene_expression (expression) of eNOS in umbilical vein associated with hypoxia
10) Confidence 0.22 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808559 Disease Relevance 0.58 Pain Relevance 0
endoneurial hypoxemia caused by impaired eNOS expression and NO activity,
Negative_regulation (impaired) of Gene_expression (expression) of eNOS
11) Confidence 0.21 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.65 Pain Relevance 0.12
No differences in the protein expression of AKT2, SERCA2a, or PI3Kbeta were observed, and the observed trend towards reduction in eNOS expression might be expected to diminish cardiac function rather than improve it.
Negative_regulation (reduction) of Gene_expression (expression) of eNOS
12) Confidence 0.21 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.19 Pain Relevance 0
The expression of endothelial NO synthase (eNOS) has been shown to be reduced in both rats (Comini et al., 1996) and dogs (Smith et al., 1996) with experimental heart failure.


Negative_regulation (reduced) of Gene_expression (expression) of eNOS in heart associated with myocardial infarction
13) Confidence 0.16 Published 2008 Journal Microvasc Res Section Body Doc Link PMC2666799 Disease Relevance 0.88 Pain Relevance 0.05
AGEs have been shown to inhibit eNOS activity and expression (Verbeke et al 2000; Rojas et al 2000).
Negative_regulation (inhibit) of Gene_expression (expression) of eNOS
14) Confidence 0.15 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993980 Disease Relevance 0.30 Pain Relevance 0
Accordingly, the expression of ecNOS and iNOS mRNA was decreased in the glomeruli in CRF.
Negative_regulation (decreased) of Gene_expression (expression) of ecNOS associated with chronic renal failure
15) Confidence 0.07 Published 2000 Journal J. Korean Med. Sci. Section Abstract Doc Link 10983691 Disease Relevance 0.74 Pain Relevance 0.07

General Comments

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