INT90687

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Context Info
Confidence 0.64
First Reported 2000
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0.88
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
hypothalamus 1
striatum 1
forebrain 1
cortex 1
hippocampus 1
Tdo2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 4 99.98 Very High Very High Very High
Paracetamol 5 99.14 Very High Very High Very High
Analgesic 1 98.72 Very High Very High Very High
Hippocampus 4 97.88 Very High Very High Very High
antidepressant 12 85.84 High High
agonist 8 84.32 Quite High
fluoxetine 4 74.96 Quite High
Raphe 4 67.04 Quite High
Locus ceruleus 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 12 86.44 High High
Targeted Disruption 4 59.60 Quite High
Stress 4 30.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of the analgesic agent, acetaminophen was determined on rat forebrain serotonin levels as well as hepatic tryptophan-2,3-dioxygenase (TDO) activity and urinary 5-hydroxyindole acetic acid (5-HIAA).
Spec (determined) Gene_expression (levels) of TDO in forebrain associated with paracetamol, analgesic and serotonin
1) Confidence 0.64 Published 2000 Journal Life Sci. Section Abstract Doc Link 10983867 Disease Relevance 0 Pain Relevance 0.59
SR58611A (3 and 10 mg/kg, p.o.) increased the synthesis of 5-HT and tryptophan (Trp) levels in several rodent brain areas (cortex, hippocampus, hypothalamus, striatum).
Gene_expression (synthesis) of tryptophan in cortex associated with hippocampus
2) Confidence 0.02 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691638 Disease Relevance 0.22 Pain Relevance 0.32
SR58611A (3 and 10 mg/kg, p.o.) increased the synthesis of 5-HT and tryptophan (Trp) levels in several rodent brain areas (cortex, hippocampus, hypothalamus, striatum).
Gene_expression (synthesis) of tryptophan in hypothalamus associated with hippocampus
3) Confidence 0.01 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691638 Disease Relevance 0.22 Pain Relevance 0.32
SR58611A (3 and 10 mg/kg, p.o.) increased the synthesis of 5-HT and tryptophan (Trp) levels in several rodent brain areas (cortex, hippocampus, hypothalamus, striatum).
Gene_expression (synthesis) of tryptophan in hippocampus associated with hippocampus
4) Confidence 0.01 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691638 Disease Relevance 0.22 Pain Relevance 0.32
SR58611A (3 and 10 mg/kg, p.o.) increased the synthesis of 5-HT and tryptophan (Trp) levels in several rodent brain areas (cortex, hippocampus, hypothalamus, striatum).
Gene_expression (synthesis) of tryptophan in striatum associated with hippocampus
5) Confidence 0.01 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691638 Disease Relevance 0.22 Pain Relevance 0.32

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