INT90703

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.73
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
DRG 2
stem cells 2
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 26 100.00 Very High Very High Very High
allodynia 3 95.56 Very High Very High Very High
Pain 2 94.00 High High
Neuropathic pain 1 80.56 Quite High
Opioid 2 78.64 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 95.56 Very High Very High Very High
Pain 1 94.00 High High
Embryonal Carcinoma 2 91.04 High High
Nervous System Injury 4 79.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nitric oxide (NO) suppressed the transcription of the mouse kappa opioid receptor (KOR) gene, mediated by a rapid downregulation of c-myc gene expression.
Positive_regulation (mediated) of Transcription (transcription) of KOR associated with kappa opioid receptor
1) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.09 Pain Relevance 0.21
Expression of total KOR and variants B and C mRNA increased ipsilaterally in dorsal root ganglia (DRG) of PB+ mice, whereas KOR variant A mRNA was not detected in DRG.
Positive_regulation (increased) of Transcription (Expression) of KOR in DRG associated with kappa opioid receptor
2) Confidence 0.41 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10984632 Disease Relevance 0.58 Pain Relevance 0.77
It is proposed that NO regulates KOR at the level of gene transcription, mediated by a rapid suppression of c-myc gene expression and its binding to KOR promoters, and followed by chromatin hypoacetylation of and reduced transcription from KOR promoters in P19 stem cells.
Positive_regulation (level) of Transcription (transcription) of KOR in stem cells associated with kappa opioid receptor
3) Confidence 0.40 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.06 Pain Relevance 0.44

General Comments

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