INT90715

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Context Info
Confidence 0.73
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 1.64
Pain Relevance 7.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
lateral areas 2
sciatic nerve 1
medial 1
striatum 1
adrenal gland 1
Egr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 20 99.88 Very High Very High Very High
withdrawal 5 99.62 Very High Very High Very High
Dopamine 224 99.60 Very High Very High Very High
c fibre 25 99.56 Very High Very High Very High
Sciatic nerve 5 99.54 Very High Very High Very High
qutenza 3 99.54 Very High Very High Very High
antagonist 22 98.94 Very High Very High Very High
Opioid 2 98.72 Very High Very High Very High
cocaine 105 98.12 Very High Very High Very High
narcan 5 96.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 14 100.00 Very High Very High Very High
Stress 8 99.84 Very High Very High Very High
Bordatella Infection 1 99.40 Very High Very High Very High
Shock 2 94.00 High High
Nociception 4 85.60 High High
Urological Neuroanatomy 2 77.56 Quite High
Opiate Addiction 2 69.36 Quite High
Targeted Disruption 2 28.32 Quite Low
Repression 3 27.60 Quite Low
Cocaine Dependence 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Egr2 expression was substantially more induced by METH injection in the intact side (6.1-fold) of the hemiparkinsonian rats in comparison to control animals (3.8-fold) (Table 6).
Gene_expression (expression) of Egr2
1) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.11
Thus, the steady-state increases in DA released in the synaptic cleft of the 6-OHDA-treated animals might cause potentiated transcriptional sensitivity to METH-mediated DA-induced changes in Egr2 and Egr3 expression in the intact striatum.


Gene_expression (expression) of Egr2 in striatum associated with dopamine
2) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.39
Expression of the genes encoding Per2, Dbp, Arc, Egr1, Krox20 and NGFI-B was suppressed during inhalation of sevoflurane for 2 h and 6 h.
Gene_expression (Expression) of Krox20 associated with aids-related complex
3) Confidence 0.69 Published 2007 Journal Brain Res. Section Abstract Doc Link 17942082 Disease Relevance 0.10 Pain Relevance 0.69
In this study, we studied the effect of capsaicin-induced stress on the expression of the immediate-early genes (IEGs) NGFI-A, -B, -C, egr-2, -3 and Nurr1 in the rat adrenal gland using in situ hybridization.
Gene_expression (expression) of egr-2 in adrenal gland associated with stress and qutenza
4) Confidence 0.62 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986333 Disease Relevance 0.41 Pain Relevance 0.27
Although the suppression tended to be alleviated after awakening from anesthesia, the expression levels after a recovery period of 24 h remained significantly lower than the control levels of these genes, except for Krox20.
Gene_expression (expression) of Krox20 associated with anesthesia
5) Confidence 0.60 Published 2007 Journal Brain Res. Section Abstract Doc Link 17942082 Disease Relevance 0.09 Pain Relevance 0.71
The opioid antagonist, in turn, precipitated withdrawal and increased the expression of a set of genes which are predominantly transcription factors (krox20, CREM, NGFI-B, IkappaB, etc).
Gene_expression (expression) of krox20 associated with antagonist, withdrawal and opioid
6) Confidence 0.54 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12670709 Disease Relevance 0.55 Pain Relevance 1.05
Arc, Beta-catenin, Cap2, Crip2, Dnm2, Egr2, Fos, Fut8, GFAP, Gpr88, Htr1d, and Nr4a1 were all confirmed by qPCR to be differentially expressed.
Gene_expression (expressed) of Egr2 associated with aids-related complex
7) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.26 Pain Relevance 0.47
A weak C-fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c-Fos, FosB, Krox-20 or Krox-24; but it did reduce the basal expressions of c-Jun and JunD in both the medial and lateral areas.
Gene_expression (expression) of Krox-20 in lateral areas associated with c fibre
8) Confidence 0.36 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.73
An intense input produced by electrical stimulation of all the C-fibers in one sciatic nerve also failed to induce expression of c-Fos, FosB, Krox-20 or Krox-24 in the medial or lateral areas.
Gene_expression (expression) of Krox-20 in lateral areas associated with c fibre and sciatic nerve
9) Confidence 0.36 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.78
This simultaneous stimulation was the only type of stimulation to induce expression of Krox-20.
Gene_expression (expression) of Krox-20
10) Confidence 0.36 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0.05 Pain Relevance 0.52
A brief, strong electrical stimulation of sciatic nerve C-fibres induced little or no expression of c-Fos or Krox-20.
Gene_expression (expression) of Krox-20 in sciatic nerve associated with c fibre and sciatic nerve
11) Confidence 0.36 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0.09 Pain Relevance 0.45
Conversely, LSD but not lisuride increases the cortical expression of egr-1 and egr-2 by activating pertussis toxin-sensitive Gi/o proteins and Src (González-Maeso et al. 2007).
Gene_expression (expression) of egr-2 associated with bordatella infection
12) Confidence 0.29 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2797624 Disease Relevance 0.10 Pain Relevance 0.25
A weak C-fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c-Fos, FosB, Krox-20 or Krox-24; but it did reduce the basal expressions of c-Jun and JunD in both the medial and lateral areas.
Gene_expression (expression) of Krox-20 in medial associated with c fibre
13) Confidence 0.12 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.73

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