INT90718

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
striatum 2
adrenal gland 2
Egr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 3 100.00 Very High Very High Very High
Dopamine 106 99.82 Very High Very High Very High
medulla 5 97.76 Very High Very High Very High
nMDA receptor 1 64.48 Quite High
Glutamate 4 58.80 Quite High
agonist 12 29.44 Quite Low
Catecholamine 1 25.00 Low Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 7 100.00 Very High Very High Very High
Disease 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Gliosis 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the steady-state increases in DA released in the synaptic cleft of the 6-OHDA-treated animals might cause potentiated transcriptional sensitivity to METH-mediated DA-induced changes in Egr2 and Egr3 expression in the intact striatum.


Regulation (changes) of Gene_expression (expression) of Egr2 in striatum associated with dopamine
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.39
In this study, we studied the effect of capsaicin-induced stress on the expression of the immediate-early genes (IEGs) NGFI-A, -B, -C, egr-2, -3 and Nurr1 in the rat adrenal gland using in situ hybridization.
Regulation (effect) of Gene_expression (expression) of egr-2 in adrenal gland associated with stress and qutenza
2) Confidence 0.36 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986333 Disease Relevance 0.41 Pain Relevance 0.27

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox