INT90725

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2001
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.09
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tff3) proteinaceous extracellular matrix (Tff3)
Anatomy Link Frequency
hippocampus 4
lateral 2
brain 2
Tff3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 10 100.00 Very High Very High Very High
anesthesia 5 100.00 Very High Very High Very High
alcohol 7 99.66 Very High Very High Very High
Hippocampus 12 99.52 Very High Very High Very High
cocaine 8 99.42 Very High Very High Very High
Sciatic nerve 2 94.64 High High
amygdala 1 78.84 Quite High
addiction 2 49.68 Quite Low
Disease Link Frequency Relevance Heat
Nociception 2 93.16 High High
Drug Dependence 2 48.36 Quite Low
Alcohol Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MK-801 blocked these changes in ITF expressions, but it could also cause the C-fibre stimulations to induce c-Fos and c-Jun in specific areas of the hippocampus.
Regulation (changes) of Gene_expression (expressions) of ITF in hippocampus associated with c fibre and hippocampus
1) Confidence 0.44 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0 Pain Relevance 0.52
Anesthesia can block induction of ITFs by cocaine and alcohol suggesting that ITF expression in a majority of brain regions is more sensitive to secondary effects than to pharmacological effects of these drugs.
Regulation (sensitive) of Gene_expression (expression) of ITF in brain associated with anesthesia, alcohol and cocaine
2) Confidence 0.27 Published 2000 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 11200183 Disease Relevance 0 Pain Relevance 0.39
Here we examine the effects of single, repeated and simultaneous C-fibre inputs on ITF expressions in the rat hippocampus.
Spec (examine) Regulation (effects) of Gene_expression (expressions) of ITF in hippocampus associated with c fibre and hippocampus
3) Confidence 0.26 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0.09 Pain Relevance 0.46
It is not clear whether the suppressive effects of anesthesia on ITF expression in other areas are mediated by activation of lateral habenula, or are independent of this event.
Spec (whether) Regulation (effects) of Gene_expression (expression) of ITF in lateral associated with anesthesia
4) Confidence 0.25 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986339 Disease Relevance 0 Pain Relevance 0.65

General Comments

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