INT90727

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.50
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FosB) DNA binding (FosB)
Anatomy Link Frequency
nucleus accumbens 4
striatum 2
FosB (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 9 100.00 Very High Very High Very High
Nucleus accumbens 7 99.68 Very High Very High Very High
withdrawal 9 99.44 Very High Very High Very High
Morphine 15 99.22 Very High Very High Very High
Dopamine 5 96.64 Very High Very High Very High
Ventral tegmentum 4 90.88 High High
psychological dependence 2 90.00 High High
amygdala 1 89.84 High High
narcan 6 81.36 Quite High
anesthesia 4 79.84 Quite High
Disease Link Frequency Relevance Heat
Weight Loss 2 99.90 Very High Very High Very High
Drug Dependence 5 75.72 Quite High
Syndrome 1 75.00 Quite High
Dyskinesias 1 46.16 Quite Low
Parkinson's Disease 1 5.00 Very Low Very Low Very Low
Recurrence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, agmatine inhibited the increased expression of FosB in the nucleus accumbens caused by chronic morphine.
Negative_regulation (inhibited) of Gene_expression (expression) of FosB in nucleus accumbens associated with nucleus accumbens and morphine
1) Confidence 0.54 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15899480 Disease Relevance 0.15 Pain Relevance 0.88
The suppressive effects of pentobarbital were not specific to c-Fos, such that pentobarbital also suppressed expression of ITFs FosB and Egr1 in the striatum of cocaine-treated rats.
Negative_regulation (suppressed) of Gene_expression (expression) of FosB in striatum associated with cocaine
2) Confidence 0.41 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986339 Disease Relevance 0.06 Pain Relevance 0.68
In intact rats, CREB antisense reduced both basal and cocaine-induced expression of c-Fos, FosB/DeltaFosB, and prodynorphin mRNA.
Negative_regulation (reduced) of Gene_expression (expression) of FosB associated with cocaine
3) Confidence 0.41 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11739600 Disease Relevance 0 Pain Relevance 0.34
The results showed that both MK-801 and DNQX significantly alleviated all symptoms of morphine withdrawal except for weight loss and reduced the expression of stable DeltaFosB isoforms within the nucleus accumbens.
Negative_regulation (reduced) of Gene_expression (expression) of DeltaFosB in nucleus accumbens associated with nucleus accumbens, weight loss, withdrawal and morphine
4) Confidence 0.34 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16303124 Disease Relevance 0.30 Pain Relevance 1.48

General Comments

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