INT90745

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.85
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gpd1) mitochondrion (Gpd1) carbohydrate metabolic process (Gpd1)
cytoplasm (Gpd1)
Anatomy Link Frequency
spinal cord 1
Gpd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.68 Very High Very High Very High
aspirin 1 98.88 Very High Very High Very High
opioid receptor 1 98.00 Very High Very High Very High
Morphine 2 97.86 Very High Very High Very High
Analgesic 2 97.50 Very High Very High Very High
antagonist 1 96.72 Very High Very High Very High
narcan 1 95.84 Very High Very High Very High
bDMF 25 91.04 High High
analgesia 1 75.00 Quite High
Neurobehavioral 5 65.04 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 98.60 Very High Very High Very High
Shock 10 84.60 Quite High
Osteogenic Sarcomas 10 84.16 Quite High
Convulsion 2 80.24 Quite High
Toxicity 6 74.64 Quite High
Poisoning 20 65.92 Quite High
Drug Induced Neurotoxicity 15 59.76 Quite High
Repression 10 53.88 Quite High
Urological Neuroanatomy 40 51.24 Quite High
Apoptosis 36 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment-related increases in Camk1g and Gpd1 mRNA expression were observed for both deltamethrin and permethrin.
Transcription (expression) of Gpd1
1) Confidence 0.67 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.07 Pain Relevance 0.12
The increased expression of Gpd1 and Fkbp51 mRNA indicates an indirect effect on glia due to non-specific activation of the HPA-axis.


Transcription (expression) of Gpd1
2) Confidence 0.67 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.12 Pain Relevance 0.12
Characterization of the time course of mRNA expression for Camk1g, Gpd1, c-fos and Egr1 demonstrates that altered expression of these transcripts also occurs at times earlier than 6 h following acute, oral pyrethroid exposure (Figure 4, Additional file 5).
Transcription (expression) of Gpd1
3) Confidence 0.67 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.14 Pain Relevance 0.13
Dose-dependent changes in the transcription of several genes (Camk1g, Ddc, Gpd3, c-fos and Egr1) were discovered and successfully confirmed.
Transcription (transcription) of Gpd3
4) Confidence 0.67 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.19 Pain Relevance 0.03
Surprisingly, administration of analgesic doses of morphine or the nonsteroidal antiinflammatory drugs aspirin, metamizol (dipyrone), and indomethacin also increased GPDH mRNA levels in rat spinal cord.
Transcription (levels) of GPDH in spinal cord associated with aspirin, inflammation, analgesic, spinal cord and morphine
5) Confidence 0.53 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.25 Pain Relevance 0.71
A main effect of dose was observed for Gpd1 and Fkbp51 mRNA only for deltamethrin (Table 4).
Transcription (observed) of Gpd1
6) Confidence 0.50 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.08 Pain Relevance 0
GAPDH (glyceraldehyde 3-phosphate dehydrogenase) transcript abundance was used as an endogenous control, and Bcl-2 transcript abundance was normalized.


Transcription (abundance) of phosphate dehydrogenase
7) Confidence 0.03 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 0 Pain Relevance 0

General Comments

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