INT90746

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Context Info
Confidence 0.72
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.61
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gpd1) mitochondrion (Gpd1) carbohydrate metabolic process (Gpd1)
cytoplasm (Gpd1)
Anatomy Link Frequency
oligodendrocytes 1
Gpd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
analgesia 1 99.20 Very High Very High Very High
monoamine 15 86.08 High High
Neurotransmitter 30 84.96 Quite High
Spinal cord 2 79.36 Quite High
Analgesic 2 77.56 Quite High
Morphine 2 76.80 Quite High
Dopamine 20 76.00 Quite High
Serotonin 10 74.96 Quite High
aspirin 1 74.72 Quite High
opioid receptor 1 70.56 Quite High
Disease Link Frequency Relevance Heat
Convulsion 2 99.68 Very High Very High Very High
Stress 5 98.00 Very High Very High Very High
Osteogenic Sarcomas 10 91.20 High High
INFLAMMATION 1 75.64 Quite High
Shock 10 61.04 Quite High
Urological Neuroanatomy 40 50.00 Quite Low
Repression 10 44.56 Quite Low
Poisoning 20 26.04 Quite Low
Drug Induced Neurotoxicity 15 5.00 Very Low Very Low Very Low
Neuroblastoma 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that increases in Gpd1 and Fkbp51 expression may be components of a generalized, non-specific stress response brought about by overstimulation of the HPA axis by pyrethroids.
Gene_expression (expression) of Gpd1 associated with stress
1) Confidence 0.72 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.10 Pain Relevance 0.19
The potential impact of increased Gpd1 and Fkbp51 expression on the health and function of affected glia, to date, is unclear.
Gene_expression (expression) of Gpd1
2) Confidence 0.72 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.10 Pain Relevance 0.26
Induction of glycerol phosphate dehydrogenase gene expression during seizure and analgesia.
Gene_expression (expression) of phosphate dehydrogenase associated with convulsion and analgesia
3) Confidence 0.68 Published 2000 Journal J. Neurochem. Section Title Doc Link 10987821 Disease Relevance 0.27 Pain Relevance 0.54
Permethrin-mediated Gpd1 induction was statistically significant while Camk1g induction reflected the trends observed in the dose-response cohorts but did not reach statistical significance.
Gene_expression (induction) of Gpd1
4) Confidence 0.63 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.06 Pain Relevance 0.10
The qRT-PCR expression values for Gpd1 and Fkbp51 closely match those observed in the microarray study.
Gene_expression (expression) of Gpd1
5) Confidence 0.56 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.09 Pain Relevance 0
The proteins encoded by Gpd1 and Fkbp51 are expressed in the brain exclusively in oligodendrocytes [86] and T-cell lymphocytes [87].
Gene_expression (expressed) of Gpd1 in oligodendrocytes
6) Confidence 0.56 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0

General Comments

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