INT90749

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.45
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gpd1) mitochondrion (Gpd1) carbohydrate metabolic process (Gpd1)
cytoplasm (Gpd1)
Anatomy Link Frequency
spinal cord 2
Gpd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.68 Very High Very High Very High
aspirin 1 99.08 Very High Very High Very High
Morphine 2 98.06 Very High Very High Very High
opioid receptor 1 98.00 Very High Very High Very High
Analgesic 2 97.70 Very High Very High Very High
antagonist 1 96.72 Very High Very High Very High
narcan 1 95.84 Very High Very High Very High
bDMF 10 81.80 Quite High
analgesia 1 75.00 Quite High
Neurobehavioral 2 65.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 98.80 Very High Very High Very High
Convulsion 2 80.64 Quite High
Shock 4 75.36 Quite High
Poisoning 8 66.32 Quite High
Repression 4 54.28 Quite High
Urological Neuroanatomy 16 50.00 Quite Low
Osteogenic Sarcomas 4 41.76 Quite Low
Stress 2 20.76 Low Low
Drug Induced Neurotoxicity 6 5.00 Very Low Very Low Very Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased expression of Gpd1 and Fkbp51 mRNA indicates an indirect effect on glia due to non-specific activation of the HPA-axis.


Positive_regulation (increased) of Transcription (expression) of Gpd1
1) Confidence 0.65 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.12 Pain Relevance 0.12
Treatment-related increases in Camk1g and Gpd1 mRNA expression were observed for both deltamethrin and permethrin.
Positive_regulation (increases) of Transcription (expression) of Gpd1
2) Confidence 0.47 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.08 Pain Relevance 0.12
Surprisingly, administration of analgesic doses of morphine or the nonsteroidal antiinflammatory drugs aspirin, metamizol (dipyrone), and indomethacin also increased GPDH mRNA levels in rat spinal cord.
Positive_regulation (increased) of Transcription (levels) of GPDH in spinal cord associated with aspirin, inflammation, analgesic, spinal cord and morphine
3) Confidence 0.47 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.25 Pain Relevance 0.71

General Comments

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