INT90751

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.75
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a1) DNA binding (Nr4a1)
Anatomy Link Frequency
striatum 2
Nr4a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
drug abuse 2 97.16 Very High Very High Very High
anesthesia 9 93.96 High High
Nucleus accumbens 72 93.36 High High
cocaine 210 92.48 High High
withdrawal 4 91.88 High High
Nerve growth factor 2 75.00 Quite High
Enkephalin 3 66.16 Quite High
Neurotransmitter 4 48.28 Quite Low
adenocard 6 39.12 Quite Low
addiction 10 35.28 Quite Low
Disease Link Frequency Relevance Heat
Aids-related Complex 23 100.00 Very High Very High Very High
Drug Dependence 4 97.16 Very High Very High Very High
Schizophrenia 1 67.96 Quite High
Attention Deficit Hyperactivity Disorder 2 40.48 Quite Low
Cocaine Dependence 20 5.00 Very Low Very Low Very Low
Recurrence 16 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, chronic treatment with clozapine reduces NGFI-B expression below basal levels in the rat forebrain, whereas haloperidol still induces high NGFI-B mRNA levels in the dorsolateral striatum.
Negative_regulation (reduces) of Gene_expression (expression) of NGFI-B in striatum
1) Confidence 0.59 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.07 Pain Relevance 0.22
Expression of the genes encoding Per2, Dbp, Arc, Egr1, Krox20 and NGFI-B was suppressed during inhalation of sevoflurane for 2 h and 6 h.
Negative_regulation (suppressed) of Gene_expression (Expression) of NGFI-B associated with aids-related complex
2) Confidence 0.36 Published 2007 Journal Brain Res. Section Abstract Doc Link 17942082 Disease Relevance 0.10 Pain Relevance 0.70
We have previously described altered expression of Arc, CART, Egr1, Fos, NPY, and Nr4a1 in these samples in a directed study of genes with known relevance to drug abuse [12].
Negative_regulation (described) of Gene_expression (expression) of Nr4a1 associated with aids-related complex and drug abuse
3) Confidence 0.25 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.29 Pain Relevance 0.38
We have previously described altered expression of Arc, CART, Egr1, Fos, NPY, and Nr4a1 in these samples in a directed study of genes with known relevance to drug abuse [12].
Negative_regulation (altered) of Gene_expression (expression) of Nr4a1 associated with aids-related complex and drug abuse
4) Confidence 0.25 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.29 Pain Relevance 0.38

General Comments

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