INT90751

Context Info Confidence 0.59 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.75 Pain Relevance 1.69

nucleus (Nr4a1) DNA binding (Nr4a1)

Anatomy Link Frequency striatum 2 Nr4a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat drug abuse 2 97.16 anesthesia 9 93.96 Nucleus accumbens 72 93.36 cocaine 210 92.48 withdrawal 4 91.88 Nerve growth factor 2 75.00 Enkephalin 3 66.16 Neurotransmitter 4 48.28 adenocard 6 39.12 addiction 10 35.28

Disease Link Frequency Relevance Heat Aids-related Complex 23 100.00 Drug Dependence 4 97.16 Schizophrenia 1 67.96 Attention Deficit Hyperactivity Disorder 2 40.48 Cocaine Dependence 20 5.00 Recurrence 16 5.00 Necrosis 4 5.00 Osteogenic Sarcomas 4 5.00 Cancer 4 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, chronic treatment with clozapine reduces NGFI-B expression below basal levels in the rat forebrain, whereas haloperidol still induces high NGFI-B mRNA levels in the dorsolateral striatum.

Negative_regulation (reduces) of Gene_expression (expression) of NGFI-B in striatum

1) Confidence 0.59 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.07 Pain Relevance 0.22

Expression of the genes encoding Per2, Dbp, Arc, Egr1, Krox20 and NGFI-B was suppressed during inhalation of sevoflurane for 2 h and 6 h.

Negative_regulation (suppressed) of Gene_expression (Expression) of NGFI-B associated with aids-related complex

2) Confidence 0.36 Published 2007 Journal Brain Res. Section Abstract Doc Link 17942082 Disease Relevance 0.10 Pain Relevance 0.70

We have previously described altered expression of Arc, CART, Egr1, Fos, NPY, and Nr4a1 in these samples in a directed study of genes with known relevance to drug abuse [12].

Negative_regulation (described) of Gene_expression (expression) of Nr4a1 associated with aids-related complex and drug abuse

3) Confidence 0.25 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.29 Pain Relevance 0.38

We have previously described altered expression of Arc, CART, Egr1, Fos, NPY, and Nr4a1 in these samples in a directed study of genes with known relevance to drug abuse [12].

Negative_regulation (altered) of Gene_expression (expression) of Nr4a1 associated with aids-related complex and drug abuse

4) Confidence 0.25 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.29 Pain Relevance 0.38

General Comments

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