INT90752

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 2.83
Pain Relevance 5.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a1) DNA binding (Nr4a1)
Anatomy Link Frequency
striatum 6
neurons 4
hearts 2
hippocampus 2
Nr4a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 14 99.90 Very High Very High Very High
Enkephalin 40 99.84 Very High Very High Very High
agonist 29 99.56 Very High Very High Very High
Dynorphin 24 99.36 Very High Very High Very High
antagonist 5 99.22 Very High Very High Very High
Opioid 2 99.00 Very High Very High Very High
Hippocampus 30 98.40 Very High Very High Very High
Nucleus accumbens 29 98.32 Very High Very High Very High
Inflammation 2 98.28 Very High Very High Very High
amygdala 33 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Reperfusion Injury 4 99.24 Very High Very High Very High
Apoptosis 24 98.44 Very High Very High Very High
Parkinson's Disease 4 98.36 Very High Very High Very High
INFLAMMATION 2 98.28 Very High Very High Very High
Shock 3 94.56 High High
Death 83 92.04 High High
Aids-related Complex 15 90.24 High High
Schizophrenia 3 84.52 Quite High
Urological Neuroanatomy 3 78.12 Quite High
Disease 12 74.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, haloperidol, but not clozapine, dramatically increases NGFI-B expression in the dorsolateral striatum.
Positive_regulation (increases) of Gene_expression (expression) of NGFI-B in striatum
1) Confidence 0.70 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.07 Pain Relevance 0.22
Using in situ hybridization, we also demonstrate that typical and atypical antipsychotics induced contrasting patterns of expression of NGFI-B after both acute and chronic administration.
Positive_regulation (induced) of Gene_expression (expression) of NGFI-B
2) Confidence 0.70 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.08 Pain Relevance 0.12
Finally, using a double in situ hybridization technique, we show that acute administration of both neuroleptics increases NGFI-B expression in neurotensin-containing neurons in the nucleus accumbens shell, whereas the effects of haloperidol in the dorsolateral striatum are mainly observed in enkephalin-containing neurons.
Positive_regulation (increases) of Gene_expression (expression) of NGFI-B in neurons associated with nucleus accumbens and enkephalin
3) Confidence 0.70 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.06 Pain Relevance 0.25
A combination of selective D(1) and D(2) agonists induced an important increase of striatal NGFI-B expression selectively in DYN-containing neurons.
Positive_regulation (increase) of Gene_expression (expression) of NGFI-B in neurons associated with dynorphin and agonist
4) Confidence 0.69 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 13678671 Disease Relevance 0.07 Pain Relevance 0.60
On the intact side, repeated L-DOPA treatment increased NGFI-B expression in both striatal subpopulations.
Positive_regulation (increased) of Gene_expression (expression) of NGFI-B
5) Confidence 0.69 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 13678671 Disease Relevance 0.07 Pain Relevance 0.62
Denervation and repeated L-DOPA induce a coordinate expression of the transcription factor NGFI-B in striatal projection pathways in hemi-parkinsonian rats.
Positive_regulation (induce) of Gene_expression (expression) of NGFI-B associated with parkinson's disease and enkephalin
6) Confidence 0.69 Published 2003 Journal Neurobiol. Dis. Section Title Doc Link 13678671 Disease Relevance 0.10 Pain Relevance 0.63
We found significant increases in the expression of Nr4a1 (Nur77) in the denervated striatum in comparison to the intact side (SL vs SNL) of hemiparkinsonian rats.
Positive_regulation (increases) of Gene_expression (expression) of Nur77 in striatum
7) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.20
The denervation process induced NT and Nur77 mRNA expression in ENK-positive cells.
Positive_regulation (induced) of Gene_expression (expression) of Nur77 mRNA associated with enkephalin
8) Confidence 0.62 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15896973 Disease Relevance 0.07 Pain Relevance 0.63
Ensure cues also increased ngfi-b expression in limbic regions including the dorsal hippocampus and the basolateral amygdala but not in the central nucleus of the amygdala.
Positive_regulation (increased) of Gene_expression (expression) of ngfi-b in hippocampus associated with hippocampus and amygdala
9) Confidence 0.51 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0 Pain Relevance 0.30
We found significant increases in the expression of Nr4a1 (Nur77) in the denervated striatum in comparison to the intact side (SL vs SNL) of hemiparkinsonian rats.
Positive_regulation (increases) of Gene_expression (expression) of Nr4a1 in striatum
10) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.20
The opioid antagonist, in turn, precipitated withdrawal and increased the expression of a set of genes which are predominantly transcription factors (krox20, CREM, NGFI-B, IkappaB, etc).
Positive_regulation (increased) of Gene_expression (expression) of NGFI-B associated with antagonist, withdrawal and opioid
11) Confidence 0.31 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12670709 Disease Relevance 0.55 Pain Relevance 1.06
In hearts of rats treated with NDP-MSH there was increased expression of the orphan nuclear receptor Nur77.
Positive_regulation (increased) of Gene_expression (expression) of Nur77 in hearts
12) Confidence 0.28 Published 2010 Journal Peptides Section Abstract Doc Link 19799952 Disease Relevance 0.14 Pain Relevance 0.24
In addition, the increased expression of Nur77 and SOCS3 could be part of a broader anti-inflammatory effect.
Positive_regulation (increased) of Gene_expression (expression) of Nur77 associated with inflammation
13) Confidence 0.28 Published 2010 Journal Peptides Section Abstract Doc Link 19799952 Disease Relevance 0.20 Pain Relevance 0.20
Over-expression of Atf3, Nr4a1, GADD45?
Positive_regulation (Over) of Gene_expression (expression) of Nr4a1
14) Confidence 0.09 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 1.40 Pain Relevance 0.27

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