INT90757

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Context Info
Confidence 0.14
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.60
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
amygdala 1
Brp8 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 11 100.00 Very High Very High Very High
amygdala 9 95.48 Very High Very High Very High
Pain 1 90.24 High High
Inflammation 9 82.56 Quite High
Opioid 1 64.48 Quite High
Enkephalin 1 25.00 Low Low
Neuropeptide 1 25.00 Low Low
Eae 7 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 34 100.00 Very High Very High Very High
Targeted Disruption 32 97.76 Very High Very High Very High
Dyskinesias 2 97.20 Very High Very High Very High
Pain 1 90.24 High High
Fatigue 1 87.04 High High
INFLAMMATION 12 82.56 Quite High
Neuroleptic Malignant Syndrome 2 67.36 Quite High
Experimental Diabetes Mellitus 1 50.00 Quite Low
Diabetes Mellitus 28 13.96 Low Low
Frontotemporal Lobar Degeneration 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, PC2 appears to be involved in monobasic processing, leading to the generation of Dyn A-8, Dyn A-17, and Dyn B-13 from prodynorphin under physiological conditions.
Gene_expression (generation) of A-8 associated with dynorphin
1) Confidence 0.14 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.53
In addition, significant improvements were found using the Parkinson's disease sleep scale (PDSS) and the PDQ-8 (QoL).
Gene_expression (using) of PDQ-8 associated with disease
2) Confidence 0.08 Published 2009 Journal Mov. Disord. Section Abstract Doc Link 19425079 Disease Relevance 1.01 Pain Relevance 0.09
The adeno-associated virus 8 (AAV8) vector (1.1×108 genomic copies/µl) expressing marker gene was used to study the effect of corneal drying on gene transfer.
Gene_expression (expressing) of AAV8
3) Confidence 0.02 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2997332 Disease Relevance 0.16 Pain Relevance 0.08
We found that STZ administration in non-transgenic mice resulted in increased phosphorylation of endogenous murine tau at multiple sites, including T181 (AT270), AT8, T212/S214 (AT100), S262/S356 (12E8), S396/S404 (PHF-1) and, to a much lesser degree, pS422 in the RAB fraction of the amygdala homogenate (Figure 5A).
Gene_expression (/) of AT8 in amygdala associated with targeted disruption and amygdala
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775636 Disease Relevance 0.43 Pain Relevance 0.05

General Comments

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