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Context Info
Confidence 0.32
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.70
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Furin) peptidase activity (Furin) extracellular space (Furin)
Golgi apparatus (Furin) plasma membrane (Furin)
Anatomy Link Frequency
brain 1
Furin (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 11 89.52 High High
Mechanotransduction 10 68.00 Quite High
Opioid 1 42.12 Quite Low
nociceptor 16 37.40 Quite Low
Enkephalin 1 25.00 Low Low
Neuropeptide 1 25.00 Low Low
ASIC 2 21.88 Low Low
imagery 29 5.00 Very Low Very Low Very Low
c fibre 10 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 21 99.40 Very High Very High Very High
Dementia 45 98.92 Very High Very High Very High
Neurodegenerative Disease 5 97.40 Very High Very High Very High
Metastasis 90 93.24 High High
Cancer 101 92.72 High High
Carcinoma 16 90.72 High High
Disease 11 86.08 High High
Rheumatoid Arthritis 35 85.56 High High
Malignant Neoplastic Disease 2 83.44 Quite High
Adhesions 2 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The disruption of the PC2 gene does not lead to compensatory up-regulation in the levels of other convertases with similar substrate specificity because we find no significant changes in the levels of PC1, PC5/PC6, or furin in these mice as compared with wild-type mice.
Neg (no) Positive_regulation (changes) of furin
1) Confidence 0.32 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.41
In these conditions, accumulation of a C-terminal peptide (ABri and ADan) cleaved off from the mutated precursor protein by the pro-protein convertase furin [4], leads to amyloid deposition in the walls of blood vessels and parenchyma of the brain.
Positive_regulation (accumulation) of furin in brain associated with alzheimer's dementia
2) Confidence 0.25 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2774945 Disease Relevance 0.69 Pain Relevance 0
We also used 10 times lower concentrations of the furin enzyme (10 U ml?
Positive_regulation (concentrations) of furin
3) Confidence 0.21 Published 2010 Journal EMBO J Section Body Doc Link PMC2810375 Disease Relevance 0.15 Pain Relevance 0.03
In contrast, the expression of mesenchymal markers, including vimentin and fibronectin, whose expression has been shown to positively correlate with the EMT, was strongly increased in SPC-A-1sci cells (Fig. 2B-D).
Positive_regulation (increased) of SPC-A-1sci
4) Confidence 0.13 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.34 Pain Relevance 0
The potentials of cell motility, migration and invasion are greatly increased in SPC-A-1sci cells.
Positive_regulation (increased) of SPC-A-1sci
5) Confidence 0.13 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.53 Pain Relevance 0

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